| Identification |
|---|
| Name: | Chromosome partition protein MukB |
|---|
| Synonyms: | Not Available |
|---|
| Gene Name: | mukB |
|---|
| Enzyme Class: | Not Available |
|---|
| Biological Properties |
|---|
| General Function: | sister chromatid cohesion |
|---|
| Specific Function: | Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organizes and compacts chromosomes. May achieve or facilitate chromosome segregation by condensation of DNA from both sides of a centrally located replisome during cell division. Stimulates both DNA relaxation and to a lesser extent decatenation activity of topoisomerase IV. |
|---|
| Cellular Location: | Not Available |
|---|
| SMPDB Pathways: | Not Available |
|---|
| KEGG Pathways: | Not Available |
|---|
| Metabolites: | |
|---|
| GO Classification: | | Function |
|---|
| ATP binding | | cell division | | chromosome condensation | | chromosome segregation | | condensin complex | | cytoplasm | | DNA binding | | DNA replication | | GTP binding | | identical protein binding | | nucleoid | | sister chromatid cohesion |
|
|---|
| Gene Properties |
|---|
| Blattner: | Not Available |
|---|
| Gene Orientation | Not Available |
|---|
| Centisome Percentage: | Not Available |
|---|
| Left Sequence End | Not Available |
|---|
| Right Sequence End | Not Available |
|---|
| Gene Sequence: | >4461
atgattgaacgcggtaaatttcgctcactgacgctgattaactggaacggcttttttgcc
cgaacttttgaccttgacgagctggtcacgacgctttctggcggtaacggggcgggtaaa
tccaccaccatggcggcgttcgttacggcgctgatccccgacctgaccctgctgcatttc
cgtaacactacggaagccggggccaccagcggttcgcgcgataaaggtctgcacggtaag
ctgaaagcgggtgtctgttattcgatgctcgacaccattaactcgcgccaccagcgcgtg
gtggtcggtgtgcgtctgcaacaggttgccggacgcgatcgtaaagtggatatcaagccg
tttgccattcagggactgccgatgtcggtgcagccgacacagctggtgaccgaaaccctg
aacgaacgccaggcgcgcgtgctgccgcttaacgagctgaaagacaagctcgaggcgatg
gaaggcgtgcagtttaaacagttcaactccattactgattaccactcgctgatgttcgat
ctgggcatcatcgcgcgtcgtctgcgctccgcatctgaccgtagcaaattctatcgtctg
atcgaagcttcgctgtatggcgggatctccagtgccattacccgttctctgcgcgactac
ctgttgccagaaaacagcggcgtgcgtaaagcgttccaggacatggaagcggcgctgcgt
gaaaaccgtatgacgctggaagcgattcgtgtcacccagtcggaccgcgacctgtttaag
catctgatcagcgaagccaccaactacgtggcggcggactacatgcgtcacgccaacgag
cgccgtgtccatctcgacaaagccctggagtttcgtcgcgagctacatacttcgcgtcag
caactggcggctgagcagtacaaacacgtcgatatggcgcgtgagctggcagagcacaac
ggtgccgaaggcgatctggaagcggattatcaggcggccagtgatcacctgaacctggtg
caaaccgcactgcgtcagcaggagaagatcgaacgctacgaagcggatctcgatgagctg
cagatccgtctggaagagcaaaatgaagtggtggcagaagccatcgaacgccagcaagag
aatgaggctcgtgcggaagctgccgaactggaagtggacgagctgaaaagccagcttgct
gactaccagcaggcgctggacgtccagcaaacgcgcgcgatccagtataaccaggcgatt
gctgcgcttaatcgtgccaaagaactgtgccatctgccggacttaaccgccgactgcgcc
gccgaatggctggaaaccttccaggcgaaagagctggaagcgactgaaaaaatgctctct
cttgagcagaaaatgagcatggcgcaaaccgcgcacagccagtttgagcaggcttatcag
ctggtggtggcaatcaacggcccactggcgcgtaacgaggcgtgggatgtcgctcgcgaa
ctattgcgcgaaggggtcgatcagcgtcacctggcagagcaggttcagccgctgcggatg
cgattaagcgaactggaacagcgtctacgcgagcagcaagaagctgagcgtctgctggca
gatttctgcaaacgtcagggcaagaattttgatatcgacgaactggaagccctgcatcag
gaactggaagcacgcattgcctctctttccgatagcgtgtctaacgcccgtgaagagcgc
atggcactgcgccaggagcaggaacagctgcagtctcgcattcagagtttgatgcagcgt
gcgccggtttggctggcagcgcaaaacagtctcaaccagttgagcgaacagtgcggcgaa
gagtttacctccagccaggacgtcaccgaatatctgcaacagttgctggagcgtgagcga
gaggcgattgttgaacgcgatgaagtgggcgcgcgcaaaaacgccgtcgatgaagagatc
gaacgtttaagccagcctggcggctctgaagatcagcgtctgaacgcgctggcggagcgt
tttggtggtgtgctgctgtcagaaatttatgacgacgttagcctggaagatgcgccgtac
ttctcagcgctgtatggcccgtcacgccacgccatcgtggtgccagatctgtcacaggta
actgaacacctggaaggcttgaccgattgcccggaagatctctatctgatcgaaggagat
ccgcagtcattcgatgacagcgtgttcagcgttgatgagctggaaaaagcggtagtggtg
aaaatcgccgatcgtcagtggcgttattcacgtttcccggaagtgccgctgtttggtcgt
gctgcgcgtgaaagccgtattgaaagcctccatgccgagcgtgaagtgctttccgaacgc
ttcgccacgctctcctttgatgtacagaaaactcagcgtctgcatcaggcgttcagccgc
tttatcggcagtcatctggcggttgcgtttgagtctgacccggaagcagaaatccgtcaa
ctgaacagccgtcgcgtcgaactggagcgggcgttaagtaatcatgaaaatgataaccag
cagcagcgtattcagtttgagcaggcgaaagagggcgttacggcgctgaaccgcattctg
ccgcgtctcaacctgttggctgatgacagcctggcggatcgcgtcgatgaaatccgcgaa
cgtctggatgaagcccaggaagccgcgcgttttgttcagcagtttggcaatcaactggcg
aaactggaaccgattgtttcggtattgcagagcgacccggaacagttcgaacagttaaaa
gaagattacgcgtactctcagcagatgcagcgcgatgcccgtcagcaggcgtttgccctg
acggaagtggtgcagcgtcgtgcgcactttagctattctgactcggcagaaatgcttagc
ggtaacagcgatctcaacgaaaaactgcgtgaacgtctggaacaggcggaagcggagcgt
acccgcgctcgcgaagcgttgcgcggtcacgcagcgcagttgagtcagtacaaccaggtg
ctggcttcgctgaaaagttcttacgacaccaaaaaagagctactcaacgatctgcaacgt
gaattgcaggatatcggcgtgcgtgctgatagcggggcagaagagcgggcgcgtattcgc
cgtgacgagctgcatgcgcaactgagcaataaccgttcacgccgcaatcaactggaaaaa
gcgcttaccttctgcgaagcggagatggacaacctgacccgcaaactgcgcaagctggag
cgggattactttgagatgcgcgagcaggtagtgaccgccaaagcgggctggtgtgcggtg
atgcgcatggtgaaagataacggcgttgagcgccgcttacaccgtcgtgagctggcttat
ctctccgctgatgatttgcgttccatgtcggataaggcgttaggtgcgctgcgtctggcg
gtggcggataacgaacatctgcgcgacgtgctgcgcatgtcggaagatccgaaacgtccg
gagcgtaaaattcagttcttcgtggcggtttatcagcatctgcgtgaacgtattcgtcag
gatattattcgtaccgatgatccggtggaagctatcgaacagatggagattgaacttagc
cgtctgaccgaagaattaacctcccgtgaacagaaactggcgatcagttcccgcagcgtg
gcgaacatcattcgcaaaaccattcagcgcgagcagaaccgtatccgtatgctcaaccag
gggttgcagaacgtatcgtttggtcaggtgaacagcgtgcgtctcaacgtgaacgtgcgt
gaaacgcacgccatgctactggatgtgctctctgaacagcacgagcagcatcaggatctg
tttaacagcaaccgtttgaccttctcggaagcgctggcgaaactgtatcaacgtcttaac
ccgcagattgatatggggcagcgcacgccgcagaccatcggtgaagaactgctggattac
cgcaactatctggaaatggaagttgaggttaaccgtggttccgatggctggctgcgcgca
gagtctggtgcattgtcgaccggtgaggcgattggtaccggtatgtcgattctggtgatg
gtggtacaaagctgggaagatgaatctcgccgcctgcgcggtaaagatatctctccttgc
cgcctgctgttcctcgatgaagcagcgcgactggatgctcgttctatcgccacgctgttt
gaattgtgtgagcgtttgcaaatgcaactcatcatcgcagcgccggaaaatatcagcccg
gagaaaggcaccacctataaactggtgcgtaaagtcttccagaataccgaacacgttcat
gtcgtcggcctgcgaggatttgcgccgcaactccctgaaacgcttccaggaactgacgaa
gcgccttctcaggcgagttaa |
|---|
| Protein Properties |
|---|
| Pfam Domain Function: | Not Available |
|---|
| Protein Residues: | 1486 |
|---|
| Protein Molecular Weight: | 170228 |
|---|
| Protein Theoretical pI: | Not Available |
|---|
| PDB File: | 1QHL |
| Signaling Regions: | Not Available |
|---|
| Transmembrane Regions: | Not Available |
|---|
| Protein Sequence: | >Chromosome partition protein MukB
MIERGKFRSLTLINWNGFFARTFDLDELVTTLSGGNGAGKSTTMAAFVTALIPDLTLLHF
RNTTEAGATSGSRDKGLHGKLKAGVCYSMLDTINSRHQRVVVGVRLQQVAGRDRKVDIKP
FAIQGLPMSVQPTQLVTETLNERQARVLPLNELKDKLEAMEGVQFKQFNSITDYHSLMFD
LGIIARRLRSASDRSKFYRLIEASLYGGISSAITRSLRDYLLPENSGVRKAFQDMEAALR
ENRMTLEAIRVTQSDRDLFKHLISEATNYVAADYMRHANERRVHLDKALEFRRELHTSRQ
QLAAEQYKHVDMARELAEHNGAEGDLEADYQAASDHLNLVQTALRQQEKIERYEADLDEL
QIRLEEQNEVVAEAIERQQENEARAEAAELEVDELKSQLADYQQALDVQQTRAIQYNQAI
AALNRAKELCHLPDLTADCAAEWLETFQAKELEATEKMLSLEQKMSMAQTAHSQFEQAYQ
LVVAINGPLARNEAWDVARELLREGVDQRHLAEQVQPLRMRLSELEQRLREQQEAERLLA
DFCKRQGKNFDIDELEALHQELEARIASLSDSVSNAREERMALRQEQEQLQSRIQSLMQR
APVWLAAQNSLNQLSEQCGEEFTSSQDVTEYLQQLLEREREAIVERDEVGARKNAVDEEI
ERLSQPGGSEDQRLNALAERFGGVLLSEIYDDVSLEDAPYFSALYGPSRHAIVVPDLSQV
TEHLEGLTDCPEDLYLIEGDPQSFDDSVFSVDELEKAVVVKIADRQWRYSRFPEVPLFGR
AARESRIESLHAEREVLSERFATLSFDVQKTQRLHQAFSRFIGSHLAVAFESDPEAEIRQ
LNSRRVELERALSNHENDNQQQRIQFEQAKEGVTALNRILPRLNLLADDSLADRVDEIRE
RLDEAQEAARFVQQFGNQLAKLEPIVSVLQSDPEQFEQLKEDYAYSQQMQRDARQQAFAL
TEVVQRRAHFSYSDSAEMLSGNSDLNEKLRERLEQAEAERTRAREALRGHAAQLSQYNQV
LASLKSSYDTKKELLNDLQRELQDIGVRADSGAEERARIRRDELHAQLSNNRSRRNQLEK
ALTFCEAEMDNLTRKLRKLERDYFEMREQVVTAKAGWCAVMRMVKDNGVERRLHRRELAY
LSADDLRSMSDKALGALRLAVADNEHLRDVLRMSEDPKRPERKIQFFVAVYQHLRERIRQ
DIIRTDDPVEAIEQMEIELSRLTEELTSREQKLAISSRSVANIIRKTIQREQNRIRMLNQ
GLQNVSFGQVNSVRLNVNVRETHAMLLDVLSEQHEQHQDLFNSNRLTFSEALAKLYQRLN
PQIDMGQRTPQTIGEELLDYRNYLEMEVEVNRGSDGWLRAESGALSTGEAIGTGMSILVM
VVQSWEDESRRLRGKDISPCRLLFLDEAARLDARSIATLFELCERLQMQLIIAAPENISP
EKGTTYKLVRKVFQNTEHVHVVGLRGFAPQLPETLPGTDEAPSQAS |
|---|
| References |
|---|
| External Links: | |
|---|
| General Reference: | Not Available |
|---|
