Low molecular weight protein-tyrosine-phosphatase wzb (P0AAB2)

Identification
Name:Low molecular weight protein-tyrosine-phosphatase wzb
Synonyms:Not Available
Gene Name:wzb
Enzyme Class:
Biological Properties
General Function:Involved in protein tyrosine phosphatase activity
Specific Function:Dephosphorylates wzc. Required for the extracellular polysaccharide colanic acid synthesis. Probably involved in the export of colanic acid from the cell to medium
Cellular Location:Cytoplasmic
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
KEGG Reactions:
1.0Protein tyrosine phosphate+1.0Thumb ↔ 1.0Thumb+1.0Thumb
1.0Protein tyrosine phosphate + 1.0Water ↔ 1.0Protein tyrosine + 1.0Phosphate
ReactionCard
Complex Reactions:
1.0Protein tyrosine phosphate+1.0Thumb → 1.0protein tyrosine+1.0Thumb
1.0Protein tyrosine phosphate + 1.0Water → 1.0protein tyrosine + 1.0Inorganic phosphate
ReactionCard
Metabolites:
ECMDB IDNameView
ECMDB21380Inorganic phosphateMetaboCard
ECMDB00494WaterMetaboCard
GO Classification:
Function
catalytic activity
hydrolase activity
hydrolase activity, acting on ester bonds
phosphatase activity
phosphoprotein phosphatase activity
phosphoric ester hydrolase activity
protein tyrosine phosphatase activity
Process
cellular metabolic process
dephosphorylation
metabolic process
phosphate metabolic process
phosphorus metabolic process
protein amino acid dephosphorylation
Gene Properties
Blattner:b2061
Gene OrientationCounterclockwise
Centisome Percentage:45.99
Left Sequence End2133679
Right Sequence End2134122
Gene Sequence:
>444 bp
ATGGCAGAACATGGTGCGCTGGCGACCCTGAAAGATCTGGCAGAAAAAGAGGTAGAGGAT
GCCGCGCGCCTGCTGGGTGAAATGCGTCGCGGATGTCAGCAGGCGGAAGAACAGCTCAAA
ATGCTGATTGATTATCAGAATGAATATCGCAATAACCTCAACAGCGATATGAGTGCCGGG
ATAACCAGCAACCGCTGGATCAACTATCAGCAGTTTATCCAGACGCTGGAAAAAGCCATT
ACTCAGCATCGCCAGCAACTTAATCAGTGGACGCAGAAAGTTGACATTGCCCTGAACAGT
TGGCGAGAAAAAAAACAACGTTTGCAGGCCTGGCAGACACTGCAGGAACGGCAATCCACG
GCGGCACTGCTTGCAGAAAACCGCCTCGATCAGAAAAAGATGGATGAGTTCGCCCAGCGC
GCCGCCATGAGGAAACCTGAATGA
Protein Properties
Pfam Domain Function:
Protein Residues:147
Protein Molecular Weight:16709
Protein Theoretical pI:8
Signaling Regions:
  • None
Transmembrane Regions:
  • None
Protein Sequence:
>Low molecular weight protein-tyrosine-phosphatase wzb
MFNNILVVCVGNICRSPTAERLLQRYHPELKVESAGLGALVGKGADPTAISVAAEHQLSL
EGHCARQISRRLCRNYDLILTMEKRHIERLCEMAPEMRGKVMLFGHWDNECEIPDPYRKS
RETFAAVYTLLERSARQWAQALNAEQV
References
External Links:
ResourceLink
Uniprot ID:P0AAB2
Uniprot Name:WZB_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:1736608
Ecogene ID:EG13567
Ecocyc:EG13567
ColiBase:b2061
Kegg Gene:b2061
EchoBASE ID:EB3337
CCDB:WZB_ECOLI
BacMap:16130001
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Stevenson, G., Andrianopoulos, K., Hobbs, M., Reeves, P. R. (1996). "Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid." J Bacteriol 178:4885-4893. Pubmed: 8759852
  • Vincent, C., Doublet, P., Grangeasse, C., Vaganay, E., Cozzone, A. J., Duclos, B. (1999). "Cells of Escherichia coli contain a protein-tyrosine kinase, Wzc, and a phosphotyrosine-protein phosphatase, Wzb." J Bacteriol 181:3472-3477. Pubmed: 10348860
  • Vincent, C., Duclos, B., Grangeasse, C., Vaganay, E., Riberty, M., Cozzone, A. J., Doublet, P. (2000). "Relationship between exopolysaccharide production and protein-tyrosine phosphorylation in gram-negative bacteria." J Mol Biol 304:311-321. Pubmed: 11090276