Identification
Name:Flagellar regulator flk
Synonyms:Not Available
Gene Name:flk
Enzyme Class:Not Available
Biological Properties
General Function:regulation of gene expression
Specific Function:Acts as a regulator of flagellar gene expression by modulating the protein level of the anti sigma factor FlgM upon sensing ring completion or hook elongation. Flk could inhibit FlgM secretion by acting as a braking system for the flagellar-associated type III secretion (T3S) system. Plays a role in hindering to flip the flagellar T3S specificity switch from the rod and hook-type substrates to filament-type substrates prior to hook-basal body (HBB) completion possibly by preventing interaction of FliK with FlhB (By similarity).
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
integral component of membrane
plasma membrane
regulation of gene expression
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>996
atgatacaacctatttccggccctcctcctgggcaaccaccaggtcagggagataatctg
ccgtctggcacgggcaatcagcctttatccagtcagcaacgtacttcgctggaaagctta
atgacgaaagtgacctcactgacgcaacagcaaagagcagaactgtgggcgggtatcagg
cacgatattggtctgtcgggagattcaccgctgctttcgcgtcacttccctgccgctgag
cataatctggcgcaacgtctgctggccgcgcaaaaaagccattctgcccgccagctttta
gcgcaattaggggagtatttacgtctggggaataatcgtcaggcggtcacggattatatc
cgtcataactttggtcagacgccgctgaatcagctctcaccggagcaattaaaaaccatt
ctcaccctgttgcaggaagggaagatggttattccgcaaccacagcagcgcgaggcgacc
gaccgtcctttattaccggcggagcacaatgcgctaaaacagctggtgaccaaacttgcg
gcggcaacgggggaacccagcaaacagatctggcaatcgatgctggaactttccggggtg
aaagatggcgagttaattccagcgaaactgtttaaccatctggtgacctggctacaggcg
cgtcagacgctaagccagcaaaatacgccgacgctggaatcactacagatgacgctaaaa
caacctttagatgccagtgaactggcggcgttatcggcatatatccagcaaaaatatggt
ctttctgcgcaatcatcgctttcttctgcccaggccgaggatattcttaatcagctttat
caacggcgggttaaagggattgatccgcgtgttatgcaaccgctgcttaatccttttcca
ccgatgatggacacgttgcaaaatatggcaacgcgtcccgcgctgtggatactgttagtc
gcgattatcctgatgctggtctggctggttcgttaa
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:331
Protein Molecular Weight:36667
Protein Theoretical pI:Not Available
Signaling Regions:Not Available
Transmembrane Regions:
  • 310-330
Protein Sequence:
>Flagellar regulator flk
MIQPISGPPPGQPPGQGDNLPSGTGNQPLSSQQRTSLESLMTKVTSLTQQQRAELWAGIR
HDIGLSGDSPLLSRHFPAAEHNLAQRLLAAQKSHSARQLLAQLGEYLRLGNNRQAVTDYI
RHNFGQTPLNQLSPEQLKTILTLLQEGKMVIPQPQQREATDRPLLPAEHNALKQLVTKLA
AATGEPSKQIWQSMLELSGVKDGELIPAKLFNHLVTWLQARQTLSQQNTPTLESLQMTLK
QPLDASELAALSAYIQQKYGLSAQSSLSSAQAEDILNQLYQRRVKGIDPRVMQPLLNPFP
PMMDTLQNMATRPALWILLVAIILMLVWLVR
References
External Links:
ResourceLink
Uniprot ID:P15286
Uniprot Name:FLK_ECOLI
CCDB:FLK_ECOLI
General Reference:Not Available