Identification
Name:Protease HtpX
Synonyms:Not Available
Gene Name:htpX
Enzyme Class:Not Available
Biological Properties
General Function:response to temperature stimulus
Specific Function:Membrane-localized protease able to endoproteolytically degrade overproduced SecY but not YccA, another membrane protein. It seems to cleave SecY at specific cytoplasmic sites. Does not require ATP. Its natural substrate has not been identified. Probably plays a role in the quality control of integral membrane proteins.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
integral component of membrane
metalloendopeptidase activity
plasma membrane
proteolysis
response to temperature stimulus
zinc ion binding
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>882
atgatgcgaatcgcgctcttcctgctaacgaacctggccgtaatggtcgttttcgggctg
gtactgagcctgacagggatacagtcgagcagcgttcaggggctgatgatcatggccttg
ctgttcggttttggtggttccttcgtttcgcttctgatgtccaaatggatggcattacga
tctgttggcggggaagtgatcgagcaaccgcgtaacgaaagggaacgttggctggtcaat
actgtagcaacccaggctcgtcaggcggggatcgctatgccgcaagtggctatctaccat
gcgccggacatcaacgcttttgcaaccggtgcgcgccgtgatgcctctctggttgctgtc
agcaccggtttgctgcagaacatgagcccggatgaagccgaggcggtaattgctcacgaa
atcagccacatcgccaatggtgatatggtcaccatgacgctgattcagggcgtggtgaac
accttcgttatctttatttcccgtattctggcgcagcttgccgcgggttttatgggcgga
aatcgtgatgaaggtgaagagagcaacggcaacccgctgatctactttgcggttgcaacg
gttctggaactggtgtttggtattctggcgagcattatcaccatgtggttctcgcgtcat
cgtgaattccatgctgatgccggttcggcaaaactggttggtcgcgagaaaatgattgcc
gcgctgcagcgcctgaaaaccagctatgaaccgcaagaagcaaccagcatgatggctctc
tgcattaacggtaagtcgaaatcgctcagtgagttgttcatgacccacccgccgctggat
aaacgaattgaagctctgcgtacgggtgaatacctgaagtaa
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:293
Protein Molecular Weight:31923
Protein Theoretical pI:Not Available
Signaling Regions:Not Available
Transmembrane Regions:
  • 4-24
  • 34-54
Protein Sequence:
>Protease HtpX
MMRIALFLLTNLAVMVVFGLVLSLTGIQSSSVQGLMIMALLFGFGGSFVSLLMSKWMALR
SVGGEVIEQPRNERERWLVNTVATQARQAGIAMPQVAIYHAPDINAFATGARRDASLVAV
STGLLQNMSPDEAEAVIAHEISHIANGDMVTMTLIQGVVNTFVIFISRILAQLAAGFMGG
NRDEGEESNGNPLIYFAVATVLELVFGILASIITMWFSRHREFHADAGSAKLVGREKMIA
ALQRLKTSYEPQEATSMMALCINGKSKSLSELFMTHPPLDKRIEALRTGEYLK
References
External Links:
ResourceLink
Uniprot ID:P23894
Uniprot Name:HTPX_ECOLI
CCDB:HTPX_ECOLI
General Reference:Not Available