| Identification |
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| Name: | DNA translocase FtsK |
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| Synonyms: | Not Available |
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| Gene Name: | ftsK |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | response to salt stress |
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| Specific Function: | Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif. Stoppage of translocation is accompanied by a reduction in ATPase activity. Also stimulates topoisomerase 4 activity. Required for the targeting of FtsQ, FtsL and FtsI to the septum. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| ATP binding | | ATPase activity | | cell cycle | | cell division | | cell separation after cytokinesis | | cellular response to antibiotic | | chromosome segregation | | DNA binding | | DNA translocase activity | | double-stranded DNA-dependent ATPase activity | | identical protein binding | | integral component of plasma membrane | | membrane | | metabolic process | | plasma membrane | | positive regulation of catalytic activity | | positive regulation of transcription, DNA-templated | | response to osmotic stress | | response to salt stress | | sequence-specific DNA binding |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >3990
ttgagccaggaatacattgaagacaaagaagtcacattgacaaagttaagtagcggccgc
cgccttctggaggcgttgctgatccttattgtcctgtttgccgtctggttgatggctgcc
ttactaagctttaacccttcggaccccagctggtcgcaaacggcctggcatgaacctatc
cataatttaggtgggatgcccggtgcgtggttggcagatacgctgttctttatttttggc
gtgatggcttacaccattcccgtcattattgtcggcggttgttggtttgcctggcgtcat
cagtccagcgacgaatacattgattattttgccgtttcgctacgcatcattggcgttttg
gcgctcatccttacctcctgtggtctggcggcaatcaacgctgacgatatctggtatttt
gcctccggtggcgtcattggcagcttactaagcactacgctacaaccactgctacacagt
agcgggggaactattgcgctgctctgcgtttgggcagcgggcctgacgttgttcaccggt
tggtcatgggtgaccattgctgaaaaactcggcggctggattttaaacattctcaccttc
gccagtaatcgtacccgtcgcgatgatacctgggtcgatgaagatgagtatgaagacgac
gaagagtatgaagatgaaaatcacggcaaacagcatgaatcacgccgtgcccgtattctt
cgcggcgcgctagcgcgtcgtaaacggttggcggaaaaattcattaatccgatggggcgg
caaacagacgctgcgttgttctccggtaagcggatggatgatgacgaagagattacctac
actgcacgcggtgtggctgccgacccggacgacgtcctattttcgggcaatcgtgcaacg
cagccagaatatgacgaatacgatccattattaaacggtgcgccaattaccgaacctgtc
gctgtagcagctgctgctaccacggcgacacaaagctgggctgcgccggttgaacctgtg
actcagacgccgcctgttgcctctgttgatgttccacctgcgcaacctacagtagcctgg
cagcctgtaccgggtccacaaacgggagagccggttattgctcctgcaccggaaggttac
ccacagcagtcacaatatgcgcagcctgcagtgcaatataatgagccgctgcaacaacca
gtacagccgcagcagccgtattatgcacctgcagctgaacaacctgcgcaacagccgtat
tatgcccctgcgccagaacaaccggtggcaggtaacgcctggcaagccgaagagcagcaa
tccacttttgctccacagtctacataccagactgagcaaacttatcagcagccagccgct
caggagccgttgtaccaacagccgcaacccgttgaacagcagcctgttgtggagcctgaa
cccgttgtagaagagacaaaacccgcgcgtccgccgctttactactttgaagaagttgaa
gagaagcgagcccgtgaacgtgaacaacttgcggcctggtatcaaccgattccagaaccg
gttaaagaaccagaaccgatcaaatcttcgctgaaagcaccttctgttgcagcagtacct
ccagtagaagccgctgccgctgtttccccgctggcatctggcgtgaaaaaagcgacactg
gcgacgggggctgccgcaaccgttgccgcgccagtcttcagtctggcaaatagcggtgga
ccgcgtcctcaggtcaaagaggggattggtccgcagttgccacgaccgaaacgtatccgc
gtgccaactcgtcgtgaactggcgtcttacggtattaagctgccctcacagcgtgcggcg
gaagaaaaagcccgtgaagcccagcgcaatcagtacgattctggcgatcagtacaacgat
gatgaaatcgatgcgatgcagcaggatgaactggcacgtcagttcgcccagacacagcag
caacgctatggcgaacagtatcaacatgatgtgcccgtaaacgcagaagatgcagatgct
gcggcagaggctgaactggctcgtcagtttgcgcaaactcaacaacaacgttattccggc
gaacaaccggctggggcgaatccgttctcgctggatgattttgaattttcgccaatgaaa
gcgttgctggatgatggtccacacgaaccgttgtttacgccaattgttgaacctgtacag
cagccgcaacaaccggttgcaccgcagcagcaatatcagcagccgcaacaaccagttccg
ccgcagccgcagtatcagcagccacaacagccggttgcgccgcagccacaatatcagcag
ccgcaacaaccggttgcgccacagcagcaatatcagcagccgcaacaaccggttgcgccg
cagcagcagtatcagcagccacaacagccagttgcgccacaaccgcaggataccctgctt
catccgctgttgatgcgtaatggcgacagccgtccgttgcataaaccgacgacgccgctg
ccttctctggatttgctgacaccgccgccgagcgaagtggagccggtagatacctttgcg
cttgaacaaatggctcgcctggtggaagcgcgtctggctgatttccgtattaaagccgat
gtcgtcaattactctccggggccggttatcactcgctttgaattgaacctggcaccgggc
gtaaaagcggcgcgcatttctaacttgtcacgggaccttgcccgttcactttcgacggtg
gcggtgcgtgtcgttgaagttattcctggcaaaccctatgtaggtctggagttaccgaat
aaaaaacgacaaaccgtttatctgcgcgaagttttggataacgccaaattccgcgataat
ccgtcgccattaaccgtggtgctgggtaaagatatcgccggtgagccggtggttgccgat
ctggcgaaaatgccgcacttgttggttgcggggactaccggttccggtaaatctgtcggt
gtgaacgcgatgatcctgagcatgctttataaagcacagccagaagatgtgcgtttcatc
atgatcgacccgaaaatgctggagctttcggtttatgaaggcattccgcatctgttaacg
gaagtcgttactgatatgaaagatgccgccaacgcgctgcgctggtgtgttaacgagatg
gagcgtcggtataaactgatgtctgcgctgggtgtgcgtaatctggcgggttataacgaa
aaaattgctgaagccgatcgcatgatgcgtccgattccagacccgtactggaagccgggt
gacagtatggatgcccagcatccggtgctgaaaaaagaaccatacattgtggtgttggtt
gacgaatttgccgacctgatgatgacggtaggtaaaaaagtggaagagctgatagcacgt
ctggcgcaaaaagcccgtgccgcgggtatccacctcgtactggcaactcagcgtccatcg
gttgatgttattactggtctgattaaagcgaatattccgacccgtatcgcctttaccgta
tccagtaagattgactcacgtaccattcttgatcaggctggcgcggaatcactgctgggt
atgggggatatgctctactctgggccgaactccacgttgccggtacgtgtccatggtgct
tttgttcgcgatcaggaagttcatgccgtggtgcaggactggaaagcgcgtggtcgccca
cagtatgttgatggcatcacctccgacagcgaaagcgaaggtggtgcgggtggtttcgat
ggcgctgaagaactggatccgttgttcgatcaggcggtgcagtttgtcactgaaaaacgc
aaagcgtcaatttctggcgtacagcgtcagttccgcattggttataaccgtgcagcgcgt
attatcgaacagatggaagcgcaggggattgtcagcgaacaggggcacaacggtaatcgt
gaagtgctggccccaccgccgtttgactaa |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 1329 |
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| Protein Molecular Weight: | 146661 |
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| Protein Theoretical pI: | Not Available |
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| PDB File: | 2IUS |
| Signaling Regions: | Not Available |
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| Transmembrane Regions: | - 25-44
- 75-98
- 116-132
- 163-179
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| Protein Sequence: | >DNA translocase FtsK
MSQEYIEDKEVTLTKLSSGRRLLEALLILIVLFAVWLMAALLSFNPSDPSWSQTAWHEPI
HNLGGMPGAWLADTLFFIFGVMAYTIPVIIVGGCWFAWRHQSSDEYIDYFAVSLRIIGVL
ALILTSCGLAAINADDIWYFASGGVIGSLLSTTLQPLLHSSGGTIALLCVWAAGLTLFTG
WSWVTIAEKLGGWILNILTFASNRTRRDDTWVDEDEYEDDEEYEDENHGKQHESRRARIL
RGALARRKRLAEKFINPMGRQTDAALFSGKRMDDDEEITYTARGVAADPDDVLFSGNRAT
QPEYDEYDPLLNGAPITEPVAVAAAATTATQSWAAPVEPVTQTPPVASVDVPPAQPTVAW
QPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPY
YAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQPVVEPE
PVVEETKPARPPLYYFEEVEEKRAREREQLAAWYQPIPEPVKEPEPIKSSLKAPSVAAVP
PVEAAAAVSPLASGVKKATLATGAAATVAAPVFSLANSGGPRPQVKEGIGPQLPRPKRIR
VPTRRELASYGIKLPSQRAAEEKAREAQRNQYDSGDQYNDDEIDAMQQDELARQFAQTQQ
QRYGEQYQHDVPVNAEDADAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDDFEFSPMK
ALLDDGPHEPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVPPQPQYQQPQQPVAPQPQYQQ
PQQPVAPQQQYQQPQQPVAPQQQYQQPQQPVAPQPQDTLLHPLLMRNGDSRPLHKPTTPL
PSLDLLTPPPSEVEPVDTFALEQMARLVEARLADFRIKADVVNYSPGPVITRFELNLAPG
VKAARISNLSRDLARSLSTVAVRVVEVIPGKPYVGLELPNKKRQTVYLREVLDNAKFRDN
PSPLTVVLGKDIAGEPVVADLAKMPHLLVAGTTGSGKSVGVNAMILSMLYKAQPEDVRFI
MIDPKMLELSVYEGIPHLLTEVVTDMKDAANALRWCVNEMERRYKLMSALGVRNLAGYNE
KIAEADRMMRPIPDPYWKPGDSMDAQHPVLKKEPYIVVLVDEFADLMMTVGKKVEELIAR
LAQKARAAGIHLVLATQRPSVDVITGLIKANIPTRIAFTVSSKIDSRTILDQAGAESLLG
MGDMLYSGPNSTLPVRVHGAFVRDQEVHAVVQDWKARGRPQYVDGITSDSESEGGAGGFD
GAEELDPLFDQAVQFVTEKRKASISGVQRQFRIGYNRAARIIEQMEAQGIVSEQGHNGNR
EVLAPPPFD |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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