Identification
Name:Transcriptional regulatory protein CpxR
Synonyms:Not Available
Gene Name:cpxR
Enzyme Class:Not Available
Biological Properties
General Function:transcription, DNA-templated
Specific Function:Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein. Other downstream effectors may include SrkA (PubMed:23416055).
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:
  • Cationic antimicrobial peptide (CAMP) resistance eco01503
Metabolites:
ECMDB IDNameView
GO Classification:
Function
cytoplasm
DNA binding
negative regulation of transcription, DNA-templated
phosphorelay signal transduction system
positive regulation of transcription, DNA-templated
sequence-specific DNA binding transcription factor activity
transcription, DNA-templated
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>699
atgaataaaatcctgttagttgatgatgaccgagagctgacttccctattaaaggagctg
ctcgagatggaaggcttcaacgtgattgttgcccacgatggggaacaggcgcttgatctt
ctggacgacagcattgatttacttttgcttgacgtaatgatgccgaagaaaaatggtatc
gacacattaaaagcacttcgccagacacaccagacgcctgtcattatgttgacggcgcgc
ggcagtgaacttgatcgcgttctcggccttgagctgggcgcagatgactatctcccgaaa
ccgtttaatgatcgtgagctggtggcacgtattcgcgcgatcctgcgccgttcgcactgg
agcgagcaacagcaaaacaacgacaacggttcaccgacactggaagttgatgccttagtg
ctgaatccaggccgtcaggaagccagcttcgacgggcaaacgctggagttaaccggtact
gagtttaccctgctctatttgctggcacagcatctgggtcaggtggtttcccgtgaacat
ttaagccaggaagtgttgggcaaacgcctgacgcctttcgaccgcgctattgatatgcac
atttccaacctgcgtcgtaaactgccggatcgtaaagatggtcacccgtggtttaaaacc
ttgcgtggtcgcggctatctgatggtttctgcttcatga
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:232
Protein Molecular Weight:26311
Protein Theoretical pI:Not Available
Signaling Regions:Not Available
Transmembrane Regions:Not Available
Protein Sequence:
>Transcriptional regulatory protein CpxR
MNKILLVDDDRELTSLLKELLEMEGFNVIVAHDGEQALDLLDDSIDLLLLDVMMPKKNGI
DTLKALRQTHQTPVIMLTARGSELDRVLGLELGADDYLPKPFNDRELVARIRAILRRSHW
SEQQQNNDNGSPTLEVDALVLNPGRQEASFDGQTLELTGTEFTLLYLLAQHLGQVVSREH
LSQEVLGKRLTPFDRAIDMHISNLRRKLPDRKDGHPWFKTLRGRGYLMVSAS
References
External Links:
ResourceLink
Uniprot ID:P0AE88
Uniprot Name:CPXR_ECOLI
CCDB:CPXR_ECOLI
General Reference:Not Available