Identification
Name:Multidrug efflux pump accessory protein AcrZ
Synonyms:Not Available
Gene Name:acrZ
Enzyme Class:Not Available
Biological Properties
General Function:response to antibiotic
Specific Function:AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with a broad substrate specificity. This protein binds to AcrB and is required for efflux of some but not all substrates, suggesting it may influence the specificity of drug export.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
cell outer membrane
cellular response to cell envelope stress
drug transmembrane transporter activity
integral component of membrane
plasma membrane
response to antibiotic
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>150
atgttagagttattaaaaagtctggtattcgccgtaatcatggtacctgtcgtgatggcc
atcatcctgggtctgatttacggtcttggtgaagtattcaacatcttttctggtgttggt
aaaaaagaccagcccggacaaaatcattga
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:49
Protein Molecular Weight:5300
Protein Theoretical pI:Not Available
PDB File:4C48
Signaling Regions:Not Available
Transmembrane Regions:
  • 8-28
Protein Sequence:
>Multidrug efflux pump accessory protein AcrZ
MLELLKSLVFAVIMVPVVMAIILGLIYGLGEVFNIFSGVGKKDQPGQNH
References
External Links:
ResourceLink
Uniprot ID:P0AAW9
Uniprot Name:ACRZ_ECOLI
PDB ID:4C48
CCDB:ACRZ_ECOLI
General Reference:Not Available