| Identification |
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| Name: | Catabolite repressor/activator |
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| Synonyms: | Not Available |
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| Gene Name: | cra |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | transcription, DNA-templated |
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| Specific Function: | Global transcriptional regulator, which plays an important role in the regulation of carbon metabolism. Activates transcription of genes encoding biosynthetic and oxidative enzymes (involved in Krebs cycle, glyoxylate shunt and gluconeogenesis, such as ppsA and fbp). Represses genes involved in sugar catabolism, such as fruB, pfkA, pykF and adhE. Binds asymmetrically to the two half-sites of its operator. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| DNA binding | | glycolytic process | | regulation of transcription, DNA-templated | | response to fructose | | sequence-specific DNA binding transcription factor activity | | transcription, DNA-templated |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >1005
gtgaaactggatgaaatcgctcggctggcgggagtgtcgcggaccactgcaagctatgtt
attaacggcaaagcgaagcaataccgtgtgagcgacaaaaccgttgaaaaagtcatggct
gtggtgcgtgagcacaattaccacccgaacgccgtggcagctgggcttcgtgctggacgc
acacgttctattggtcttgtgatccccgatctggagaacaccagctatacccgcatcgct
aactatcttgaacgccaggcgcggcaacggggttatcaactgctgattgcctgctcagaa
gatcagccagacaacgaaatgcggtgcattgagcaccttttacagcgtcaggttgatgcc
attattgtttcgacgtcgttgcctcctgagcatcctttttatcaacgctgggctaacgac
ccgttcccgattgtcgcgctggaccgcgccctcgatcgtgaacacttcaccagcgtggtt
ggtgccgatcaggatgatgccgaaatgctggcggaagagttacgtaagtttcccgccgag
acggtgctttatcttggtgcgctaccggagctttctgtcagcttcctgcgtgaacaaggt
ttccgtactgcctggaaagatgatccgcgcgaagtgcatttcctgtatgccaacagctat
gagcgggaggcggctgcccagttattcgaaaaatggctggaaacgcatccgatgccgcag
gcgctgttcacaacgtcgtttgcgttgttgcaaggagtgatggatgtcacgctgcgtcgc
gacggcaaactgccttctgacctggcaattgccacctttggcgataacgaactgctcgac
ttcttacagtgtccggtgctggcagtggctcaacgtcaccgcgatgtcgcagagcgtgtg
ctggagattgtcctggcaagcctggacgaaccgcgtaagccaaaacctggtttaacgcgc
attaaacgtaatctctatcgccgcggcgtgctcagccgtagctaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 334 |
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| Protein Molecular Weight: | 37998 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 1UXC |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Catabolite repressor/activator
MKLDEIARLAGVSRTTASYVINGKAKQYRVSDKTVEKVMAVVREHNYHPNAVAAGLRAGR
TRSIGLVIPDLENTSYTRIANYLERQARQRGYQLLIACSEDQPDNEMRCIEHLLQRQVDA
IIVSTSLPPEHPFYQRWANDPFPIVALDRALDREHFTSVVGADQDDAEMLAEELRKFPAE
TVLYLGALPELSVSFLREQGFRTAWKDDPREVHFLYANSYEREAAAQLFEKWLETHPMPQ
ALFTTSFALLQGVMDVTLRRDGKLPSDLAIATFGDNELLDFLQCPVLAVAQRHRDVAERV
LEIVLASLDEPRKPKPGLTRIKRNLYRRGVLSRS |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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