| Identification |
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| Name: | Periplasmic serine endoprotease DegP |
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| Synonyms: | Not Available |
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| Gene Name: | degP |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | response to temperature stimulus |
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| Specific Function: | DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolytic activity is essential for the survival of cells at elevated temperatures. It can degrade IciA, Ada, casein, globin and PapA. DegP shares specificity with DegQ. DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP). |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | - Cationic antimicrobial peptide (CAMP) resistance eco01503
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| Metabolites: | |
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| GO Classification: | | Function |
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| identical protein binding | | misfolded or incompletely synthesized protein catabolic process | | outer membrane-bounded periplasmic space | | plasma membrane | | protein folding | | proteolysis | | response to oxidative stress | | response to temperature stimulus | | serine-type endopeptidase activity |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >1425
atgaaaaaaaccacattagcactgagtgcactggctctgagtttaggtttggcgttatct
ccgctctctgcaacggcggctgagacttcttcagcaacgacagcccagcagatgccaagc
cttgcaccgatgctcgaaaaggtgatgccttcagtggtcagcattaacgtagaaggtagc
acaaccgttaatacgccgcgtatgccgcgtaatttccagcagttcttcggtgatgattct
ccgttctgccaggaaggttctccgttccagagctctccgttctgccagggtggccagggc
ggtaatggtggcggccagcaacagaaattcatggcgctgggttccggcgtcatcattgat
gccgataaaggctatgtcgtcaccaacaaccacgttgttgataacgcgacggtcattaaa
gttcaactgagcgatggccgtaagttcgacgcgaagatggttggcaaagatccgcgctct
gatatcgcgctgatccaaatccagaacccgaaaaacctgaccgcaattaagatggcggat
tctgatgcactgcgcgtgggtgattacaccgtagcgattggtaacccgtttggtctgggc
gagacggtaacttccgggattgtctctgcgctggggcgtagcggcctgaatgccgaaaac
tacgaaaacttcatccagaccgatgcagcgatcaaccgtggtaactccggtggtgcgctg
gttaacctgaacggcgaactgatcggtatcaacaccgcgatcctcgcaccggacggcggc
aacatcggtatcggttttgctatcccgagtaacatggtgaaaaacctgacctcgcagatg
gtggaatacggccaggtgaaacgcggtgagctgggtattatggggactgagctgaactcc
gaactggcgaaagcgatgaaagttgacgcccagcgcggtgctttcgtaagccaggttctg
cctaattcctccgctgcaaaagcgggcattaaagcgggtgatgtgatcacctcactgaac
ggtaagccgatcagcagctttgccgcactgcgtgctcaggtgggtactatgccggtaggc
agcaaactgaccctgggcttactgcgcgacggtaagcaggttaacgtgaacctggaactg
cagcagagcagccagaatcaggttgattccagctccatcttcaacggcattgaaggcgct
gagatgagcaacaaaggcaaagatcagggcgtggtagtgaacaacgtgaaaacgggcact
ccggctgcgcagatcggcctgaagaaaggtgatgtgattattggcgcgaaccagcaggca
gtgaaaaacatcgctgaactgcgtaaagttctcgacagcaaaccgtctgtgctggcactc
aacattcagcgcggcgacagcaccatctacctgttaatgcagtaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 474 |
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| Protein Molecular Weight: | 49353 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 1KY9 |
| Signaling Regions: | |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Periplasmic serine endoprotease DegP
MKKTTLALSALALSLGLALSPLSATAAETSSATTAQQMPSLAPMLEKVMPSVVSINVEGS
TTVNTPRMPRNFQQFFGDDSPFCQEGSPFQSSPFCQGGQGGNGGGQQQKFMALGSGVIID
ADKGYVVTNNHVVDNATVIKVQLSDGRKFDAKMVGKDPRSDIALIQIQNPKNLTAIKMAD
SDALRVGDYTVAIGNPFGLGETVTSGIVSALGRSGLNAENYENFIQTDAAINRGNSGGAL
VNLNGELIGINTAILAPDGGNIGIGFAIPSNMVKNLTSQMVEYGQVKRGELGIMGTELNS
ELAKAMKVDAQRGAFVSQVLPNSSAAKAGIKAGDVITSLNGKPISSFAALRAQVGTMPVG
SKLTLGLLRDGKQVNVNLELQQSSQNQVDSSSIFNGIEGAEMSNKGKDQGVVVNNVKTGT
PAAQIGLKKGDVIIGANQQAVKNIAELRKVLDSKPSVLALNIQRGDSTIYLLMQ |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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