Identification
Name:Chaperone protein Skp
Synonyms:Not Available
Gene Name:skp
Enzyme Class:Not Available
Biological Properties
General Function:protein stabilization
Specific Function:Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm. Required for the efficient release of OmpA from the inner membrane, the maintenance of its solubility in the periplasm, and, in association with lipopolysaccharide (LPS), for the efficient folding and insertion of OmpA into the outer membrane.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
chaperone mediated protein folding requiring cofactor
cytosol
Gram-negative-bacterium-type cell outer membrane assembly
intracellular protein transmembrane transport
lipopolysaccharide binding
outer membrane-bounded periplasmic space
protein folding
protein insertion into membrane from inner side
protein maturation by protein folding
protein stabilization
unfolded protein binding
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>486
gtgaaaaagtggttattagctgcaggtctcggtttagcactggcaacttctgctcaggcg
gctgacaaaattgcaatcgtcaacatgggcagcctgttccagcaggtagcgcagaaaacc
ggtgtttctaacacgctggaaaatgagttcaaaggccgtgccagcgaactgcagcgtatg
gaaaccgatctgcaggctaaaatgaaaaagctgcagtccatgaaagcgggcagcgatcgc
actaagctggaaaaagacgtgatggctcagcgccagacttttgctcagaaagcgcaggct
tttgagcaggatcgcgcacgtcgttccaacgaagaacgcggcaaactggttactcgtatc
cagactgctgtgaaatccgttgccaacagccaggatatcgatctggttgttgatgcaaac
gccgttgcttacaacagcagcgatgtaaaagacatcactgccgacgtactgaaacaggtt
aaataa
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:161
Protein Molecular Weight:17688
Protein Theoretical pI:Not Available
PDB File:1SG2
Signaling Regions:
  • 1-20
Transmembrane Regions:Not Available
Protein Sequence:
>Chaperone protein Skp
MKKWLLAAGLGLALATSAQAADKIAIVNMGSLFQQVAQKTGVSNTLENEFKGRASELQRM
ETDLQAKMKKLQSMKAGSDRTKLEKDVMAQRQTFAQKAQAFEQDRARRSNEERGKLVTRI
QTAVKSVANSQDIDLVVDANAVAYNSSDVKDITADVLKQVK
References
External Links:
ResourceLink
Uniprot ID:P0AEU7
Uniprot Name:SKP_ECOLI
PDB ID:1SG2
CCDB:SKP_ECOLI
General Reference:Not Available