| Identification |
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| Name: | Acetate operon repressor |
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| Synonyms: | Not Available |
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| Gene Name: | iclR |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | transcription, DNA-templated |
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| Specific Function: | Regulation of the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase as well as isocitrate dehydrogenase kinase/phosphorylase. Glyoxylate disrupts the interaction with the promoter by favoring the inactive dimeric form. Pyruvate enhances promoter binding by stabilizing the tetrameric form. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| DNA binding | | glyoxylate cycle | | negative regulation of transcription, DNA-templated | | protein-DNA complex | | regulation of transcription, DNA-templated | | sequence-specific DNA binding transcription factor activity | | transcription, DNA-templated |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >825
atggtcgcacccattcccgcgaaacgcggcagaaaacccgccgttgccaccgcaccagcg
actggacaggttcagtctttaacgcgtggcctgaaattactggagtggattgccgaatcc
aatggcagtgtggcactcacggaactggcgcaacaagccgggttacccaattccacgacc
caccgcctgctaaccacgatgcaacagcagggtttcgtgcgtcaggttggcgaactggga
cattgggcaatcggcgcacatgcctttatggtcggcagcagctttctccagagccgtaat
ttgttagcgattgttcaccctatcctgcgcaatctaatggaagagtctggcgaaacggtc
aatatggcggtgcttgatcaaagcgatcacgaagcgattattatcgaccaggtacagtgt
acgcatctgatgcgaatgtccgcgcctatcggcggtaaattgccgatgcacgcttccggt
gcgggtaaagcctttttagcccaactgagcgaagaacaggtgacgaagctgctgcaccgc
aaagggttacatgcctatacccacgcaacgctggtgtctcctgtgcatttaaaagaagat
ctcgcccaaacgcgcaaacggggttattcatttgacgatgaggaacatgcactggggcta
cgttgccttgcagcgtgtattttcgatgagcaccgtgaaccgtttgccgcaatttctatt
tccggaccgatttcacgtattaccgatgaccgcgtgaccgagtttggcgcgatggtgatt
aaagcggcgaaggaagtgacgctggcgtacggtggaatgcgctga |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 274 |
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| Protein Molecular Weight: | 29739 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 1TD5 |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Acetate operon repressor
MVAPIPAKRGRKPAVATAPATGQVQSLTRGLKLLEWIAESNGSVALTELAQQAGLPNSTT
HRLLTTMQQQGFVRQVGELGHWAIGAHAFMVGSSFLQSRNLLAIVHPILRNLMEESGETV
NMAVLDQSDHEAIIIDQVQCTHLMRMSAPIGGKLPMHASGAGKAFLAQLSEEQVTKLLHR
KGLHAYTHATLVSPVHLKEDLAQTRKRGYSFDDEEHALGLRCLAACIFDEHREPFAAISI
SGPISRITDDRVTEFGAMVIKAAKEVTLAYGGMR |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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