ECMDB: Protein GrpE (P09372)

Identification

Name:

Protein GrpE

Synonyms:

Not Available

Gene Name:

grpE

Enzyme Class:

Not Available

Biological Properties

General Function:

response to heat

Specific Function:

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.

Cellular Location:

Not Available

SMPDB Pathways:

Not Available

KEGG Pathways:

Not Available

Metabolites:

ECMDB ID	Name	View

GO Classification:

Function
adenyl-nucleotide exchange factor activity
cytoplasm
protein folding
protein unfolding
response to heat

Gene Properties

Blattner:

Not Available

Gene Orientation

Not Available

Centisome Percentage:

Not Available

Left Sequence End

Not Available

Right Sequence End

Not Available

Gene Sequence:

>594
atgagtagtaaagaacagaaaacgcctgaggggcaagccccggaagaaattatcatggat
cagcacgaagagattgaggcagttgagccagaagcttctgctgagcaggtggatccgcgc
gatgaaaaagttgcgaatctcgaagctcagctggctgaagcccagacccgtgaacgtgac
ggcattttgcgtgtaaaagccgaaatggaaaacctgcgtcgtcgtactgaactggatatt
gaaaaagcccacaaattcgcgctggagaaattcatcaacgaattgctgccggtgattgat
agcctggatcgtgcgctggaagtggctgataaagctaacccggatatgtctgcgatggtt
gaaggcattgagctgacgctgaagtcgatgctggatgttgtgcgtaagtttggcgttgaa
gtgatcgccgaaactaacgtcccactggacccgaatgtgcatcaggccatcgcaatggtg
gaatctgatgacgttgcgccaggtaacgtactgggcattatgcagaagggttatacgctg
aatggtcgtacgattcgtgcggcgatggttactgtagcgaaagcaaaagcttaa

Protein Properties

Pfam Domain Function:

Not Available

Protein Residues:

197

Protein Molecular Weight:

21797

Protein Theoretical pI:

Not Available

PDB File:

1DKG

Signaling Regions:

Not Available

Transmembrane Regions:

Not Available

Protein Sequence:

>Protein GrpE
MSSKEQKTPEGQAPEEIIMDQHEEIEAVEPEASAEQVDPRDEKVANLEAQLAEAQTRERD
GILRVKAEMENLRRRTELDIEKAHKFALEKFINELLPVIDSLDRALEVADKANPDMSAMV
EGIELTLKSMLDVVRKFGVEVIAETNVPLDPNVHQAIAMVESDDVAPGNVLGIMQKGYTL
NGRTIRAAMVTVAKAKA

References

External Links:

Resource	Link
Uniprot ID:	P09372
Uniprot Name:	GRPE_ECOLI
PDB ID:	1DKG
CCDB:	GRPE_ECOLI

General Reference:

Not Available