3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase (P0A6Q3)

• Beta-hydroxydecanoyl thioester dehydrase

• 4.2.1.60
• 4.2.1.59

• Fatty acid biosynthesis PW000900
• Fatty acid metabolism PW000796
• fatty acid elongation -- saturated PW000798

• Fatty acid biosynthesis ec00061
• Fatty acid metabolism ec00071

>519 bp
ATGACCATTTTGCCACGCCATAAAGATGTCGCGAAAAGTCGCCTGAAGATGAGTAATCCG
TGGCATCTACTTGCTGTCGGATTCGGAAGTGGATTAAGCCCGATCGTTCCTGGGACGATG
GGCTCGCTGGCAGCGATTCCGTTCTGGTATCTGATGACCTTTTTGCCCTGGCAGCTCTAC
TCGCTGGTGGTGATGCTGGGGATCTGTATCGGCGTCTATCTTTGTCATCAAACGGCGAAA
GACATGGGTGTGCACGATCATGGCAGCATTGTCTGGGACGAATTTATTGGTATGTGGATC
ACGCTCATGGCGCTGCCGACCAATGACTGGCAGTGGGTTGCCGCCGGGTTTGTGATTTTC
CGTATTCTGGATATGTGGAAGCCGTGGCCGATCCGCTGGTTTGATCGCAATGTGCATGGC
GGCATGGGGATCATGATCGACGATATTGTCGCCGGGGTGATTTCCGCAGGCATCCTGTAT
TTTATCGGTCATCACTGGCCGCTGGGTATTCTGTCGTAG

• FabA (PF07977 )

• None

• None

>3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase
MVDKRESYTKEDLLASGRGELFGAKGPQLPAPNMLMMDRVVKMTETGGNFDKGYVEAELD
INPDLWFFGCHFIGDPVMPGCLGLDAMWQLVGFYLGWLGGEGKGRALGVGEVKFTGQVLP
TAKKVTYRIHFKRIVNRRLIMGLADGEVLVDGRLIYTASDLKVGLFQDTSAF

• Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
• Cronan, J. E. Jr, Li, W. B., Coleman, R., Narasimhan, M., de Mendoza, D., Schwab, J. M. (1988). "Derived amino acid sequence and identification of active site residues of Escherichia coli beta-hydroxydecanoyl thioester dehydrase." J Biol Chem 263:4641-4646. Pubmed: 2832401
• Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
• Henry, M. F., Cronan, J. E. Jr (1992). "A new mechanism of transcriptional regulation: release of an activator triggered by small molecule binding." Cell 70:671-679. Pubmed: 1505031
• Leesong, M., Henderson, B. S., Gillig, J. R., Schwab, J. M., Smith, J. L. (1996). "Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site." Structure 4:253-264. Pubmed: 8805534
• Oshima, T., Aiba, H., Baba, T., Fujita, K., Hayashi, K., Honjo, A., Ikemoto, K., Inada, T., Itoh, T., Kajihara, M., Kanai, K., Kashimoto, K., Kimura, S., Kitagawa, M., Makino, K., Masuda, S., Miki, T., Mizobuchi, K., Mori, H., Motomura, K., Nakamura, Y., Nashimoto, H., Nishio, Y., Saito, N., Horiuchi, T., et, a. l. .. (1996). "A 718-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 12.7-28.0 min region on the linkage map." DNA Res 3:137-155. Pubmed: 8905232
• Rock, C. O., Tsay, J. T., Heath, R., Jackowski, S. (1996). "Increased unsaturated fatty acid production associated with a suppressor of the fabA6(Ts) mutation in Escherichia coli." J Bacteriol 178:5382-5387. Pubmed: 8808925