| Identification |
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| Name: | Transcriptional regulatory protein PhoP |
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| Synonyms: | Not Available |
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| Gene Name: | phoP |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | transcription, DNA-templated |
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| Specific Function: | Member of the two-component regulatory system PhoP/PhoQ involved in adaptation to low Mg(2+) environments and the control of acid resistance genes. In low periplasmic Mg(2+), PhoQ phosphorylates PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2+), PhoQ dephosphorylates phospho-PhoP, resulting in the repression of PAG and may lead to expression of some PRG (By similarity). Mediates magnesium influx to the cytosol by activation of MgtA. Promotes expression of the two-component regulatory system rstA/rstB and transcription of the hemL, mgrB, nagA, slyB, vboR and yrbL genes. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | - Cationic antimicrobial peptide (CAMP) resistance eco01503
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| Metabolites: | |
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| GO Classification: | | Function |
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| cytoplasm | | DNA binding | | identical protein binding | | phosphorelay signal transduction system | | regulation of transcription, DNA-templated | | transcription, DNA-templated |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >672
atgcgcgtactggttgttgaagacaatgcgttgttacgtcaccaccttaaagttcagatt
caggatgctggtcatcaggtcgatgacgcagaagatgccaaagaagccgattattatctc
aatgaacatataccggatattgcgattgtcgatctcggattgccagacgaggacggtctg
tcactgattcgccgctggcgtagcaacgatgtttcactgccgattctggtattaaccgcc
cgtgaaagctggcaggacaaagtcgaagtattaagtgccggtgctgatgattatgtgact
aaaccgtttcatattgaagaggtgatggcgcgaatgcaggcattaatgcggcgtaatagc
ggtctggcttcacaggtcatttcgctccccccgtttcaggttgatctctctcgccgtgaa
ttatctattaatgacgaagtgatcaaactgaccgcgttcgaatacactattatggaaacg
ttgatacgcaataatggcaaagtggtcagcaaagattcgttaatgctccaactctatccg
gatgcggagctgcgggaaagccataccattgatgtactgatgggacgtctgcgcaaaaaa
attcaggcacaatatccccaagaagtgattaccaccgttcgcggccagggctatctgttc
gaattgcgctga |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 223 |
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| Protein Molecular Weight: | 25534 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 2PKX |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Transcriptional regulatory protein PhoP
MRVLVVEDNALLRHHLKVQIQDAGHQVDDAEDAKEADYYLNEHIPDIAIVDLGLPDEDGL
SLIRRWRSNDVSLPILVLTARESWQDKVEVLSAGADDYVTKPFHIEEVMARMQALMRRNS
GLASQVISLPPFQVDLSRRELSINDEVIKLTAFEYTIMETLIRNNGKVVSKDSLMLQLYP
DAELRESHTIDVLMGRLRKKIQAQYPQEVITTVRGQGYLFELR |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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