2.0 2012-07-30 14:55:01 -0600 2015-06-03 17:20:57 -0600 ECMDB21231 M2MDB001639 Hydrogen cyanide HCN is formed in interstellar clouds through one of two major pathways: via a neutral-neutral reaction (CH2 + N <=> HCN + H) and via dissociative recombination (HCNH+ + e- <=> HCN + H). The dissociative recombination pathway is dominant by 30%; however, the HCNH+ must be in its linear form. Dissociative recombination with its structural isomer, H2NC+ produces hydrogen isocyanide (HNC), exclusively.; HCN is produced on an industrial scale and is a highly valuable precursor to many chemical compounds ranging from polymers to pharmaceuticals.; Hydrogen cyanide (with the historical common name of Prussic acid) is an inorganic compound with chemical formula HCN. It is a colorless, extremely poisonous liquid that boils slightly above room temperature at 26 AC Acide cyanhydrique Acido cianidrico Aero Liquid HCN Agent AC Blausaeure Blausaeure (German) Blausaure Blauwzuur Carbon hydride nitride Carbon hydride nitride (CHN) Cn-, cyano Cyaanwaterstof Cyanide Cyanwasserstoff Cyclon Cyclone B Cyjanowodor Evercyn Formic anammonide Formonitrile HCN Hydridonitridocarbon Hydrocyanate Hydrocyanic acid Hydrogen cyanide Hydrogen(nitridocarbonate) Hydrogen(nitridocarbonic acid) Methanenitrile Nitrilomethane Prussate Prussate, unstabilized Prussic Acid Prussic acid, unstabilized Zaclondiscoids Zootate Zootic acid [CHN] CHN 27.0253 27.010899037 formonitrile hydrogen cyanide 74-90-8 C#N InChI=1S/CHN/c1-2/h1H LELOWRISYMNNSU-UHFFFAOYSA-N Liquid Cytosol Extra-organism Periplasm logp -0.65 ALOGPS logs -0.92 ALOGPS solubility 3.26e+00 g/l ALOGPS melting_point -13.4 oC logp -0.35 ChemAxon pka_strongest_acidic 9.5 ChemAxon iupac formonitrile ChemAxon average_mass 27.0253 ChemAxon mono_mass 27.010899037 ChemAxon smiles C#N ChemAxon formula CHN ChemAxon inchi InChI=1S/CHN/c1-2/h1H ChemAxon inchikey LELOWRISYMNNSU-UHFFFAOYSA-N ChemAxon polar_surface_area 23.79 ChemAxon refractivity 7.01 ChemAxon polarizability 2.31 ChemAxon rotatable_bond_count 0 ChemAxon acceptor_count 1 ChemAxon donor_count 0 ChemAxon physiological_charge 0 ChemAxon formal_charge 0 ChemAxon Thiosulfate Disproportionation III Thiosulfate sulfurtransferase is more often referred to by the name rhodanese, from the German word for thiocyanate, "rhodanid". The enzyme catalyzes the transfer of a sulfur atom from suitable sulfur donors to nucleophilic sulfur acceptors. The original description of rhodanese, purified from bovine mitochondria, used thiosulfate and cyanide for this purpose. Rhodanese is a widespread enzyme, and has been detected in many major phyla, both prokaryotic and eukaryotic. Despite its ubiquity, the physiological role of rhodanese has not yet been established unambiguously. It has been suggested that rhodanese is involved in detoxification of cyanide in both mammals and bacteria. It has also been proposed that rhodanese, using the dithiol dihydrolipoate as the sulfur acceptor, may act as a sulfur insertase involved in the formation of prosthetic groups in iron-sulfur proteins, such as ferredoxin. (EcoCyc) PW002060 Metabolic thiosulfate disproportionation III (rhodanese) PWY-5350 Specdb::CMs 34474 Specdb::CMs 172526 Specdb::EiMs 342 Specdb::NmrOneD 2604 Specdb::NmrOneD 56882 Specdb::NmrOneD 56883 Specdb::NmrOneD 56884 Specdb::NmrOneD 56885 Specdb::NmrOneD 56886 Specdb::NmrOneD 56887 Specdb::NmrOneD 56888 Specdb::NmrOneD 56889 Specdb::NmrOneD 56890 Specdb::NmrOneD 56891 Specdb::MsMs 9368 Specdb::MsMs 9369 Specdb::MsMs 9370 Specdb::MsMs 16040 Specdb::MsMs 16041 Specdb::MsMs 16042 768 748 C01326 18407 HCN CYN Hydrogen_cyanide Keseler, I. M., Collado-Vides, J., Santos-Zavaleta, A., Peralta-Gil, M., Gama-Castro, S., Muniz-Rascado, L., Bonavides-Martinez, C., Paley, S., Krummenacker, M., Altman, T., Kaipa, P., Spaulding, A., Pacheco, J., Latendresse, M., Fulcher, C., Sarker, M., Shearer, A. G., Mackie, A., Paulsen, I., Gunsalus, R. P., Karp, P. D. (2011). "EcoCyc: a comprehensive database of Escherichia coli biology." Nucleic Acids Res 39:D583-D590. 21097882 Thiosulfate sulfurtransferase glpE P0A6V5 GLPE_ECOLI glpE http://ecmdb.ca/proteins/P0A6V5.xml 3-mercaptopyruvate sulfurtransferase P31142 THTM_ECOLI sseA http://ecmdb.ca/proteins/P31142.xml Thiosulfate sulfurtransferase YnjE P78067 YNJE_ECOLI ynjE http://ecmdb.ca/proteins/P78067.xml Thiosulfate sulfurtransferase PspE P23857 PSPE_ECOLI pspE http://ecmdb.ca/proteins/P23857.xml Outer membrane protein N P77747 OMPN_ECOLI ompN http://ecmdb.ca/proteins/P77747.xml Outer membrane pore protein E P02932 PHOE_ECOLI phoE http://ecmdb.ca/proteins/P02932.xml Outer membrane protein F P02931 OMPF_ECOLI ompF http://ecmdb.ca/proteins/P02931.xml Outer membrane protein C P06996 OMPC_ECOLI ompC http://ecmdb.ca/proteins/P06996.xml Hydrogen cyanide + Thiosulfate > Hydrogen ion + Sulfite + Thiocyanate Hydrogen cyanide + 3-Mercaptopyruvic acid + Cyanide <> Hydrogen ion + Pyruvic acid + Thiocyanate R03106 MERCAPYSTRANS-RXN Hydrogen cyanide + 3-Mercaptopyruvic acid <> Thiocyanate + Pyruvic acid R03106 MERCAPYSTRANS-RXN Hydrogen cyanide + 3-Mercaptopyruvic acid Hydrogen ion + Pyruvic acid + Thiocyanate MERCAPYSTRANS-RXN <i>S</i>-sulfanyl-[acceptor] + Hydrogen cyanide an unsulfurated sulfur acceptor + Thiocyanate + Hydrogen ion RXN0-6359 Thiosulfate + Hydrogen cyanide > Sulfite + Thiocyanate 3-Mercaptopyruvic acid + Hydrogen cyanide > Pyruvic acid + Thiocyanate Hydrogen cyanide + Thiosulfate > Thiocyanate + Sulfite +2 Hydrogen ion PW_R006013