Identification
Name:Endonuclease 4
Synonyms:Not Available
Gene Name:nfo
Enzyme Class:
Biological Properties
General Function:nucleic acid phosphodiester bond hydrolysis
Specific Function:Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:
Metabolites:
ECMDB IDNameView
GO Classification:
Function
base-excision repair
deoxyribonuclease IV (phage-T4-induced) activity
DNA binding
DNA-(apurinic or apyrimidinic site) lyase activity
endonuclease activity
non-recombinational repair
nucleic acid phosphodiester bond hydrolysis
phosphoric diester hydrolase activity
zinc ion binding
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>858
atgaaatacattggagcgcacgttagtgctgctggcggtctggcaaatgccgcaattcgc
gccgccgaaatcgacgcaaccgcgtttgccttgttcaccaaaaaccaacgtcagtggcgt
gccgcaccgctcacgacgcaaaccatcgatgaattcaaagccgcctgtgaaaaatatcac
tacacatcggcgcaaattcttccccacgacagttatctgattaacctcggacatccggtc
actgaagctctggaaaaatcgcgcgatgcctttatagatgaaatgcagcgttgcgaacag
ctggggctttctttgctcaacttccaccctggcagccatctgatgcagatttcagaagag
gattgccttgcgcgtattgccgaatccatcaacattgcgctggataaaactcaaggtgtg
acagcggtgatagaaaacaccgccggtcagggcagtaacttagggtttaaattcgaacat
ctcgcggcgattatcgacggcgtggaagataaatcccgcgtcggcgtctgcattgatacc
tgccatgctttcgctgccgggtatgatttgcgtactccagccgaatgcgagaaaacattc
gcggattttgcccgtactgtcggctttaagtatctgcgcgggatgcaccttaacgatgcg
aaaagcacctttggcagccgcgttgaccgccatcatagcctcggtgaaggcaatatcggt
catgatgcgttccgctggatcatgcaggacgaccgtttcgacggcattccgctgatcctc
gaaaccatcaacccggatatctgggcagaagagatcgcctggctgaaagcgcaacaaact
gaaaaagcggtagcctga
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:285
Protein Molecular Weight:31479
Protein Theoretical pI:Not Available
PDB File:1QTW
Signaling Regions:Not Available
Transmembrane Regions:Not Available
Protein Sequence:
>Endonuclease 4
MKYIGAHVSAAGGLANAAIRAAEIDATAFALFTKNQRQWRAAPLTTQTIDEFKAACEKYH
YTSAQILPHDSYLINLGHPVTEALEKSRDAFIDEMQRCEQLGLSLLNFHPGSHLMQISEE
DCLARIAESINIALDKTQGVTAVIENTAGQGSNLGFKFEHLAAIIDGVEDKSRVGVCIDT
CHAFAAGYDLRTPAECEKTFADFARTVGFKYLRGMHLNDAKSTFGSRVDRHHSLGEGNIG
HDAFRWIMQDDRFDGIPLILETINPDIWAEEIAWLKAQQTEKAVA
References
External Links:
ResourceLink
Uniprot ID:P0A6C1
Uniprot Name:END4_ECOLI
PDB ID:1QTW
CCDB:END4_ECOLI
General Reference:Not Available