| Identification |
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| Name: | Lon protease |
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| Synonyms: | Not Available |
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| Gene Name: | lon |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | response to heat |
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| Specific Function: | ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins, including some antitoxins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. Endogenous substrates include the regulatory proteins RcsA and SulA, the transcriptional activator SoxS, UmuD and antitoxins CcdA, HipB and MazE (PubMed:8022284, PubMed:16460757, PubMed:22720069, PubMed:24375411). Its overproduction specifically inhibits translation through at least two different pathways, one of them being the YoeB-YefM toxin-antitoxin system (PubMed:15009896). |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| ATP binding | | ATP-dependent peptidase activity | | ATPase activity | | cellular response to stress | | cytoplasm | | DNA binding | | misfolded or incompletely synthesized protein catabolic process | | peptidase activity | | proteolysis | | response to heat | | sequence-specific DNA binding | | serine-type endopeptidase activity |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >2355
atgaatcctgagcgttctgaacgcattgaaatccccgtattgccgctgcgcgatgtggtg
gtttatccgcacatggtcatccccttatttgtcgggcgggaaaaatctatccgttgtctg
gaagcggcgatggaccatgataaaaaaattatgctggtcgcgcagaaagaagcttcaacg
gatgagccgggtgtaaacgatcttttcaccgtcgggaccgtggcctctatattgcagatg
ctgaaactgcctgacggcaccgtcaaagtgctggtcgaggggttacagcgcgcgcgtatt
tctgcgctctctgacaatggcgaacacttttctgcgaaggcggagtatctggagtcgccg
accattgatgagcgggaacaggaagtgctggtgcgtactgcaatcagccagttcgaaggc
tacatcaagctgaacaaaaaaatcccaccagaagtgctgacgtcgctgaatagcatcgac
gatccggcgcgtctggcggataccattgctgcacatatgccgctgaaactggctgacaaa
cagtctgttctggagatgtccgacgttaacgaacgtctggaatatctgatggcaatgatg
gaatcggaaatcgatctgctgcaggttgagaaacgcattcgcaaccgcgttaaaaagcag
atggagaaatcccagcgtgagtactatctgaacgagcaaatgaaagctattcagaaagaa
ctcggtgaaatggacgacgcgccggacgaaaacgaagccctgaagcgcaaaatcgacgcg
gcgaagatgccgaaagaggcaaaagagaaagcggaagcagagttgcagaagctgaaaatg
atgtctccgatgtcggcagaagcgaccgtagtgcgtggttatatcgactggatggtacag
gtgccgtggaatgcgcgtagcaaggtcaaaaaagacctgcgtcaggcgcaggaaatcctt
gataccgaccattatggtctggagcgcgtgaaagatcgaatccttgagtatcttgcggtt
caaagccgtgtcaacaaaatcaagggaccgatcctctgcctggtagggccgccgggggta
ggtaaaacctctcttggtcagtccattgccaaagccaccgggcgtaaatatgtccgtatg
gcgctgggcggcgtgcgtgatgaagcggaaatccgtggtcaccgccgtacttacatcggt
tctatgccgggtaaactgatccagaaaatggcgaaagtgggcgtgaaaaacccgctgttc
ctgctcgatgagatcgacaaaatgtcttctgacatgcgtggcgatccggcctctgcactg
cttgaagtgctggatccagagcagaacgtagcgttcagcgaccactacctggaagtggat
tacgatctcagcgacgtgatgtttgtcgcgacgtcgaactccatgaacattccggcaccg
ctgctggatcgtatggaagtgattcgcctctccggttataccgaagatgaaaaactgaac
atcgccaaacgtcacctgctgccgaagcagattgaacgtaatgcactgaaaaaaggtgag
ctgaccgtcgacgatagcgccattatcggcattattcgttactacacccgtgaggcgggc
gtgcgtggtctggagcgtgaaatctccaaactgtgtcgcaaagcggttaagcagttactg
ctcgataagtcattaaaacatatcgaaattaacggcgataacctgcatgactatctcggt
gttcagcgtttcgactatggtcgcgcggataacgaaaaccgtgtcggtcaggtaaccggt
ctggcgtggacggaagtgggcggtgacttgctgaccattgaaaccgcatgtgttccgggt
aaaggcaaactgacctataccggttcgctcggcgaagtgatgcaggagtccattcaggcg
gcgttaacggtggttcgtgcgcgtgcggaaaaactggggatcaaccctgatttttacgaa
aaacgtgacatccacgtccacgtaccggaaggtgcgacgccgaaagatggtccgagtgcc
ggtattgctatgtgcaccgcgctggtttcttgcctgaccggtaacccggttcgtgccgat
gtggcaatgaccggtgagatcactctgcgtggtcaggtactgccgatcggtggtttgaaa
gaaaaactcctggcagcgcatcgcggcgggattaaaacagtgctaattccgttcgaaaat
aaacgcgatctggaagagattcctgacaacgtaattgccgatctggacattcatcctgtg
aagcgcattgaggaagttctgactctggcgctgcaaaatgaaccgtctggtatgcaggtt
gtgactgcaaaatag |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 784 |
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| Protein Molecular Weight: | 87437 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 1QZM |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Lon protease
MNPERSERIEIPVLPLRDVVVYPHMVIPLFVGREKSIRCLEAAMDHDKKIMLVAQKEAST
DEPGVNDLFTVGTVASILQMLKLPDGTVKVLVEGLQRARISALSDNGEHFSAKAEYLESP
TIDEREQEVLVRTAISQFEGYIKLNKKIPPEVLTSLNSIDDPARLADTIAAHMPLKLADK
QSVLEMSDVNERLEYLMAMMESEIDLLQVEKRIRNRVKKQMEKSQREYYLNEQMKAIQKE
LGEMDDAPDENEALKRKIDAAKMPKEAKEKAEAELQKLKMMSPMSAEATVVRGYIDWMVQ
VPWNARSKVKKDLRQAQEILDTDHYGLERVKDRILEYLAVQSRVNKIKGPILCLVGPPGV
GKTSLGQSIAKATGRKYVRMALGGVRDEAEIRGHRRTYIGSMPGKLIQKMAKVGVKNPLF
LLDEIDKMSSDMRGDPASALLEVLDPEQNVAFSDHYLEVDYDLSDVMFVATSNSMNIPAP
LLDRMEVIRLSGYTEDEKLNIAKRHLLPKQIERNALKKGELTVDDSAIIGIIRYYTREAG
VRGLEREISKLCRKAVKQLLLDKSLKHIEINGDNLHDYLGVQRFDYGRADNENRVGQVTG
LAWTEVGGDLLTIETACVPGKGKLTYTGSLGEVMQESIQAALTVVRARAEKLGINPDFYE
KRDIHVHVPEGATPKDGPSAGIAMCTALVSCLTGNPVRADVAMTGEITLRGQVLPIGGLK
EKLLAAHRGGIKTVLIPFENKRDLEEIPDNVIADLDIHPVKRIEEVLTLALQNEPSGMQV
VTAK |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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