Identification
Name:DNA topoisomerase 4 subunit A
Synonyms:Not Available
Gene Name:parC
Enzyme Class:
Biological Properties
General Function:sister chromatid cohesion
Specific Function:Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. MukB stimulates the relaxation activity of topoisomerase IV and also has a modest effect on decatenation.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
ATP binding
chromosome
chromosome segregation
cytoplasm
DNA binding
DNA topoisomerase complex (ATP-hydrolyzing)
DNA topoisomerase type II (ATP-hydrolyzing) activity
DNA topological change
DNA unwinding involved in DNA replication
extrinsic component of plasma membrane
nucleoid
plasmid partitioning
sister chromatid cohesion
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>2259
atgagcgatatggcagagcgccttgcgctacatgaatttacggaaaacgcctacttaaac
tactccatgtacgtgatcatggaccgtgcgttgccgtttattggtgatggtctgaaacct
gttcagcgccgcattgtgtatgcgatgtctgaactgggcctgaatgccagcgccaaattt
aaaaaatcggcccgtaccgtcggtgacgtactgggtaaataccatccgcacggcgatagc
gcctgttatgaagcgatggtcctgatggcgcaaccgttctcttaccgttatccgctggtt
gatggtcaggggaactggggcgcgccggacgatccgaaatcgttcgcggcaatgcgttac
accgaatcccggttgtcgaaatattccgagctgctattgagcgagctggggcaggggacg
gctgactgggtgccaaacttcgacggcactttgcaggagccgaaaatgctacctgcccgt
ctgccaaacattttgcttaacggcaccaccggtattgccgtcggcatggcgaccgatatt
ccaccgcataacctgcgtgaagtggctcaggcggcaatcgcattaatcgaccagccgaaa
accacgctcgatcagctgctggatatcgtgcaggggccggattatccgactgaagcggaa
attatcacttcgcgcgccgagatccgtaaaatctacgagaacggacgtggttcagtgcgt
atgcgcgcggtgtggaagaaagaagatggcgcggtggttatcagcgcattgccgcatcag
gtttcaggtgcgcgcgtactggagcaaattgctgcgcaaatgcgcaacaaaaagctgccg
atggttgacgatctgcgcgatgaatctgaccacgagaacccgacccgcctggtgattgtg
ccgcgttccaaccgcgtggatatggatcaggtgatgaaccacctcttcgctaccaccgat
ctggaaaagagctatcgtattaaccttaatatgatcggtctggatggtcgtccggcggtg
aaaaacctgctggaaatcctctccgaatggctggtgttccgccgcgataccgtgcgccgc
cgactgaactatcgtctggagaaagtcctcaagcgcctgcatatcctcgaaggtttgctg
gtggcgtttctcaatatcgacgaagtgattgagatcattcgtaatgaagatgaaccgaaa
ccggcgctgatgtcgcggtttggccttacggaaacccaggcggaagcgatcctcgaactg
aaactgcgtcatcttgccaaactggaagagatgaagattcgcggtgagcagagtgaactg
gaaaaagagcgcgaccagttgcagggcattttggcttccgagcgtaaaatgaataacctg
ctgaagaaagaactgcaggcagacgcgcaagcctacggtgacgatcgtcgttcgccgttg
caggaacgcgaagaagcgaaagcgatgagcgagcacgacatgctgccgtctgaacctgtc
accattgtgctgtcgcagatgggctgggtacgcagcgctaaaggccatgatatcgacgcg
ccgggcctgaattataaagcgggtgatagcttcaaagcggcggtgaaaggtaagagcaac
caaccggtagtgtttgttgattccaccggtcgtagctatgccattgacccgattacgctg
ccgtcggcgcgtggtcagggcgagccgctcaccggcaaattaacgttgccgcctggggcg
accgttgaccatatgctgatggaaagcgacgatcagaaactgctgatggcttccgatgcg
ggttacggtttcgtctgcacctttaacgatctggtggcgcgtaaccgtgcaggtaaggct
ttgatcaccttaccggaaaatgcccatgttatgccgccggtggtgattgaagatgcttcc
gatatgctgctggcaatcactcaggcaggccgtatgttgatgttcccggtaagtgatctg
ccgcagctgtcgaagggcaaaggcaacaagattatcaacattccatcggcagaagccgcg
cgtggagaagatggtctggcgcaattgtacgttctgccgccgcaaagcacgctgaccatt
catgttgggaaacgcaaaattaaactgcgcccggaagagttacagaaagtcactggcgaa
cgtggacgccgcggtacgttgatgcgcggtttgcagcgtatcgatcgtgttgagatcgac
tctcctcgccgtgccagcagcggtgatagcgaagagtaa
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:752
Protein Molecular Weight:83830
Protein Theoretical pI:Not Available
PDB File:1ZVT
Signaling Regions:Not Available
Transmembrane Regions:Not Available
Protein Sequence:
>DNA topoisomerase 4 subunit A
MSDMAERLALHEFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNASAKF
KKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRY
TESRLSKYSELLLSELGQGTADWVPNFDGTLQEPKMLPARLPNILLNGTTGIAVGMATDI
PPHNLREVAQAAIALIDQPKTTLDQLLDIVQGPDYPTEAEIITSRAEIRKIYENGRGSVR
MRAVWKKEDGAVVISALPHQVSGARVLEQIAAQMRNKKLPMVDDLRDESDHENPTRLVIV
PRSNRVDMDQVMNHLFATTDLEKSYRINLNMIGLDGRPAVKNLLEILSEWLVFRRDTVRR
RLNYRLEKVLKRLHILEGLLVAFLNIDEVIEIIRNEDEPKPALMSRFGLTETQAEAILEL
KLRHLAKLEEMKIRGEQSELEKERDQLQGILASERKMNNLLKKELQADAQAYGDDRRSPL
QEREEAKAMSEHDMLPSEPVTIVLSQMGWVRSAKGHDIDAPGLNYKAGDSFKAAVKGKSN
QPVVFVDSTGRSYAIDPITLPSARGQGEPLTGKLTLPPGATVDHMLMESDDQKLLMASDA
GYGFVCTFNDLVARNRAGKALITLPENAHVMPPVVIEDASDMLLAITQAGRMLMFPVSDL
PQLSKGKGNKIINIPSAEAARGEDGLAQLYVLPPQSTLTIHVGKRKIKLRPEELQKVTGE
RGRRGTLMRGLQRIDRVEIDSPRRASSGDSEE
References
External Links:
ResourceLink
Uniprot ID:P0AFI2
Uniprot Name:PARC_ECOLI
PDB ID:1ZVT
CCDB:PARC_ECOLI
General Reference:Not Available