2.0 2012-05-31 14:29:56 -0600 2015-06-05 20:39:05 -0600 ECMDB20146 M2MDB000994 Ethylene glycol Ethylene glycol (monoethylene glycol (MEG), 1,2-ethanediol, IUPAC name: ethane-1,2-diol) is an alcohol with two -OH groups (a diol), a chemical compound widely used as an automotive antifreeze. In its pure form, it is an odorless, colorless, syrupy, sweet tasting, toxic liquid.Ethylene glycol is also used in the manufacture of some vaccines, but it is not itself present in these injections. It is used as a minor (1 1,2 Ethanediol 1,2-Dihydroxyethane 1,2-Ethandiol 1,2-Ethanediol 2 Hydroxyethanol 2-Hydroxyethanol Aliphatic diol Athylenglykol Athylenglykol(german) Dihydroxyethane Dowtherm SR 1 EDO Ethane-1,2-diol Ethanediol Ethylene alcohol Ethylene dihydrate Ethylene dihydric acid Ethylene gycol Fridex Glycol Glycol alcohol Glycol, ethylene Glycol, monoethylene Glygen HOCH2CH2OH Ilexan e Lutrol 9 M.e.g. Macrogol 400 BPC Monoethylene glycol Norkool PEG RAMP Ramp (van) Tescol Ucar 17 Zerex C2H6O2 62.0678 62.036779436 107-21-1 OCCO InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2 LYCAIKOWRPUZTN-UHFFFAOYSA-N Liquid Cytoplasm Periplasm logp -1.53 ALOGPS logs 1.18 ALOGPS solubility 9.50e+02 g/l ALOGPS melting_point -13 oC average_mass 62.0678 ChemAxon mono_mass 62.036779436 ChemAxon smiles OCCO ChemAxon formula C2H6O2 ChemAxon inchi InChI=1S/C2H6O2/c3-1-2-4/h3-4H,1-2H2 ChemAxon inchikey LYCAIKOWRPUZTN-UHFFFAOYSA-N ChemAxon formal_charge 0 ChemAxon Glyoxylate and dicarboxylate metabolism ec00630 Microbial metabolism in diverse environments ec01120 Chloroalkane and chloroalkene degradation ec00625 Ethylene Glycol Degradation Although wild-type E. coli is unable to utilize ethylene glycol as a carbon source, mutant strains can be isolated that can utilize it. Such strains carry two regulatory mutations: one that elevates the levels of propanediol oxidoreductase, the normal function of which is to metabolize propanediol, and the other that elevates the levels of aldehyde reductases, an enzyme of low specificity which participates in the degradation of fucose. (EcoCyc) PW002093 Metabolic ethylene glycol degradation PWY0-1280 Specdb::CMs 3294 Specdb::CMs 28207 Specdb::CMs 28439 Specdb::CMs 29341 Specdb::CMs 42796 Specdb::CMs 101902 Specdb::CMs 101903 Specdb::CMs 101904 Specdb::CMs 135827 Specdb::CMs 143561 Specdb::EiMs 593 Specdb::NmrOneD 2105 Specdb::NmrOneD 2799 Specdb::NmrOneD 23002 Specdb::NmrOneD 23003 Specdb::NmrOneD 23004 Specdb::NmrOneD 23005 Specdb::NmrOneD 23006 Specdb::NmrOneD 23007 Specdb::NmrOneD 23008 Specdb::NmrOneD 23009 Specdb::NmrOneD 23010 Specdb::NmrOneD 23011 Specdb::NmrOneD 23012 Specdb::NmrOneD 23013 Specdb::NmrOneD 23014 Specdb::NmrOneD 23015 Specdb::NmrOneD 23016 Specdb::NmrOneD 23017 Specdb::NmrOneD 23018 Specdb::NmrOneD 23019 Specdb::NmrOneD 23020 Specdb::NmrOneD 23021 Specdb::MsMs 25049 Specdb::MsMs 25050 Specdb::MsMs 25051 Specdb::MsMs 31607 Specdb::MsMs 31608 Specdb::MsMs 31609 Specdb::MsMs 2751961 Specdb::MsMs 2751962 Specdb::MsMs 2751963 Specdb::MsMs 2930790 Specdb::MsMs 2930791 Specdb::MsMs 2930792 174 C01380 30742 GLYCOL EGL Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. 21097882 Kanehisa, M., Goto, S., Sato, Y., Furumichi, M., Tanabe, M. (2012). "KEGG for integration and interpretation of large-scale molecular data sets." Nucleic Acids Res 40:D109-D114. 22080510 van der Werf, M. J., Overkamp, K. M., Muilwijk, B., Coulier, L., Hankemeier, T. (2007). "Microbial metabolomics: toward a platform with full metabolome coverage." Anal Biochem 370:17-25. 17765195 Winder, C. L., Dunn, W. B., Schuler, S., Broadhurst, D., Jarvis, R., Stephens, G. M., Goodacre, R. (2008). "Global metabolic profiling of Escherichia coli cultures: an evaluation of methods for quenching and extraction of intracellular metabolites." Anal Chem 80:2939-2948. 18331064 Lactaldehyde reductase P0A9S1 FUCO_ECOLI fucO http://ecmdb.ca/proteins/P0A9S1.xml Ethylene glycol + NAD <> Glycolaldehyde + NADH + Hydrogen ion R01781