Identification
Name:FKBP-type peptidyl-prolyl cis-trans isomerase fkpA
Synonyms:
  • PPIase
  • Rotamase
Gene Name:fkpA
Enzyme Class:
Biological Properties
General Function:Posttranslational modification, protein turnover, chaperones
Specific Function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Cellular Location:Periplasm
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
KEGG Reactions:
1.0Peptidylproline (omega=180)1.0Peptidylproline (omega=0)
1.0Peptidylproline (omega=180) ↔ 1.0Peptidylproline (omega=0)
ReactionCard
Metabolites:
ECMDB IDNameView
GO Classification:
Process
cellular protein metabolic process
macromolecule metabolic process
metabolic process
protein folding
protein metabolic process
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>813 bp
ATGAAATCACTGTTTAAAGTAACGCTGCTGGCGACCACAATGGCCGTTGCCCTGCATGCA
CCAATCACTTTTGCTGCTGAAGCTGCAAAACCTGCTACAGCTGCTGACAGCAAAGCAGCG
TTCAAAAATGACGATCAGAAATCAGCTTATGCACTGGGTGCCTCGCTGGGTCGTTACATG
GAAAACTCTCTAAAAGAACAAGAAAAACTGGGCATCAAACTGGATAAAGATCAGCTGATC
GCTGGTGTTCAGGATGCATTTGCTGATAAGAGCAAACTCTCCGACCAAGAGATCGAACAG
ACTCTACAAGCATTCGAAGCTCGCGTGAAGTCTTCTGCTCAGGCGAAGATGGAAAAAGAC
GCGGCTGATAACGAAGCAAAAGGTAAAGAGTACCGCGAGAAATTTGCCAAAGAGAAAGGT
GTGAAAACCTCTTCAACTGGTCTGGTTTATCAGGTAGTAGAAGCCGGTAAAGGCGAAGCA
CCGAAAGACAGCGATACTGTTGTAGTGAACTACAAAGGTACGCTGATCGACGGTAAAGAG
TTCGACAACTCTTACACCCGTGGTGAACCGCTTTCTTTCCGTCTGGACGGTGTTATCCCG
GGTTGGACAGAAGGTCTGAAGAACATCAAGAAAGGCGGTAAGATCAAACTGGTTATTCCA
CCAGAACTGGCTTACGGCAAAGCGGGTGTTCCGGGGATCCCACCGAATTCTACCCTGGTG
TTTGACGTAGAGCTGCTGGATGTGAAACCAGCGCCGAAGGCTGATGCAAAGCCGGAAGCT
GATGCGAAAGCCGCAGATTCTGCTAAAAAATAA
Protein Properties
Pfam Domain Function:
Protein Residues:270
Protein Molecular Weight:28882
Protein Theoretical pI:9
PDB File:1Q6U
Signaling Regions:
  • 1-25
Transmembrane Regions:
  • None
Protein Sequence:
>FKBP-type peptidyl-prolyl cis-trans isomerase fkpA
MKSLFKVTLLATTMAVALHAPITFAAEAAKPATAADSKAAFKNDDQKSAYALGASLGRYM
ENSLKEQEKLGIKLDKDQLIAGVQDAFADKSKLSDQEIEQTLQAFEARVKSSAQAKMEKD
AADNEAKGKEYREKFAKEKGVKTSSTGLVYQVVEAGKGEAPKDSDTVVVNYKGTLIDGKE
FDNSYTRGEPLSFRLDGVIPGWTEGLKNIKKGGKIKLVIPPELAYGKAGVPGIPPNSTLV
FDVELLDVKPAPKADAKPEADAKAADSAKK
References
External Links:
ResourceLink
Uniprot ID:P45523
Uniprot Name:FKBA_ECOLI
GenBank Gene ID:L28082
Genebank Protein ID:862300
PDB ID:1Q6U
CCDB:FKBA_ECOLI
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Horne, S. M., Young, K. D. (1995). "Escherichia coli and other species of the Enterobacteriaceae encode a protein similar to the family of Mip-like FK506-binding proteins." Arch Microbiol 163:357-365. Pubmed: 7540828
  • Link, A. J., Robison, K., Church, G. M. (1997). "Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12." Electrophoresis 18:1259-1313. Pubmed: 9298646
  • Missiakas, D., Betton, J. M., Raina, S. (1996). "New components of protein folding in extracytoplasmic compartments of Escherichia coli SurA, FkpA and Skp/OmpH." Mol Microbiol 21:871-884. Pubmed: 8878048