Identification |
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Name: | Negative modulator of initiation of replication |
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Synonyms: | Not Available |
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Gene Name: | seqA |
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Enzyme Class: | Not Available |
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Biological Properties |
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General Function: | regulation of transcription, DNA-templated |
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Specific Function: | Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. Can also bind to hemimethylated GATC sequences outside of oriC region. Binds, with less affinity, to fully methylated GATC sites and affects timing of replication. May play a role in chromosome organization and gene regulation. |
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Cellular Location: | Not Available |
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SMPDB Pathways: | Not Available |
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KEGG Pathways: | Not Available |
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Metabolites: | |
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GO Classification: | Function |
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cytoplasm | DNA binding | identical protein binding | negative regulation of DNA-dependent DNA replication initiation | regulation of transcription, DNA-templated |
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Gene Properties |
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Blattner: | Not Available |
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Gene Orientation | Not Available |
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Centisome Percentage: | Not Available |
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Left Sequence End | Not Available |
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Right Sequence End | Not Available |
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Gene Sequence: | >546
atgaaaacgattgaagttgatgatgaactctacagctatattgccagccacactaagcat
atcggcgagagcgcatccgacattttacggcgtatgttgaaattttccgccgcatcacag
cctgctgctccggtgacgaaagaggttcgcgttgcgtcacctgctatcgtcgaagcgaag
ccggtcaaaacgattaaagacaaggttcgcgcaatgcgtgaacttctgctttcggatgaa
tacgcagagcaaaagcgagcggtcaatcgctttatgctgctgttgtctacactatattct
cttgacgcccaggcgtttgccgaagcaacggaatcgttgcacggtcgtacacgcgtttac
tttgcggcagatgaacaaacgctgctgaaaaatggtaatcagaccaagccgaaacatgtg
ccaggcacgccgtattgggtgatcaccaacaccaacaccggccgtaaatgcagcatgatc
gaacacatcatgcagtcgatgcaattcccggcggaattgattgagaaggtttgcggaact
atctaa |
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Protein Properties |
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Pfam Domain Function: | Not Available |
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Protein Residues: | Not Available |
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Protein Molecular Weight: | 20315 |
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Protein Theoretical pI: | Not Available |
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PDB File: | 1IU3 |
Signaling Regions: | Not Available |
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Transmembrane Regions: | Not Available |
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Protein Sequence: | >Negative modulator of initiation of replication
MKTIEVDDELYSYIASHTKHIGESASDILRRMLKFSAASQPAAPVTKEVRVASPAIVEAK
PVKTIKDKVRAMRELLLSDEYAEQKRAVNRFMLLLSTLYSLDAQAFAEATESLHGRTRVY
FAADEQTLLKNGNQTKPKHVPGTPYWVITNTNTGRKCSMIEHIMQSMQFPAELIEKVCGT
I |
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References |
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External Links: | |
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General Reference: | Not Available |
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