Identification
Name:Elongation factor P
Synonyms:Not Available
Gene Name:efp
Enzyme Class:Not Available
Biological Properties
General Function:translational elongation
Specific Function:Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Beta-lysylation at Lys-34 is required for alleviation. The Pro codons and their context do not affect activity; only consecutive Pro residues (not another amino acid) are affected by EF-P. Has stimulatory effects on peptide bond formation between ribosome-bound initiator tRNA(fMet) and puromycin, and N-acetyl-Phe tRNA(Phe)-primed poly(U)-directed poly(Phe) synthesis.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
cytoplasm
cytosol
peptide biosynthetic process
ribosome binding
translation elongation factor activity
translational elongation
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>567
atggcaacgtactatagcaacgattttcgtgctggtcttaaaatcatgttagacggcgaa
ccttacgcggttgaagcgagtgaattcgtaaaaccgggtaaaggccaggcatttgctcgc
gttaaactgcgtcgtctgctgaccggtactcgcgtagaaaaaaccttcaaatctactgat
tccgctgaaggcgctgatgttgtcgatatgaacctgacttacctgtacaacgacggtgag
ttctggcacttcatgaacaacgaaactttcgagcagctgtctgctgatgcaaaagcaatt
ggtgacaacgctaaatggctgctggatcaggcagagtgtatcgtaactctgtggaatggt
cagccgatctccgttactccgccgaacttcgttgaactggaaatcgttgataccgatccg
ggcctgaaaggtgataccgcaggtactggtggcaaaccggctaccctgtctactggcgct
gtggttaaagttccgctgtttgtacaaatcggcgaagtcatcaaagtggatacccgctct
ggtgaatacgtctctcgcgtgaagtaa
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:188
Protein Molecular Weight:20591
Protein Theoretical pI:Not Available
PDB File:3A5Z
Signaling Regions:Not Available
Transmembrane Regions:Not Available
Protein Sequence:
>Elongation factor P
MATYYSNDFRAGLKIMLDGEPYAVEASEFVKPGKGQAFARVKLRRLLTGTRVEKTFKSTD
SAEGADVVDMNLTYLYNDGEFWHFMNNETFEQLSADAKAIGDNAKWLLDQAECIVTLWNG
QPISVTPPNFVELEIVDTDPGLKGDTAGTGGKPATLSTGAVVKVPLFVQIGEVIKVDTRS
GEYVSRVK
References
External Links:
ResourceLink
Uniprot ID:P0A6N4
Uniprot Name:EFP_ECOLI
PDB ID:3A5Z
CCDB:EFP_ECOLI
General Reference:Not Available