| Identification |
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| Name: | RNA 2',3'-cyclic phosphodiesterase |
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| Synonyms: | Not Available |
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| Gene Name: | thpR |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | RNA metabolic process |
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| Specific Function: | Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester (PubMed:25239919). In vitro, can also ligate 5' and 3' half-tRNA molecules with 2',3'-cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. This reaction does not require ATP and is reversible (PubMed:6347395 and PubMed:8940112). |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| 2'-5'-RNA ligase activity | | phosphoric diester hydrolase activity | | RNA metabolic process |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >531
atgtctgaaccgcaacgtctgttctttgctatcgacttacctgcagaaatccgcgaacag
attatccattggcgcgccacacacttcccacctgaggcgggacgtccggtcgccgccgat
aatttgcatctgactctggcatttttaggcgaagtgagcgccgagaaagagaaggcgctt
tctcttttagccggacggattcgtcaacctggtttcacactcacgcttgatgacgccgga
caatggctgcgttcgcgtgtggtgtggttagggatgcgtcagccgccacgcggcttaatc
cagctggcgaatatgctccgttcacaggctgcccgcagcggttgttttcaaagcaatcgt
ccgtttcatccacatattaccttattgcgcgacgccagcgaggcggtgacaatcccgccg
ccaggttttaactggtcgtatgcggtgacggagttcaccctttacgcctcctcgtttgcc
cgtggacgcacacgctacacgccgctaaaacgctgggcgctaacgcaataa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 176 |
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| Protein Molecular Weight: | 19933 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 4QAK |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >RNA 2',3'-cyclic phosphodiesterase
MSEPQRLFFAIDLPAEIREQIIHWRATHFPPEAGRPVAADNLHLTLAFLGEVSAEKEKAL
SLLAGRIRQPGFTLTLDDAGQWLRSRVVWLGMRQPPRGLIQLANMLRSQAARSGCFQSNR
PFHPHITLLRDASEAVTIPPPGFNWSYAVTEFTLYASSFARGRTRYTPLKRWALTQ |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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