Identification
Name:Hemolysin expression-modulating protein Hha
Synonyms:Not Available
Gene Name:hha
Enzyme Class:Not Available
Biological Properties
General Function:transcription, DNA-templated
Specific Function:Down-regulates hemolysin expression, in complex with H-NS, and can also stimulate transposition events in vivo. Binds DNA and influences DNA topology in response to environmental stimuli. Involved in persister cell formation, acting downstream of mRNA interferase (toxin) MqsR. Decreases biofilm formation by repressing the transcription of fimbrial genes fimA and ihfA, and by repressing the transcription of tRNAs corresponding to rare codons, which are abundant in type 1 fimbrial genes.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
DNA binding
regulation of gene expression
regulation of transcription, DNA-templated
transcription, DNA-templated
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>219
atgtccgaaaaacctttaacgaaaaccgattatttaatgcgtttacgtcgttgccagaca
attgacacgctggagcgtgttatcgagaaaaataaatacgaattatcagataatgaactg
gcggtattttactcagccgcagatcaccgcctcgccgaattgaccatgaataaactgtac
gacaagatcccttcctcagtatggaaatttattcgctaa
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:72
Protein Molecular Weight:8627
Protein Theoretical pI:Not Available
PDB File:1JW2
Signaling Regions:Not Available
Transmembrane Regions:Not Available
Protein Sequence:
>Hemolysin expression-modulating protein Hha
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLY
DKIPSSVWKFIR
References
External Links:
ResourceLink
Uniprot ID:P0ACE3
Uniprot Name:HHA_ECOLI
PDB ID:1JW2
CCDB:HHA_ECOLI
General Reference:Not Available