ECMDB: Redox-sensitive transcriptional activator SoxR (P0ACS2)

Identification

Name:

Redox-sensitive transcriptional activator SoxR

Synonyms:

Not Available

Gene Name:

soxR

Enzyme Class:

Not Available

Biological Properties

General Function:

transcription, DNA-templated

Specific Function:

Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress. Upon reduction of 2Fe-2S cluster, SoxR reversibly loses its transcriptional activity, but retains its DNA binding affinity.

Cellular Location:

Not Available

SMPDB Pathways:

Not Available

KEGG Pathways:

Not Available

Metabolites:

ECMDB ID	Name	View

GO Classification:

Function
2 iron, 2 sulfur cluster binding
cytoplasm
DNA binding
metal ion binding
regulation of transcription, DNA-templated
response to oxidative stress
transcription, DNA-templated

Gene Properties

Blattner:

Not Available

Gene Orientation

Not Available

Centisome Percentage:

Not Available

Left Sequence End

Not Available

Right Sequence End

Not Available

Gene Sequence:

>465
atggaaaagaaattaccccgcattaaagcgctgctaacccccggcgaagtggcgaaacgc
agcggtgtggcggtatcggcgctgcatttctatgaaagtaaagggttgattaccagtatc
cgtaacagcggcaatcagcggcgatataaacgtgatgtgttgcgatatgttgcaattatc
aaaattgctcagcgtattggcattccgctggcgaccattggtgaagcgtttggcgtgttg
cccgaagggcatacgttaagtgcgaaagagtggaaacagctttcgtcccaatggcgagaa
gagttggatcggcgcattcataccttagtggcgctgcgtgacgaactggacggatgtatt
ggttgtggctgcctttcgcgcagtgattgcccgttgcgtaacccgggcgaccgcttagga
gaagaaggtaccggcgcacgcttgctggaagatgaacaaaactaa

Protein Properties

Pfam Domain Function:

Not Available

Protein Residues:

154

Protein Molecular Weight:

17149

Protein Theoretical pI:

Not Available

PDB File:

2ZHG

Signaling Regions:

Not Available

Transmembrane Regions:

Not Available

Protein Sequence:

>Redox-sensitive transcriptional activator SoxR
MEKKLPRIKALLTPGEVAKRSGVAVSALHFYESKGLITSIRNSGNQRRYKRDVLRYVAII
KIAQRIGIPLATIGEAFGVLPEGHTLSAKEWKQLSSQWREELDRRIHTLVALRDELDGCI
GCGCLSRSDCPLRNPGDRLGEEGTGARLLEDEQN

References

External Links:

Resource	Link
Uniprot ID:	P0ACS2
Uniprot Name:	SOXR_ECOLI
PDB ID:	2ZHG
CCDB:	SOXR_ECOLI

General Reference:

Not Available