| Identification |
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| Name: | HTH-type transcriptional regulator IscR |
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| Synonyms: | Not Available |
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| Gene Name: | iscR |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | transcription, DNA-templated |
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| Specific Function: | Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. Transcriptional repressor of the iscRSUA operon, which is involved in the assembly of Fe-S clusters into Fe-S proteins. In its apoform, under conditions of oxidative stress or iron deprivation, it activates the suf operon, which is a second operon involved in the assembly of Fe-S clusters. Represses its own transcription as well as that of toxin rnlA. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| 2 iron, 2 sulfur cluster binding | | double-stranded DNA binding | | iron ion binding | | regulation of transcription, DNA-templated | | sequence-specific DNA binding transcription factor activity | | transcription, DNA-templated |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >489
atgagactgacatctaaagggcgctatgccgtgaccgcaatgcttgacgttgcgctcaac
tctgaagcgggcccggtaccgttggctgatatttccgaacgtcagggaatttccctttct
tatctggaacaactgttttcccgtctgcgtaaaaatggtctggtttccagcgtacgtgga
ccaggcggtggttatctgttaggcaaagatgccagcagcatcgccgttggcgaagtaatt
agcgccgttgacgaatctgtagatgccacccgttgtcagggtaaaggcggctgccagggc
ggcgataaatgcctgacccacgcgctgtggcgtgatttgagcgaccgtctcaccggtttt
ctcaacaacattactttaggcgaactggttaataaccaggaagtgctggatgtgtctggt
cgtcagcatactcacgacgcgccacgcacccgcacacaagacgcgatcgacgttaagtta
cgcgcttaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 162 |
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| Protein Molecular Weight: | 17336 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 4HF0 |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >HTH-type transcriptional regulator IscR
MRLTSKGRYAVTAMLDVALNSEAGPVPLADISERQGISLSYLEQLFSRLRKNGLVSSVRG
PGGGYLLGKDASSIAVGEVISAVDESVDATRCQGKGGCQGGDKCLTHALWRDLSDRLTGF
LNNITLGELVNNQEVLDVSGRQHTHDAPRTRTQDAIDVKLRA |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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