| Identification |
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| Name: | Ribonuclease E |
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| Synonyms: | Not Available |
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| Gene Name: | rne |
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| Enzyme Class: | |
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| Biological Properties |
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| General Function: | tRNA processing |
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| Specific Function: | Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Can also process other RNA species, such as RNAI, a molecule that controls the replication of ColE1 plasmid, and the cell division inhibitor DicF-RNA. It initiates the decay of RNAs by cutting them internally near their 5'-end. It is able to remove poly(A) tails by an endonucleolytic process. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | |
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| Metabolites: | |
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| GO Classification: | | Function |
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| cytoplasm | | cytoplasmic side of plasma membrane | | endoribonuclease activity | | magnesium ion binding | | mRNA catabolic process | | ribonuclease activity | | ribonuclease E activity | | RNA binding | | RNA catabolic process | | RNA phosphodiester bond hydrolysis | | rRNA 5'-end processing | | tRNA processing | | zinc ion binding |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >3186
atgaaaagaatgttaatcaacgcaactcagcaggaagagttgcgcgttgcccttgtagat
gggcagcgtctgtatgacctggatatcgaaagtccagggcacgagcagaaaaaggcaaac
atctacaaaggtaaaatcacccgcattgaaccgagtctggaagctgcttttgttgattac
ggcgctgaacgtcacggtttcctcccactaaaagaaattgcccgcgaatatttccctgct
aactacagtgctcatggtcgtcccaacattaaagatgtgttgcgtgaaggtcaggaagtc
attgttcagatcgataaagaagagcgcggcaacaaaggcgcggcattaaccacctttatc
agtctggcgggtagctatctggttctgatgccgaacaacccgcgcgcgggtggcatttct
cgccgtatcgaaggcgacgaccgtaccgaattaaaagaagcactggcaagccttgaactg
ccggaaggcatggggcttatcgtgcgcaccgctggcgtcggcaaatctgctgaggcgctg
caatgggatttaagcttccgtctgaaacactgggaagccatcaaaaaagccgctgaaagc
cgcccggccccgttcctgattcatcaggagagcaacgtaatcgttcgcgcattccgcgat
tacttacgtcaggacatcggcgaaatccttatcgataacccgaaagtgctcgaactggca
cgtcagcatatcgctgcattaggtcgcccggatttcagcagcaaaatcaaactgtacacc
ggcgagatcccgctgttcagccactaccagatcgagtcacagatcgagtccgccttccag
cgtgaagttcgtctgccgtctggtggttccattgttatcgacagcaccgaagcgttaacg
gccatcgacatcaactccgcacgcgcgacccgcggcggcgatatcgaagaaaccgcgttt
aacactaacctcgaagctgccgatgagattgctcgtcagctgcgcctgcgtgacctcggc
ggcctgattgttatcgacttcatcgacatgacgccagtacgccaccagcgtgcggtagaa
aaccgtctgcgtgaagcggtgcgtcaggaccgtgcgcgtattcaaatcagccatatttct
cgctttggcctgctggaaatgtcccgtcagcgcctgagcccatcactgggtgaatccagt
catcacgtttgtccgcgttgttctggtactggcaccgtgcgtgacaacgaatcgctgtcg
ctctctattctgcgtctgatcgaagaagaagcgctgaaagagaacacccaggaagttcac
gccattgttcctgtgccaatcgcttcttacctgctgaatgaaaaacgttctgcggtaaat
gccattgaaactcgtcaggacggtgtgcgctgtgtaattgtgccaaacgatcagatggaa
accccgcactaccacgtgctgcgcgtgcgtaaaggggaagaaaccccaaccttaagctac
atgctgccgaagctgcatgaagaagcgatggcgctgccgtctgaagaagagttcgctgaa
cgtaagcgtccggaacaacctgcgctggcaacctttgccatgccggatgtgccgcctgcg
ccaacgccagctgaacctgccgcgcctgttgtagctccagcaccgaaagctgcaccggca
acaccagcagctcctgcacaacctgggctgttgagccgcttcttcggcgcactgaaagcg
ctgttcagcggtggtgaagaaaccaaaccgaccgagcaaccagcaccgaaagcagaagcg
aaaccggaacgtcaacaggatcgtcgcaagcctcgtcagaacaaccgccgtgaccgtaat
gagcgccgcgacacccgtagtgaacgtactgaaggcagcgataatcgcgaagaaaaccgt
cgtaatcgtcgccaggcacagcagcagactgccgagacgcgtgagagccgtcagcaggct
gaggtaacggaaaaagcgcgtaccgccgacgagcagcaagcgccgcgtcgtgaacgtagc
cgccgccgtaatgatgataaacgtcaggcgcaacaagaagcgaaggcgctgaatgttgaa
gagcaatctgttcaggaaaccgaacaggaagaacgtgtacgtccggttcagccgcgtcgt
aaacagcgtcagctcaatcagaaagtgcgttacgagcaaagcgtagccgaagaagcggta
gtcgcaccggtggttgaagaaactgtcgctgccgaaccaattgttcaggaagcgccagct
ccacgcacagaactggtgaaagtcccgctgccagtcgtagcgcaaactgcaccagaacag
caagaagagaacaatgctgataaccgtgacaacggtggcatgccgcgtcgttctcgccgc
tcgcctcgtcacctgcgcgtaagtggtcagcgtcgtcgtcgctatcgtgacgagcgttat
ccaacccagtcgccaatgccgttgaccgtagcgtgcgcgtctccggaactggcctctggc
aaagtctggatccgctatccaattgtacgtccgcaagatgtacaggttgaagagcagcgc
gaacaggaagaagtacatgtgcagccgatggtgactgaggtccctgtcgccgccgctatc
gaaccggttgttagcgcgccagttgttgaagaagtggccggtgtcgtagaagcccccgtt
caggttgccgaaccgcaaccggaagtggttgaaacgacgcatcctgaagtgatcgctgcc
gcggtaactgaacagccgcaggtgattaccgagtctgatgttgccgtagcccaggaagtt
gcagaacaagcagaaccggtggttgaaccgcaggaagagacggcagatattgaagaagtt
gtcgaaactgctgaggttgtagttgctgaacctgaagttgttgctcaacctgccgcgcca
gtagtcgctgaagtcgcagcagaagttgaaacggtagctgcggtcgaacctgaggtcacc
gttgagcataaccacgctaccgcgccaatgacgcgcgctccagcaccggaatatgttccg
gaggcaccgcgtcacagtgactggcagcgccctacttttgccttcgaaggtaaaggtgcc
gcaggtggtcatacggcaacacatcatgcctctgccgctcctgcgcgtccgcaacctgtt
gagtaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 1061 |
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| Protein Molecular Weight: | 118195 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 1SLJ |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Ribonuclease E
MKRMLINATQQEELRVALVDGQRLYDLDIESPGHEQKKANIYKGKITRIEPSLEAAFVDY
GAERHGFLPLKEIAREYFPANYSAHGRPNIKDVLREGQEVIVQIDKEERGNKGAALTTFI
SLAGSYLVLMPNNPRAGGISRRIEGDDRTELKEALASLELPEGMGLIVRTAGVGKSAEAL
QWDLSFRLKHWEAIKKAAESRPAPFLIHQESNVIVRAFRDYLRQDIGEILIDNPKVLELA
RQHIAALGRPDFSSKIKLYTGEIPLFSHYQIESQIESAFQREVRLPSGGSIVIDSTEALT
AIDINSARATRGGDIEETAFNTNLEAADEIARQLRLRDLGGLIVIDFIDMTPVRHQRAVE
NRLREAVRQDRARIQISHISRFGLLEMSRQRLSPSLGESSHHVCPRCSGTGTVRDNESLS
LSILRLIEEEALKENTQEVHAIVPVPIASYLLNEKRSAVNAIETRQDGVRCVIVPNDQME
TPHYHVLRVRKGEETPTLSYMLPKLHEEAMALPSEEEFAERKRPEQPALATFAMPDVPPA
PTPAEPAAPVVAPAPKAAPATPAAPAQPGLLSRFFGALKALFSGGEETKPTEQPAPKAEA
KPERQQDRRKPRQNNRRDRNERRDTRSERTEGSDNREENRRNRRQAQQQTAETRESRQQA
EVTEKARTADEQQAPRRERSRRRNDDKRQAQQEAKALNVEEQSVQETEQEERVRPVQPRR
KQRQLNQKVRYEQSVAEEAVVAPVVEETVAAEPIVQEAPAPRTELVKVPLPVVAQTAPEQ
QEENNADNRDNGGMPRRSRRSPRHLRVSGQRRRRYRDERYPTQSPMPLTVACASPELASG
KVWIRYPIVRPQDVQVEEQREQEEVHVQPMVTEVPVAAAIEPVVSAPVVEEVAGVVEAPV
QVAEPQPEVVETTHPEVIAAAVTEQPQVITESDVAVAQEVAEQAEPVVEPQEETADIEEV
VETAEVVVAEPEVVAQPAAPVVAEVAAEVETVAAVEPEVTVEHNHATAPMTRAPAPEYVP
EAPRHSDWQRPTFAFEGKGAAGGHTATHHASAAPARPQPVE |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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