Identification |
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Name: | Isoaspartyl dipeptidase |
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Synonyms: | Not Available |
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Gene Name: | iadA |
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Enzyme Class: | Not Available |
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Biological Properties |
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General Function: | zinc ion binding |
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Specific Function: | Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. The best substrate for the enzyme reported thus far is iso-Asp-Leu. |
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Cellular Location: | Not Available |
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SMPDB Pathways: | Not Available |
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KEGG Pathways: | Not Available |
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Metabolites: | |
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GO Classification: | Function |
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beta-aspartyl-peptidase activity | cytoplasm | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | metallopeptidase activity | zinc ion binding |
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Gene Properties |
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Blattner: | Not Available |
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Gene Orientation | Not Available |
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Centisome Percentage: | Not Available |
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Left Sequence End | Not Available |
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Right Sequence End | Not Available |
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Gene Sequence: | >1173
atgattgattataccgcagccggttttaccctgctgcagggagcgcatttgtatgcgccg
gaagatcggggaatttgcgatgtcctcgtcgctaacggcaaaattatcgccgttgccagc
aatatcccttctgacattgtaccgaactgcacggttgtcgatctcagtgggcagatcctc
tgcccaggttttattgatcaacacgtccatttgattggcggtggcggcgaagcaggtccc
acgacgcgcacgccggaagtggcgctaagtcgcctgacggaagcgggcgtcacgtcagtg
gttggtctgctgggcaccgactctatctctcgccacccggaatccctgctcgccaagacc
cgtgcgctcaatgaagaaggcatcagcgcctggatgctgaccggcgcttatcatgtccct
tcccgcaccattacgggttccgtggaaaaagacgtggcgattatcgatcgtgtgattggc
gtgaaatgcgccatctctgatcaccgttctgccgcaccggacgtttatcacctggccaat
atggcggcagaatcccgcgttggcggtttgctcggcggtaaacctggcgtcaccgtgttc
cacatgggcgacagtaaaaaggcgttacagcctatttatgacctgctggaaaactgcgat
gtgccgatcagcaagctgctgccgacccacgttaaccgcaacgtaccgttgtttgagcag
gcgctggagttcgcgcgcaaaggcggcaccatcgatatcaccagcagcattgacgaaccg
gtcgcccctgccgaaggtattgcccgcgccgttcaggcgggtattccgctggcacgcgtc
accctcagctccgacggcaacggtagccagccgttcttcgatgacgaagggaatttaacc
catatcggtgttgccggttttgaaacgttgctggaaaccgtgcaggtgctggtcaaagac
tatgatttcagtatcagcgatgccctgcgcccgctcaccagtagcgtagccggtttcctt
aacctgaccgggaaaggcgaaattctgccaggcaatgatgctgacttgctggtcatgacg
ccagaactgcgcattgagcaggtatacgctcgcggcaaactgatggtcaaagacggcaaa
gcctgcgtgaaaggaacgtttgaaacggcttaa |
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Protein Properties |
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Pfam Domain Function: | Not Available |
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Protein Residues: | 390 |
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Protein Molecular Weight: | 41083 |
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Protein Theoretical pI: | Not Available |
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PDB File: | 1ONW |
Signaling Regions: | Not Available |
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Transmembrane Regions: | Not Available |
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Protein Sequence: | >Isoaspartyl dipeptidase
MIDYTAAGFTLLQGAHLYAPEDRGICDVLVANGKIIAVASNIPSDIVPNCTVVDLSGQIL
CPGFIDQHVHLIGGGGEAGPTTRTPEVALSRLTEAGVTSVVGLLGTDSISRHPESLLAKT
RALNEEGISAWMLTGAYHVPSRTITGSVEKDVAIIDRVIGVKCAISDHRSAAPDVYHLAN
MAAESRVGGLLGGKPGVTVFHMGDSKKALQPIYDLLENCDVPISKLLPTHVNRNVPLFEQ
ALEFARKGGTIDITSSIDEPVAPAEGIARAVQAGIPLARVTLSSDGNGSQPFFDDEGNLT
HIGVAGFETLLETVQVLVKDYDFSISDALRPLTSSVAGFLNLTGKGEILPGNDADLLVMT
PELRIEQVYARGKLMVKDGKACVKGTFETA |
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References |
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External Links: | |
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General Reference: | Not Available |
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