2.02012-07-30 14:55:25 -06002015-06-03 17:21:13 -0600ECMDB21355M2MDB001752SeleniteThe selenite anion is a selenium oxoanion with the chemical formula SeO32−. A selenite (compound) is a compound that contains this ion. In slightly acid conditions, the hydrogenselenite ion, HSeO3−, is formed; in more acidic conditions selenous acid, H2SeO3, exists. Most selenite salts can be formed by heating the relevant metal oxide with selenium dioxide, e.g.:Na2O + SeO2 → Na2SeO3. Selenite is an inorganic form of selenium which may also be useful in cancer chemotherapy.(Wikipedia)SelenitSeleniteSelenite (SeO32-)Selenite ion (SeO32-)Selenite ion(2-)Selenite(2-)Trioxidoselenate(2)Trioxidoselenic acid(2)Trioxoselenate(2)Trioxoselenate(4)Trioxoselenic acid(2)Trioxoselenic acid(4)[SeO3]2O3Se126.96127.901265694selenous acidselenious acid14124-67-5[O-][Se]([O-])=OInChI=1S/H2O3Se/c1-4(2)3/h(H2,1,2,3)/p-2MCAHWIHFGHIESP-UHFFFAOYSA-LSolidCytosolExtra-organismPeriplasmlogp-1.3pka_strongest_acidic1.2iupacselenous acidaverage_mass126.96mono_mass127.901265694smiles[O-][Se]([O-])=OformulaO3SeinchiInChI=1S/H2O3Se/c1-4(2)3/h(H2,1,2,3)/p-2inchikeyMCAHWIHFGHIESP-UHFFFAOYSA-Lpolar_surface_area57.53refractivity19.69polarizability5.84rotatable_bond_count0acceptor_count4donor_count2physiological_charge-2formal_charge0Selenoamino acid metabolismec00450Selenium metabolismThe selenium metabolism begins with the introduction of selenate and selenite to the cytosol through a sulphate permease system. Once in the cell, selenate can be reduced to selenite through nitrate reductases A and Z. Selenite then interacts with glutathione and 2 hydrogen ions resulting in the release of 2 water molecules, a hydroxide molecule, a glutathione disulfide and a selenodiglutathione. The latter compound then reacts with NADPH+H resulting in the release of a NADP, a glutathione and a glutathioselenol.
Glutathiolselenol can then be oxidize resulting in a a glutathiolselenol ion which can then interact with a water molecule resulting in a release of glutathion and selenium
Glutathiolselenol can also react with NADPH and hydrogen ion resulting in a release of glutathione, NADP, a hydroxide molecule and a hydrogen selenide. This compound can react in a reversible reaction by being oxidized resulting in a hydrogen selenide ion . This compound can then be phosphorylated by interacting with an ATP and releasing a AMP, a phosphate and a selenophosphate.PW001894Metabolicinner membrane transportlist of inner membrane transport complexes, transporting compounds from the periplasmic space to the cytosol
This pathway should be updated regularly with the new inner membrae transports addedPW000786MetabolicSpecdb::CMs169794Specdb::MsMs63609Specdb::MsMs63610Specdb::MsMs63611Specdb::MsMs120576Specdb::MsMs120577Specdb::MsMs120578Specdb::MsMs2276202Specdb::MsMs2276203Specdb::MsMs2276204Specdb::MsMs3092293Specdb::MsMs3092294Specdb::MsMs3092295HMDB1111910901059C0568418212SELENITESelenite_(ion)Respiratory nitrate reductase 1 alpha chainP09152NARG_ECOLInarGhttp://ecmdb.ca/proteins/P09152.xmlThioredoxin reductaseP0A9P4TRXB_ECOLItrxBhttp://ecmdb.ca/proteins/P0A9P4.xmlProbable anaerobic dimethyl sulfoxide reductase chain ynfGP0AAJ1YNFG_ECOLIynfGhttp://ecmdb.ca/proteins/P0AAJ1.xmlRespiratory nitrate reductase 2 gamma chainP0AF32NARV_ECOLInarVhttp://ecmdb.ca/proteins/P0AF32.xmlRespiratory nitrate reductase 1 beta chainP11349NARH_ECOLInarHhttp://ecmdb.ca/proteins/P11349.xmlRespiratory nitrate reductase 1 gamma chainP11350NARI_ECOLInarIhttp://ecmdb.ca/proteins/P11350.xmlSulfate/thiosulfate import ATP-binding protein cysAP16676CYSA_ECOLIcysAhttp://ecmdb.ca/proteins/P16676.xmlProbable nitrate reductase molybdenum cofactor assembly chaperone NarWP19317NARW_ECOLInarWhttp://ecmdb.ca/proteins/P19317.xmlRespiratory nitrate reductase 2 beta chainP19318NARY_ECOLInarYhttp://ecmdb.ca/proteins/P19318.xmlRespiratory nitrate reductase 2 alpha chainP19319NARZ_ECOLInarZhttp://ecmdb.ca/proteins/P19319.xmlPeriplasmic nitrate reductaseP33937NAPA_ECOLInapAhttp://ecmdb.ca/proteins/P33937.xmlPutative dimethyl sulfoxide reductase chain ynfEP77374YNFE_ECOLIynfEhttp://ecmdb.ca/proteins/P77374.xmlProbable dimethyl sulfoxide reductase chain ynfFP77783YNFF_ECOLIynfFhttp://ecmdb.ca/proteins/P77783.xmlSulfate transport system permease protein cysWP0AEB0CYSW_ECOLIcysWhttp://ecmdb.ca/proteins/P0AEB0.xmlSulfate transport system permease protein cysTP16701CYST_ECOLIcysUhttp://ecmdb.ca/proteins/P16701.xmlThiosulfate-binding proteinP16700CYSP_ECOLIcysPhttp://ecmdb.ca/proteins/P16700.xmlDiheme cytochrome c napBP0ABL3NAPB_ECOLInapBhttp://ecmdb.ca/proteins/P0ABL3.xmlAnaerobic dimethyl sulfoxide reductase chain ynfHP76173YNFH_ECOLIynfHhttp://ecmdb.ca/proteins/P76173.xmlNitrate reductase molybdenum cofactor assembly chaperone NarJP0AF26NARJ_ECOLInarJhttp://ecmdb.ca/proteins/P0AF26.xmlSulfate/thiosulfate import ATP-binding protein cysAP16676CYSA_ECOLIcysAhttp://ecmdb.ca/proteins/P16676.xmlSulfate transport system permease protein cysWP0AEB0CYSW_ECOLIcysWhttp://ecmdb.ca/proteins/P0AEB0.xmlSulfate transport system permease protein cysTP16701CYST_ECOLIcysUhttp://ecmdb.ca/proteins/P16701.xmlOuter membrane protein NP77747OMPN_ECOLIompNhttp://ecmdb.ca/proteins/P77747.xmlThiosulfate-binding proteinP16700CYSP_ECOLIcysPhttp://ecmdb.ca/proteins/P16700.xmlOuter membrane pore protein EP02932PHOE_ECOLIphoEhttp://ecmdb.ca/proteins/P02932.xmlOuter membrane protein FP02931OMPF_ECOLIompFhttp://ecmdb.ca/proteins/P02931.xmlOuter membrane protein CP06996OMPC_ECOLIompChttp://ecmdb.ca/proteins/P06996.xmlMenaquinol 8 + Selenocystathionine > Water + Menaquinone 8 + SeleniteHydrogen selenide + 3 NADP + 3 Water <> Selenite +3 NADPH +5 Hydrogen ionR03596Selenite + Glutathione + Hydrogen ion > Selenodiglutathione + Glutathione disulfide + WaterRXN-12864Selenite + Water + an oxidized electron acceptor < selenate + a reduced electron acceptorRXN0-2101Selenite + Water + Adenosine triphosphate > Selenite + ADP + Phosphate + Hydrogen ionTRANS-RXN0-479Selenite + Water + Adenosine triphosphate > Selenite + ADP + Phosphate + Hydrogen ionTRANS-RXN0-479Selenite + Water + Acceptor <> Selenate + Reduced acceptorR07229 Selenate + 2 Hydrogen ion + 2 Electron > Selenite + WaterPW_R005187Hydrogen selenide + 3 NADP + 3 Water <> Selenite +3 NADPH