| Identification |
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| Name: | HTH-type transcriptional regulator ArgP |
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| Synonyms: | Not Available |
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| Gene Name: | argP |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | transcription, DNA-templated |
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| Specific Function: | Controls the transcription of genes involved in arginine and lysine metabolism. Activates transcription of several genes, including argO, lysP, lysC, asd, dapB, dapD, lysA, gdhA and argK. Acts by binding directly to their promoter or control region (PubMed:10600368, PubMed:15150242, PubMed:17504942, PubMed:21441513, PubMed:21890697). ArgP dimer by itself is able to bind the argO promoter-operator region to form a binary complex, but the formation of a ternary complex with RNA polymerase is greatly stimulated only in presence of a coeffector. Both arginine and lysine are coeffectors at the argO promoter, but only arginine is competent to activate transcription. Lysine has repressive effects (PubMed:15150242, PubMed:17504942). ArgP also mediates lysine repression of dapB, and gdhA in vivo, but via an alternative mechanism: ArgP binding is directly reduced upon the addition of lysine (PubMed:21890697). Binds in vitro to the promoter region of dnaA and to the upstream region of the nrd promoter, but these genes are probably not regulated by ArgP in vivo (PubMed:9254708, PubMed:9819053, PubMed:21890697). In vitro, binds also to the three 13-mers located in the origin region (oriC) and blocks the initiation of replication (PubMed:1733927). |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| bent DNA binding | | negative regulation of DNA-dependent DNA replication initiation | | negative regulation of transcription, DNA-templated | | positive regulation of transcription, DNA-templated | | sequence-specific DNA binding | | sequence-specific DNA binding transcription factor activity | | transcription, DNA-templated |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >894
atgaaacgcccggactacagaacattacaggcactggatgcggtgatacgtgaacgagga
tttgagcgcgcggcacaaaagctgtgcattacacaatcagccgtctcacagcgcattaag
caactggaaaatatgttcgggcagccgctgttggtgcgtaccgtaccgccgcgcccgacg
gaacaagggcaaaaactgctggcactgctgcgccaggtggagttgctggaagaagagtgg
ctgggcgatgaacaaaccggttcgactccgctgctgctttcactggcggtcaacgccgac
agtctggcgacgtggttgcttcctgcactggctcctgtgttggctgattcgcctatccgc
ctcaacttgcaggtagaagatgaaacccgcactcaggaacgtctgcgccgcggcgaagtg
gtcggcgcggtgagtattcaacatcaggcgctgccgagttgtcttgtcgataaacttggt
gcgctcgactatctgttcgtcagctcaaaaccctttgccgaaaaatatttccctaacggc
gtaacgcgttcggcattactgaaagcgccagtggtcgcgtttgaccatcttgacgatatg
caccaggcctttttgcagcaaaacttcgatctgcctccaggcagcgtgccctgccatatc
gttaattcttcagaagcgttcgtacaacttgctcgccagggcaccacctgctgtatgatc
ccgcacctgcaaatcgagaaagagctggccagcggtgaactgattgacttaacgcctggg
ctatttcaacgacggatgctctactggcaccgctttgctcctgaaagccgcatgatgcgt
aaagtcactgatgcgttactcgattatggtcacaaagtccttcgtcaggattaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 297 |
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| Protein Molecular Weight: | 33471 |
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| Protein Theoretical pI: | Not Available |
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| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >HTH-type transcriptional regulator ArgP
MKRPDYRTLQALDAVIRERGFERAAQKLCITQSAVSQRIKQLENMFGQPLLVRTVPPRPT
EQGQKLLALLRQVELLEEEWLGDEQTGSTPLLLSLAVNADSLATWLLPALAPVLADSPIR
LNLQVEDETRTQERLRRGEVVGAVSIQHQALPSCLVDKLGALDYLFVSSKPFAEKYFPNG
VTRSALLKAPVVAFDHLDDMHQAFLQQNFDLPPGSVPCHIVNSSEAFVQLARQGTTCCMI
PHLQIEKELASGELIDLTPGLFQRRMLYWHRFAPESRMMRKVTDALLDYGHKVLRQD |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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