ECMDB: ATP-dependent protease subunit HslV (P0A7B8)

Identification

Name:

ATP-dependent protease subunit HslV

Synonyms:

Not Available

Gene Name:

hslV

Enzyme Class:

3.4.25.2

Biological Properties

General Function:

response to heat

Specific Function:

Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. The complex has been shown to be involved in the specific degradation of heat shock induced transcription factors such as RpoH and SulA. In addition, small hydrophobic peptides are also hydrolyzed by HslV. HslV has weak protease activity even in the absence of HslU, but this activity is induced more than 100-fold in the presence of HslU. HslU recognizes protein substrates and unfolds these before guiding them to HslV for hydrolysis. HslV is not believed to degrade folded proteins.

Cellular Location:

Not Available

SMPDB Pathways:

Not Available

KEGG Pathways:

Not Available

Metabolites:

ECMDB ID	Name	View

GO Classification:

Function
cytosol
HslUV protease complex
identical protein binding
metal ion binding
proteasome core complex
proteolysis involved in cellular protein catabolic process
response to heat
threonine-type endopeptidase activity

Gene Properties

Blattner:

Not Available

Gene Orientation

Not Available

Centisome Percentage:

Not Available

Left Sequence End

Not Available

Right Sequence End

Not Available

Gene Sequence:

>531
gtgacaactatagtaagcgtacgccgtaacggccatgtggtcatcgctggtgatggtcag
gccacgttgggcaataccgtaatgaaaggcaacgtgaaaaaggtccgccgtctgtacaac
gacaaagtcatcgcgggctttgcgggcggtactgcggatgcttttacgctgttcgaactg
tttgaacgtaaactggaaatgcatcagggccatctggtcaaagccgccgttgagctggca
aaagactggcgtaccgatcgcatgctgcgcaaacttgaagcactgctggcagtcgcggat
gaaactgcatcgcttatcatcaccggtaacggtgacgtggtgcagccagaaaacgatctt
attgctatcggctccggcggcccttacgcccaggctgcggcgcgcgcgctgttagaaaac
actgaacttagcgcccgtgaaattgctgaaaaggcgttggatattgcaggcgacatttgc
atctataccaaccatttccacaccatcgaagaattaagctacaaagcgtaa

Protein Properties

Pfam Domain Function:

Not Available

Protein Residues:

176

Protein Molecular Weight:

19092

Protein Theoretical pI:

Not Available

PDB File:

1E94

Signaling Regions:

Not Available

Transmembrane Regions:

Not Available

Protein Sequence:

>ATP-dependent protease subunit HslV
MTTIVSVRRNGHVVIAGDGQATLGNTVMKGNVKKVRRLYNDKVIAGFAGGTADAFTLFEL
FERKLEMHQGHLVKAAVELAKDWRTDRMLRKLEALLAVADETASLIITGNGDVVQPENDL
IAIGSGGPYAQAAARALLENTELSAREIAEKALDIAGDICIYTNHFHTIEELSYKA

References

External Links:

Resource	Link
Uniprot ID:	P0A7B8
Uniprot Name:	HSLV_ECOLI
PDB ID:	1E94
CCDB:	HSLV_ECOLI

General Reference:

Not Available