Identification
Name:Trigger factor
Synonyms:
  • TF
Gene Name:tig
Enzyme Class:Not Available
Biological Properties
General Function:Posttranslational modification, protein turnover, chaperones
Specific Function:Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Binds to nascent polypeptide chains via ribosomal protein L23 (PubMed:12226666)
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Process
cellular protein metabolic process
establishment of localization
macromolecule metabolic process
metabolic process
protein folding
protein metabolic process
protein transport
transport
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>1299 bp
ATGCAAGTTTCAGTTGAAACCACTCAAGGCCTTGGCCGCCGTGTAACGATTACTATCGCT
GCTGACAGCATCGAGACCGCTGTTAAAAGCGAGCTGGTCAACGTTGCGAAAAAAGTACGT
ATTGACGGCTTCCGCAAAGGCAAAGTGCCAATGAATATCGTTGCTCAGCGTTATGGCGCG
TCTGTACGCCAGGACGTTCTGGGTGACCTGATGAGCCGTAACTTCATTGACGCCATCATT
AAAGAAAAAATCAATCCGGCTGGCGCACCGACTTATGTTCCGGGCGAATACAAGCTGGGT
GAAGACTTCACTTACTCTGTAGAGTTTGAAGTTTATCCGGAAGTTGAACTCGAGGGTCTG
GAAGCGATCGAAGTTGAAAAACCGATCGTTGAAGTGACCGACGCTGACGTTGACGGCATG
CTGGATACTCTGCGTAAACAGCAGGCGACCTGGAAAGAAAAAGACGGCGCTGTTGAAGCA
GAAGACCGCGTAACCATCGACTTCACCGGTTCTGTAGACGGCGAAGAGTTCGAAGGCGGT
AAAGCGTCTGATTTCGTACTGGCGATGGGCCAGGGTCGTATGATCCCGGGCTTTGAAGAC
GGTATCAAAGGCCACAAAGCTGGCGAAGAGTTCACCATCGACGTGACCTTCCCGGAAGAA
TACCACGCAGAAAACCTGAAAGGTAAAGCAGCGAAATTCGCTATCAACCTGAAGAAAGTT
GAAGAGCGTGAACTGCCGGAACTGACTGCAGAATTCATCAAACGTTTCGGCGTTGAAGAT
GGTTCCGTAGAAGGTCTGCGCGCTGAAGTGCGTAAAAACATGGAGCGCGAGCTGAGAGCG
CCATCCGTAACCGCGTTAAGTTCTCAGGCGATCGAAGGTCTGGTAAAAGCTAACGACATC
GACGTACCGGCTGCGCTGATCGACAGCGAAATCGACGTTCTGCGTCGCCAGGCTGCACAG
CGTTTCGGTGGCAACGAAAAACAAGCTCTGGAACTGCCGCGCGAACTGTTCGAAGAACAG
GCTAAACGCCGCGTAGTTGTTGGCCTGCTGCTGGGCGAAGTTATCCGCACCAACGAGCTG
AAAGCTGACGAAGAGCGCGTGAAAGGCCTGATCGAAGAGATGGCTTCTGCGTACGAAGAT
CCGAAAGAAGTTATCGAGTTCTACAGCAAAAACAAAGAACTGATGGACAACATGCGCAAT
GTTGCTCTGGAAGAACAGGCTGTTGAAGCTGTACTGGCGAAAGCGAAAGTGACTGAAAAA
GAAACCACTTTCAACGAGCTGATGAACCAGCAGGCGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:432
Protein Molecular Weight:48192
Protein Theoretical pI:5
PDB File:1W26
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Trigger factor
MQVSVETTQGLGRRVTITIAADSIETAVKSELVNVAKKVRIDGFRKGKVPMNIVAQRYGA
SVRQDVLGDLMSRNFIDAIIKEKINPAGAPTYVPGEYKLGEDFTYSVEFEVYPEVELQGL
EAIEVEKPIVEVTDADVDGMLDTLRKQQATWKEKDGAVEAEDRVTIDFTGSVDGEEFEGG
KASDFVLAMGQGRMIPGFEDGIKGHKAGEEFTIDVTFPEEYHAENLKGKAAKFAINLKKV
EERELPELTAEFIKRFGVEDGSVEGLRAEVRKNMERELKSAIRNRVKSQAIEGLVKANDI
DVPAALIDSEIDVLRRQAAQRFGGNEKQALELPRELFEEQAKRRVVVGLLLGEVIRTNEL
KADEERVKGLIEEMASAYEDPKEVIEFYSKNKELMDNMRNVALEEQAVEAVLAKAKVTEK
ETTFNELMNQQA
References
External Links:
ResourceLink
Uniprot ID:P0A850
Uniprot Name:TIG_ECOLI
GenBank Gene ID:M34066
Genebank Protein ID:147989
PDB ID:1W26
CCDB:TIG_ECOLI
General Reference:
  • Aldea, M., Garrido, T., Hernandez-Chico, C., Vicente, M., Kushner, S. R. (1989). "Induction of a growth-phase-dependent promoter triggers transcription of bolA, an Escherichia coli morphogene." EMBO J 8:3923-3931. Pubmed: 2684651
  • Blaha, G., Wilson, D. N., Stoller, G., Fischer, G., Willumeit, R., Nierhaus, K. H. (2003). "Localization of the trigger factor binding site on the ribosomal 50S subunit." J Mol Biol 326:887-897. Pubmed: 12581648
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Buskiewicz, I., Deuerling, E., Gu, S. Q., Jockel, J., Rodnina, M. V., Bukau, B., Wintermeyer, W. (2004). "Trigger factor binds to ribosome-signal-recognition particle (SRP) complexes and is excluded by binding of the SRP receptor." Proc Natl Acad Sci U S A 101:7902-7906. Pubmed: 15148364
  • Crooke, E., Guthrie, B., Lecker, S., Lill, R., Wickner, W. (1988). "ProOmpA is stabilized for membrane translocation by either purified E. coli trigger factor or canine signal recognition particle." Cell 54:1003-1011. Pubmed: 2843289
  • Guthrie, B., Wickner, W. (1990). "Trigger factor depletion or overproduction causes defective cell division but does not block protein export." J Bacteriol 172:5555-5562. Pubmed: 2211496
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Kramer, G., Rauch, T., Rist, W., Vorderwulbecke, S., Patzelt, H., Schulze-Specking, A., Ban, N., Deuerling, E., Bukau, B. (2002). "L23 protein functions as a chaperone docking site on the ribosome." Nature 419:171-174. Pubmed: 12226666
  • Link, A. J., Robison, K., Church, G. M. (1997). "Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12." Electrophoresis 18:1259-1313. Pubmed: 9298646
  • Maurizi, M. R., Clark, W. P., Katayama, Y., Rudikoff, S., Pumphrey, J., Bowers, B., Gottesman, S. (1990). "Sequence and structure of Clp P, the proteolytic component of the ATP-dependent Clp protease of Escherichia coli." J Biol Chem 265:12536-12545. Pubmed: 2197275
  • Patzelt, H., Kramer, G., Rauch, T., Schonfeld, H. J., Bukau, B., Deuerling, E. (2002). "Three-state equilibrium of Escherichia coli trigger factor." Biol Chem 383:1611-1619. Pubmed: 12452438
  • Stoller, G., Tradler, T., Rucknagel, K. P., Rahfeld, J. -. U., Fischer, G. (1996). "An 11.8 kDa proteolytic fragment of the E. coli trigger factor represents the domain carrying the peptidyl-prolyl cis/trans isomerase activity." FEBS Lett 384:117-122. Pubmed: 8612805
  • Ullers, R. S., Houben, E. N., Raine, A., ten Hagen-Jongman, C. M., Ehrenberg, M., Brunner, J., Oudega, B., Harms, N., Luirink, J. (2003). "Interplay of signal recognition particle and trigger factor at L23 near the nascent chain exit site on the Escherichia coli ribosome." J Cell Biol 161:679-684. Pubmed: 12756233
  • Valent, Q. A., Kendall, D. A., High, S., Kusters, R., Oudega, B., Luirink, J. (1995). "Early events in preprotein recognition in E. coli: interaction of SRP and trigger factor with nascent polypeptides." EMBO J 14:5494-5505. Pubmed: 8521806