| Identification |
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| Name: | UvrABC system protein B |
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| Synonyms: | Not Available |
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| Gene Name: | uvrB |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | SOS response |
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| Specific Function: | The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | |
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| Metabolites: | |
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| GO Classification: | | Function |
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| ATP binding | | cytoplasm | | DNA binding | | excinuclease ABC activity | | excinuclease repair complex | | helicase activity | | nucleotide-excision repair | | SOS response |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >2022
atgagtaaaccgttcaaactgaattccgcttttaaaccttctggcgatcagccagaggcg
attcgacgtctcgaagaggggctggaagatggcctggcgcaccagacgttacttggcgtg
actggctcagggaaaaccttcaccattgccaatgtcattgctgaccttcagcgcccaacc
atggtacttgcgcccaacaaaacgctggcggcccagctgtatggcgaaatgaaagagttc
ttcccggaaaacgcggtggaatatttcgtttcctactacgactactatcagccggaagcc
tatgtaccgagttccgacactttcattgagaaagatgcctcggttaacgaacatattgag
cagatgcgtttgtccgccaccaaagcgatgctggagcggcgtgatgtggttgtggtggcg
tctgtttccgcgatttatggtctgggcgatcctgatttatatctcaagatgatgctccat
ctcacggtcggtatgattatcgatcagcgcgcgattctgcgccgactggcggagctgcaa
tacgctcgtaatgatcaagcattccagcgtggtactttccgcgttcgtggcgaggtgata
gatatcttcccggcagaatcggatgacattgcacttcgcgtggaactgtttgacgaggaa
gtggaacgattgtcgttatttgacccgctgaccgggcagattgtttccactattccacgt
tttaccatctacccgaaaacgcactacgtcacaccgcgcgagcgcatcgtacaggcgatg
gaggagatcaaagaagagctggccgccagacgcaaagtgctgttggaaaacaacaaactg
ctggaagagcagcggctgacccagcgtacccagtttgatctggagatgatgaacgagctg
ggctactgttcggggattgaaaactactcgcgcttcctctccggtcgtggaccgggtgag
ccaccgccgacgctgtttgattacctgcctgccgatgggctgctggtcgtcgatgaatct
cacgtcaccattccacaaattggcggcatgtatcgcggtgaccgggcgcgtaaagagaca
ctggtggagtacggcttccgcctgccatcagcgctggataaccgtccgcttaagtttgaa
gagttcgaagcattagcgccgcaaaccatctatgtttcggcgacgccgggtaattacgag
ctggaaaaatccggcggcgatgtggtggatcaggtggtgcgtccaaccggattgcttgac
ccgattatcgaagtgcggccggtggcgacacaggttgatgatcttctttcggagattcgt
cagcgagcggcaattaacgaacgcgtactggtcaccacactgaccaagcggatggcggaa
gatcttaccgaatatctcgaagaacatggcgagcgcgtgcgttatcttcactcagatatc
gacaccgtcgaacgtatggagattatccgcgacttgcgtctgggtgagttcgacgtgctg
gtagggatcaacttactgcgcgaaggtctggatatgccggaagtgtcgctggtggcgatc
ctcgacgctgacaaagaaggcttcctgcgttccgaacgttcgttgatccagaccattggt
cgtgcggcacgtaacgttaacggtaaagcgattctctacggcgataagatcaccccatca
atggcgaaagcgattggcgaaaccgaacgtcgccgtgagaaacagcagaagtacaacgag
gaacacggaattacgccgcaaggcttgaacaagaaagtggtcgatatcctggcgctgggg
cagaacattgccaaaaccaaagcgaagggcagaggaaaatcgcgcccgattgttgagccg
gataatgtgccgatggatatgtcgcctaaagcgttgcagcagaaaatccatgagctggaa
gggttgatgatgcaacacgcgcagaatctggagttcgaagaagcggcgcaaattcgtgac
cagttgcatcagctgcgtgagctgtttatcgcggcatcgtaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 673 |
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| Protein Molecular Weight: | 76225 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 1E52 |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >UvrABC system protein B
MSKPFKLNSAFKPSGDQPEAIRRLEEGLEDGLAHQTLLGVTGSGKTFTIANVIADLQRPT
MVLAPNKTLAAQLYGEMKEFFPENAVEYFVSYYDYYQPEAYVPSSDTFIEKDASVNEHIE
QMRLSATKAMLERRDVVVVASVSAIYGLGDPDLYLKMMLHLTVGMIIDQRAILRRLAELQ
YARNDQAFQRGTFRVRGEVIDIFPAESDDIALRVELFDEEVERLSLFDPLTGQIVSTIPR
FTIYPKTHYVTPRERIVQAMEEIKEELAARRKVLLENNKLLEEQRLTQRTQFDLEMMNEL
GYCSGIENYSRFLSGRGPGEPPPTLFDYLPADGLLVVDESHVTIPQIGGMYRGDRARKET
LVEYGFRLPSALDNRPLKFEEFEALAPQTIYVSATPGNYELEKSGGDVVDQVVRPTGLLD
PIIEVRPVATQVDDLLSEIRQRAAINERVLVTTLTKRMAEDLTEYLEEHGERVRYLHSDI
DTVERMEIIRDLRLGEFDVLVGINLLREGLDMPEVSLVAILDADKEGFLRSERSLIQTIG
RAARNVNGKAILYGDKITPSMAKAIGETERRREKQQKYNEEHGITPQGLNKKVVDILALG
QNIAKTKAKGRGKSRPIVEPDNVPMDMSPKALQQKIHELEGLMMQHAQNLEFEEAAQIRD
QLHQLRELFIAAS |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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