| Identification |
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| Name: | Outer membrane protein assembly factor BamA |
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| Synonyms: | Not Available |
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| Gene Name: | bamA |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | protein insertion into membrane |
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| Specific Function: | Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.Acts as a receptor for CdiA-EC93, the contact-dependent growth inhibition (CDI) effector of E.coli strain EC93; antibodies against extracellular epitopes decrease CDI. Its role in CDI is independent of the other Bam complex components (PubMed:18761695). Also acts as a receptor for CDI with CdiA from E.coli strain 536 / UPEC, which does not have the same mode of toxicity as CdiA from strain EC93 (PubMed:23469034, PubMed:23882017). Susceptibility to CdiA-EC93 is dependent on E.coli BamA; replacing BamA with the gene from S.typhimurium LT2, E.cloacae ATCC 13047 or D.dadantii 3937 renders cells resistant to CdiA-EC93. Cells with BamA from another bacteria no longer form CdiA-EC93-induced aggregates with EC93 cells. A chimera in which E.cloacae extracellular loops 6 and 7 are replaced with loops 6 and 7 from E.coli is susceptible to CdiA-EC93 and to CdiA-CT from strain 536 / UPEC (PubMed:23882017). |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| Bam protein complex | | cell adhesion | | cell outer membrane | | Gram-negative-bacterium-type cell outer membrane assembly | | integral component of membrane | | protein insertion into membrane |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >2433
atggcgatgaaaaagttgctcatagcgtcgctgctgtttagcagcgccaccgtatacggt
gctgaagggttcgtagtgaaagatattcatttcgaaggccttcagcgtgtcgccgttggt
gcggccctcctcagtatgccggtgcgcacaggcgacacggttaatgatgaagatatcagt
aataccattcgcgctctgtttgctaccggcaactttgaggatgttcgcgtccttcgtgat
ggtgatacccttctggttcaggtaaaagaacgtccgaccattgccagcattactttctcc
ggtaacaaatcggtgaaagatgacatgctgaagcaaaacctcgaggcttctggtgtgcgt
gtgggcgaatccctcgatcgcaccaccattgccgatatcgagaaaggtctggaagacttc
tactacagcgtcggtaaatatagcgccagcgtaaaagctgtcgtgaccccgctgccgcgc
aaccgtgttgacctaaaactggtgttccaggaaggtgtgtcagctgaaatccagcaaatt
aacattgttggtaaccatgctttcaccaccgacgaactgatctctcatttccaactgcgt
gacgaagtgccgtggtggaacgtggtaggcgatcgtaaataccagaaacagaaactggcg
ggcgaccttgaaaccctgcgcagctactatctggatcgcggttatgcccgtttcaacatc
gactctacccaggtcagtctgacgccagataaaaaaggtatttacgtcacggtgaacatc
accgaaggcgatcagtacaagctttctggcgttgaagtgagcggcaaccttgccgggcac
tccgctgaaattgagcagctgactaagatcgagccgggtgagctgtataacggcaccaaa
gtgaccaagatggaagatgacatcaaaaagcttctcggtcgctatggttatgcctatccg
cgcgtacagtcgatgcccgaaattaacgatgccgacaaaaccgttaaattacgtgtgaac
gttgatgcgggtaaccgtttctacgtgcgtaagatccgttttgaaggtaacgatacctcg
aaagatgccgtcctgcgtcgcgaaatgcgtcagatggaaggtgcatggctggggagcgat
ctggtcgatcagggtaaggagcgtctgaatcgtctgggcttctttgaaactgtcgatacc
gatacccaacgtgttccgggtagcccggaccaggttgatgtcgtctacaaggtaaaagag
cgcaacaccggtagcttcaactttggtattggttacggtactgaaagtggcgtgagcttc
caggctggtgtgcagcaggataactggttaggtacaggttatgctgttggtatcaacggg
accaaaaacgattaccagacctatgctgaactgtcggtaaccaacccgtacttcaccgta
gatggcgtaagcctcggtggtcgtctcttctataatgacttccaggcagatgacgccgac
ctgtccgactataccaacaagagttatggtacagacgtgacgttgggcttcccgattaac
gaatataactcgctgcgtgcaggtctgggttatgtacataactccctgtccaacatgcag
cctcaggttgcgatgtggcgttatctgtactctatgggtgaacatccgagcacctctgat
caggataacagcttcaaaacggacgacttcacgttcaactatggttggacctataacaag
cttgaccgtggttacttcccgacagatggttcacgtgtcaacctgaccggtaaagtgacc
attcctggatcggataacgaatactacaaagtgacgttagacacggcgacttatgtgccg
atcgatgacgatcacaaatgggttgttctggggcgtacccgctggggttatggtgatggt
ttaggcggcaaagagatgccgttctacgagaacttctatgccggtggttccagcaccgtg
cgtggcttccagtccaataccattggtccgaaagcagtttacttcccgcatcaggccagt
aattatgatccggactatgattacgaatgtgcgactcaggacggcgcgaaagacctgtgt
aaatcggatgatgctgtaggcggtaacgccatggcggttgccagcctcgagttcatcacc
ccgacgccgtttattagcgataagtatgctaactcggttcgtacttccttcttctgggat
atgggtaccgtttgggatacaaactgggattccagccaatattctggatatccggactat
agtgatccaagcaatatccgtatgtctgcgggtatcgcattacaatggatgtccccattg
gggccgttggtgttctcctacgcccagccgttcaaaaagtacgatggagacaaggcagaa
cagttccagtttaacatcggtaaaacctggtaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 810 |
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| Protein Molecular Weight: | 90552 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 2QCZ |
| Signaling Regions: | |
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| Transmembrane Regions: | - 425-433
- 436-446
- 455-462
- 466-475
- 484-495
- 505-506
- 523-535
- 564-577
- 591-600
- 609-619
- 629-639
- 709-718
- 733-745
- 768-777
- 779-789
- 804-808
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| Protein Sequence: | >Outer membrane protein assembly factor BamA
MAMKKLLIASLLFSSATVYGAEGFVVKDIHFEGLQRVAVGAALLSMPVRTGDTVNDEDIS
NTIRALFATGNFEDVRVLRDGDTLLVQVKERPTIASITFSGNKSVKDDMLKQNLEASGVR
VGESLDRTTIADIEKGLEDFYYSVGKYSASVKAVVTPLPRNRVDLKLVFQEGVSAEIQQI
NIVGNHAFTTDELISHFQLRDEVPWWNVVGDRKYQKQKLAGDLETLRSYYLDRGYARFNI
DSTQVSLTPDKKGIYVTVNITEGDQYKLSGVEVSGNLAGHSAEIEQLTKIEPGELYNGTK
VTKMEDDIKKLLGRYGYAYPRVQSMPEINDADKTVKLRVNVDAGNRFYVRKIRFEGNDTS
KDAVLRREMRQMEGAWLGSDLVDQGKERLNRLGFFETVDTDTQRVPGSPDQVDVVYKVKE
RNTGSFNFGIGYGTESGVSFQAGVQQDNWLGTGYAVGINGTKNDYQTYAELSVTNPYFTV
DGVSLGGRLFYNDFQADDADLSDYTNKSYGTDVTLGFPINEYNSLRAGLGYVHNSLSNMQ
PQVAMWRYLYSMGEHPSTSDQDNSFKTDDFTFNYGWTYNKLDRGYFPTDGSRVNLTGKVT
IPGSDNEYYKVTLDTATYVPIDDDHKWVVLGRTRWGYGDGLGGKEMPFYENFYAGGSSTV
RGFQSNTIGPKAVYFPHQASNYDPDYDYECATQDGAKDLCKSDDAVGGNAMAVASLEFIT
PTPFISDKYANSVRTSFFWDMGTVWDTNWDSSQYSGYPDYSDPSNIRMSAGIALQWMSPL
GPLVFSYAQPFKKYDGDKAEQFQFNIGKTW |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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