| Identification |
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| Name: | Regulator of sigma-E protease RseP |
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| Synonyms: | Not Available |
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| Gene Name: | rseP |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | positive regulation of transcription, DNA-templated |
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| Specific Function: | A site-2 regulated intramembrane protease (S2P) that cleaves the peptide bond between 'Ala-108' and 'Cys-109' in the transmembrane region of RseA. Part of a regulated intramembrane proteolysis (RIP) cascade. Acts on DegS-cleaved RseA to release the cytoplasmic domain of RseA, residue "Val-148" of RseA may be required for this. This provides the cell with sigma-E (RpoE) activity through the proteolysis of RseA. Can also cleave sequences in transmembrane regions of other proteins (such as LacY) as well as liberated signal peptides of beta-lactamase, OmpF, LivK, SecM, PhoA, LivJ, OmpC, Lpp and TorA, probably within the membrane. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| anti-sigma factor antagonist activity | | antisigma factor binding | | integral component of plasma membrane | | metal ion binding | | metalloendopeptidase activity | | positive regulation of transcription, DNA-templated |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >1353
atgctgagttttctctgggatttggcttcgttcatcgttgcactgggtgtacttatcacc
gtgcatgaatttggtcatttctgggttgcccggcgttgtggtgttcgcgttgagcgtttc
tcaatagggtttggtaaggcgctctggcggcgaactgataagctcggcaccgaatatgtt
atcgccctgatcccgttgggcggttatgtcaaaatgctggatgagcgcgcagaaccggtc
gttccggaactccgccaccatgccttcaataataaatctgtcggccaacgagcggcgatt
attgccgcaggtccggttgcaaacttcatttttgctatctttgcctactggctggttttt
attattggtgtgcctggcgtacgtccggtggttggcgaaatagcagccaattcgatagct
gcggaagcacaaattgcaccaggtacggaactaaaagccgtagatggtatcgaaacgcct
gattgggatgccgtgcgtttgcagttggtcgataaaattggcgatgaaagcaccaccatt
acagtagcgccatttggcagcgaccaacggcgggatgtaaagctcgatttacgtcactgg
gcgtttgagcctgataaagaagatccggtatcttcgctggggattcgtcctcgtgggccg
caaattgaacctgtactggaaaatgtgcagccaaactcggcggcaagcaaggcaggtttg
caagcaggcgacaggatcgttaaagtcgatggtcagcccttaacgcagtgggtgaccttt
gtgatgcttgtccgggataacccgggtaaatccttagcgttagaaatcgaaaggcagggg
agtcccttgtctttgacattaatcccggagagtaaaccgggtaatggtaaagcgattggt
tttgtcggtattgagccgaaagtcattcctttgccagatgagtataaagttgtacgccag
tatgggccgttcaacgccatcgtcgaagccacggacaaaacgtggcagctgatgaagctg
acggtcagtatgctgggaaaattgatcaccggtgatgtgaaactgaacaacctcagtggg
ccgatctctatcgccaagggggctgggatgacagcggaactcggggttgtttattacctg
ccgtttcttgcgcttattagcgtgaacttagggataattaacctgtttccgttgcccgta
cttgacggggggcatctgctgttccttgcgatcgaaaagatcaagggcggaccggtatcc
gagcgggttcaagacttttgttatcgcattggctcgattctgctggtgctgttaatgggg
cttgcacttttcaatgatttctctcggttatga |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 450 |
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| Protein Molecular Weight: | 49070 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 2ZPL |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | - 1-21
- 104-124
- 376-396
- 430-450
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| Protein Sequence: | >Regulator of sigma-E protease RseP
MLSFLWDLASFIVALGVLITVHEFGHFWVARRCGVRVERFSIGFGKALWRRTDKLGTEYV
IALIPLGGYVKMLDERAEPVVPELRHHAFNNKSVGQRAAIIAAGPVANFIFAIFAYWLVF
IIGVPGVRPVVGEIAANSIAAEAQIAPGTELKAVDGIETPDWDAVRLQLVDKIGDESTTI
TVAPFGSDQRRDVKLDLRHWAFEPDKEDPVSSLGIRPRGPQIEPVLENVQPNSAASKAGL
QAGDRIVKVDGQPLTQWVTFVMLVRDNPGKSLALEIERQGSPLSLTLIPESKPGNGKAIG
FVGIEPKVIPLPDEYKVVRQYGPFNAIVEATDKTWQLMKLTVSMLGKLITGDVKLNNLSG
PISIAKGAGMTAELGVVYYLPFLALISVNLGIINLFPLPVLDGGHLLFLAIEKIKGGPVS
ERVQDFCYRIGSILLVLLMGLALFNDFSRL |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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