Identification
Name:Regulator of RpoS
Synonyms:Not Available
Gene Name:rssB
Enzyme Class:Not Available
Biological Properties
General Function:regulation of nucleic acid-templated transcription
Specific Function:Regulates the turnover of the sigma S factor (RpoS) by promoting its proteolysis in exponentially growing cells. Acts by binding and delivering RpoS to the ClpXP protease. RssB is not co-degraded with RpoS, but is released from the complex and can initiate a new cycle of RpoS recognition and degradation. In stationary phase, could also act as an anti-sigma factor and reduce the ability of RpoS to activate gene expression. Is also involved in the regulation of the mRNA polyadenylation pathway during stationary phase, probably by maintaining the association of PcnB with the degradosome.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
intracellular
phosphorelay signal transduction system
positive regulation of proteolysis
protein destabilization
regulation of gene expression
regulation of nucleic acid-templated transcription
sigma factor antagonist activity
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>1014
atgacgcagccattggtcggaaaacagattctcattgttgaagatgagcaggtatttcgc
tcgcttctggattcatggttttcctcattgggagcgacaacggtactggcggctgatggg
gtggatgcccttgagttgctgggaggtttcactccagacctgatgatatgtgatatcgcg
atgccacgaatgaacgggcttaaactgctggagcatatacgtaacagaggcgaccagacc
ccagttctggtgatatctgccactgaaaatatggcagatattgccaaagcgttacgtctg
ggcgttgaagatgttttgctgaaaccagttaaagatctgaatcgcttgcgcgagatggtt
tttgcctgtctctatcccagcatgtttaattcgcgcgttgaggaagaggaaaggcttttt
cgcgactgggatgcaatggttgataaccctgccgcagcggcgaaattattacaggaacta
caaccgccggttcagcaggtgatttcccattgccgggttaattatcgtcaattggttgcc
gcggacaaacccggcctggtgcttgatattgccgcactttcggaaaacgatctggcattt
tattgccttgatgtcacccgagctggacataatggcgtacttgctgccttgttattacgc
gcattgtttaacggattattacaggaacagcttgcacaccaaaatcaacggttgccagag
ttgggcgcgttattgaagcaggtaaaccatttacttcgtcaggccaatctgccggggcag
tttccgctattagttggctattatcatcgcgaactgaaaaatctcattctggtttctgcg
ggtctgaatgcgacgttaaataccggcgaacaccaggtgcaaatcagtaatggtgttccg
ttaggcactttaggtaacgcttatttgaatcaattgagccagcgatgcgatgcctggcaa
tgccaaatatggggaaccggtggtcgactgcgcttgatgttgtctgcagaatga
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:337
Protein Molecular Weight:37301
Protein Theoretical pI:Not Available
PDB File:3EOD
Signaling Regions:Not Available
Transmembrane Regions:Not Available
Protein Sequence:
>Regulator of RpoS
MTQPLVGKQILIVEDEQVFRSLLDSWFSSLGATTVLAADGVDALELLGGFTPDLMICDIA
MPRMNGLKLLEHIRNRGDQTPVLVISATENMADIAKALRLGVEDVLLKPVKDLNRLREMV
FACLYPSMFNSRVEEEERLFRDWDAMVDNPAAAAKLLQELQPPVQQVISHCRVNYRQLVA
ADKPGLVLDIAALSENDLAFYCLDVTRAGHNGVLAALLLRALFNGLLQEQLAHQNQRLPE
LGALLKQVNHLLRQANLPGQFPLLVGYYHRELKNLILVSAGLNATLNTGEHQVQISNGVP
LGTLGNAYLNQLSQRCDAWQCQIWGTGGRLRLMLSAE
References
External Links:
ResourceLink
Uniprot ID:P0AEV1
Uniprot Name:RSSB_ECOLI
PDB ID:3EOD
CCDB:RSSB_ECOLI
General Reference:Not Available