Identification |
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Name: | Elongation factor P |
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Synonyms: | Not Available |
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Gene Name: | efp |
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Enzyme Class: | Not Available |
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Biological Properties |
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General Function: | translational elongation |
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Specific Function: | Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Beta-lysylation at Lys-34 is required for alleviation. The Pro codons and their context do not affect activity; only consecutive Pro residues (not another amino acid) are affected by EF-P. Has stimulatory effects on peptide bond formation between ribosome-bound initiator tRNA(fMet) and puromycin, and N-acetyl-Phe tRNA(Phe)-primed poly(U)-directed poly(Phe) synthesis. |
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Cellular Location: | Not Available |
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SMPDB Pathways: | Not Available |
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KEGG Pathways: | Not Available |
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Metabolites: | |
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GO Classification: | Function |
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cytoplasm | cytosol | peptide biosynthetic process | ribosome binding | translation elongation factor activity | translational elongation |
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Gene Properties |
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Blattner: | Not Available |
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Gene Orientation | Not Available |
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Centisome Percentage: | Not Available |
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Left Sequence End | Not Available |
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Right Sequence End | Not Available |
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Gene Sequence: | >567
atggcaacgtactatagcaacgattttcgtgctggtcttaaaatcatgttagacggcgaa
ccttacgcggttgaagcgagtgaattcgtaaaaccgggtaaaggccaggcatttgctcgc
gttaaactgcgtcgtctgctgaccggtactcgcgtagaaaaaaccttcaaatctactgat
tccgctgaaggcgctgatgttgtcgatatgaacctgacttacctgtacaacgacggtgag
ttctggcacttcatgaacaacgaaactttcgagcagctgtctgctgatgcaaaagcaatt
ggtgacaacgctaaatggctgctggatcaggcagagtgtatcgtaactctgtggaatggt
cagccgatctccgttactccgccgaacttcgttgaactggaaatcgttgataccgatccg
ggcctgaaaggtgataccgcaggtactggtggcaaaccggctaccctgtctactggcgct
gtggttaaagttccgctgtttgtacaaatcggcgaagtcatcaaagtggatacccgctct
ggtgaatacgtctctcgcgtgaagtaa |
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Protein Properties |
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Pfam Domain Function: | Not Available |
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Protein Residues: | 188 |
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Protein Molecular Weight: | 20591 |
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Protein Theoretical pI: | Not Available |
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PDB File: | 3A5Z |
Signaling Regions: | Not Available |
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Transmembrane Regions: | Not Available |
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Protein Sequence: | >Elongation factor P
MATYYSNDFRAGLKIMLDGEPYAVEASEFVKPGKGQAFARVKLRRLLTGTRVEKTFKSTD
SAEGADVVDMNLTYLYNDGEFWHFMNNETFEQLSADAKAIGDNAKWLLDQAECIVTLWNG
QPISVTPPNFVELEIVDTDPGLKGDTAGTGGKPATLSTGAVVKVPLFVQIGEVIKVDTRS
GEYVSRVK |
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References |
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External Links: | |
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General Reference: | Not Available |
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