Identification
Name:Transcription elongation factor GreA
Synonyms:Not Available
Gene Name:greA
Enzyme Class:Not Available
Biological Properties
General Function:regulation of DNA-templated transcription, elongation
Specific Function:Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
bacterial-type RNA polymerase holo enzyme binding
cytoplasm
DNA binding
DNA-templated transcription, elongation
regulation of DNA-templated transcription, elongation
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>477
atgcaagctattccgatgaccttacgcggcgctgaaaaattacgcgaagagctggatttt
ctgaaatctgtgcgccgtcctgaaatcattgctgctatcgcggaagcgcgtgagcatggc
gacctgaaagaaaacgccgaataccacgcagctcgtgaacagcagggtttctgcgaaggc
cgtattaaagacatcgaagccaagctgtcgaacgcgcaggtgattgatgtcaccaaaatg
cccaacaatgggcgcgttatttttggtgctaccgtaacggtgctgaatctggattctgac
gaagaacagacttatcgcatcgttggcgatgacgaagctgactttaaacaaaacctgatt
tctgtaaactcgcctattgctcgtggcctgatcggcaaagaagaagatgatgttgtggtc
atcaaaacgccgggcggcgaagtagaatttgaagtaattaaggtggaatacctgtaa
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:158
Protein Molecular Weight:17640
Protein Theoretical pI:Not Available
PDB File:1GRJ
Signaling Regions:Not Available
Transmembrane Regions:Not Available
Protein Sequence:
>Transcription elongation factor GreA
MQAIPMTLRGAEKLREELDFLKSVRRPEIIAAIAEAREHGDLKENAEYHAAREQQGFCEG
RIKDIEAKLSNAQVIDVTKMPNNGRVIFGATVTVLNLDSDEEQTYRIVGDDEADFKQNLI
SVNSPIARGLIGKEEDDVVVIKTPGGEVEFEVIKVEYL
References
External Links:
ResourceLink
Uniprot ID:P0A6W5
Uniprot Name:GREA_ECOLI
PDB ID:1GRJ
CCDB:GREA_ECOLI
General Reference:Not Available