| Identification |
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| Name: | HTH-type transcriptional repressor PurR |
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| Synonyms: | Not Available |
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| Gene Name: | purR |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | transcription, DNA-templated |
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| Specific Function: | Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. In addition, it participates in the regulation or coregulation of genes involved in de novo pyrimidine nucleotide biosynthesis, salvage and uptake (pyrC, pyrD, carAB and codBA), and of several genes encoding enzymes necessary for nucleotide and polyamine biosynthesis (prsA, glyA, gcvTHP, speA, glnB). Binds to a 16-bp palindromic sequence located within the promoter region of pur regulon genes. The consensus binding sequence is 5'-ACGCAAACGTTTTCNT-3'. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| DNA binding | | negative regulation of transcription, DNA-templated | | purine nucleotide biosynthetic process | | sequence-specific DNA binding transcription factor activity | | transcription, DNA-templated |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >1026
atggcaacaataaaagatgtagcgaaacgagcaaacgtttccactacaactgtgtcacac
gtgatcaacaaaacacgtttcgtcgctgaagaaacgcgcaacgccgtgtgggcagcgatt
aaagaattacactactcccctagcgcggtggcgcgtagcctgaaggttaaccacaccaag
tctatcggtttgctggcgaccagcagcgaagcggcctattttgccgagatcattgaagca
gttgaaaaaaattgcttccagaaaggttacaccctgattctgggcaatgcgtggaacaat
cttgagaaacagcgggcttatctgtcgatgatggcgcaaaaacgcgtcgatggtctgctg
gtgatgtgttctgagtacccagagccgttgctggcgatgctggaagagtatcgccatatc
ccaatggtggtcatggactggggtgaagcaaaagctgacttcaccgatgcggtcattgat
aacgcgttcgaaggcggctacatggccgggcgttatctgattgaacgcggtcaccgcgaa
atcggcgtcatccccggcccgctggaacgtaacaccggcgcaggccgccttgccggtttt
atgaaggcgatggaagaagcgatgatcaaggtgccggaaagctggattgtgcagggtgac
tttgaacctgaatccggttatcgcgccatgcagcaaatcctgtcgcagccgcatcgccct
actgccgtcttctgtggtggcgatatcatggcaatgggcgcactttgtgctgctgatgaa
atgggcctgcgcgtcccgcaggatgtttcgctgatcggttatgataacgtgcgcaacgcg
cgctattttacgccggcgctgaccacgatccatcagccaaaagattcgctgggtgaaaca
gcgttcaacatgctgttggatcgtatcgtcaacaaacgtgaagaaccgcagtctattgaa
gtgcatccgcgcttgattgaacgccgctccgtggctgacggcccgttccgcgactatcgt
cgttaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 341 |
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| Protein Molecular Weight: | 38174 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 1BDH |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >HTH-type transcriptional repressor PurR
MATIKDVAKRANVSTTTVSHVINKTRFVAEETRNAVWAAIKELHYSPSAVARSLKVNHTK
SIGLLATSSEAAYFAEIIEAVEKNCFQKGYTLILGNAWNNLEKQRAYLSMMAQKRVDGLL
VMCSEYPEPLLAMLEEYRHIPMVVMDWGEAKADFTDAVIDNAFEGGYMAGRYLIERGHRE
IGVIPGPLERNTGAGRLAGFMKAMEEAMIKVPESWIVQGDFEPESGYRAMQQILSQPHRP
TAVFCGGDIMAMGALCAADEMGLRVPQDVSLIGYDNVRNARYFTPALTTIHQPKDSLGET
AFNMLLDRIVNKREEPQSIEVHPRLIERRSVADGPFRDYRR |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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