Identification
Name:Nitrogen regulatory protein P-II 2
Synonyms:Not Available
Gene Name:glnK
Enzyme Class:Not Available
Biological Properties
General Function:transcription, DNA-templated
Specific Function:P-II indirectly controls the transcription of the glutamine synthetase gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of GlnA. When P-II is uridylylated to P-II-UMP, these events are reversed. When the ratio of Gln to 2-ketoglutarate decreases, P-II is uridylylated to P-II-UMP, which causes the deadenylation of glutamine synthetase by GlnE, so activating the enzyme (By similarity).
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
enzyme regulator activity
identical protein binding
nucleotide binding
positive regulation of nitrogen utilization
regulation of transcription, DNA-templated
transcription, DNA-templated
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>339
atgaagctggtgaccgtgataatcaaaccattcaagctggaagacgttcgtgaagcgtta
tcttccattggtattcagggcctgaccgtcaccgaagtgaaaggtttcgggcgtcagaaa
gggcatgccgagctgtaccggggggcggaatacagcgtcaatttcctgccaaaagtaaaa
attgatgtggcgattgctgatgaccaactcgatgaagtgatcgatatcgtcagtaaggcg
gcttacaccggaaaaattggcgacggcaaaatcttcgtcgctgaattgcaacgcgtcatt
cgtattcgtaccggcgaagccgacgaagcggcgctgtaa
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:112
Protein Molecular Weight:12259
Protein Theoretical pI:Not Available
PDB File:1GNK
Signaling Regions:Not Available
Transmembrane Regions:Not Available
Protein Sequence:
>Nitrogen regulatory protein P-II 2
MKLVTVIIKPFKLEDVREALSSIGIQGLTVTEVKGFGRQKGHAELYRGAEYSVNFLPKVK
IDVAIADDQLDEVIDIVSKAAYTGKIGDGKIFVAELQRVIRIRTGEADEAAL
References
External Links:
ResourceLink
Uniprot ID:P0AC55
Uniprot Name:GLNK_ECOLI
PDB ID:1GNK
CCDB:GLNK_ECOLI
General Reference:Not Available