Identification |
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Name: | Chaperone protein ClpB |
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Synonyms: | Not Available |
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Gene Name: | clpB |
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Enzyme Class: | Not Available |
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Biological Properties |
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General Function: | response to unfolded protein |
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Specific Function: | Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK. |
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Cellular Location: | Not Available |
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SMPDB Pathways: | Not Available |
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KEGG Pathways: | Not Available |
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Metabolites: | |
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GO Classification: | Function |
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ATP binding | cytosol | identical protein binding | membrane | protein processing | response to heat | response to unfolded protein |
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Gene Properties |
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Blattner: | Not Available |
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Gene Orientation | Not Available |
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Centisome Percentage: | Not Available |
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Left Sequence End | Not Available |
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Right Sequence End | Not Available |
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Gene Sequence: | >2574
atgcgtctggatcgtcttactaataaattccagcttgctcttgccgatgcccaatcactt
gcactcgggcacgacaaccaatttatcgaaccacttcatttaatgagcgccctgctgaat
caggaagggggttcggttagtcctttattaacatccgctggcataaatgctggccagttg
cgcacagatatcaatcaggcattaaatcgtttaccgcaggttgaaggtactggtggtgat
gtccagccatcacaggatctggtgcgcgttcttaatctttgcgacaagctggcgcaaaaa
cgtggtgataactttatctcgtcagaactgttcgttctggcggcacttgagtctcgcggc
acgctggccgacatcctgaaagcagcaggggcgaccaccgccaacattactcaagcgatt
gaacaaatgcgtggaggtgaaagcgtgaacgatcaaggtgctgaagaccaacgtcaggct
ttgaaaaaatataccatcgaccttaccgaacgagccgaacagggcaaactcgatccggtg
attggtcgtgatgaagaaattcgccgtaccattcaggtgctgcaacgtcgtactaaaaat
aacccggtactgattggtgaacccggcgtcggtaaaactgccatcgttgaaggtctggcg
cagcgtattatcaacggcgaagtgccggaagggttgaaaggccgccgggtactggcgctg
gatatgggcgcgctggtggctggggcgaaatatcgcggtgagtttgaagaacgtttaaaa
ggcgtgcttaacgatcttgccaaacaggaaggcaacgtcatcctatttatcgacgaatta
cataccatggtcggcgcgggtaaagccgatggcgcaatggacgccggaaacatgctgaaa
ccggcgctggcgcgtggtgaattgcactgcgtaggtgccacgacgcttgacgaatatcgc
cagtacattgaaaaagatgctgcgctggaacgtcgtttccagaaagtgtttgttgccgag
ccttctgttgaagataccattgcgattctgcgtggcctgaaagaacgttacgaattgcac
caccatgtgcaaattactgacccggcaattgttgcagcggcgacgttgtctcatcgctac
attgctgaccgtcagctgccggataaagccatcgacctgatcgatgaagcagcatccagc
attcgtatgcagattgactcaaaaccagaagaactcgaccgactcgatcgtcgtatcatc
cagctcaaactggaacaacaggcgttaatgaaagagtctgatgaagccagtaaaaaacgt
ctggatatgctcaacgaagaactgagcgacaaagaacgtcagtactccgagttagaagaa
gagtggaaagcagagaaggcatcgctttctggtacgcagaccattaaagcggaactggaa
caggcgaaaatcgctattgaacaggctcgccgtgtgggggacctggcgcggatgtctgaa
ctgcaatacggcaaaatcccggaactggaaaagcaactggaagccgcaacgcagctcgaa
ggcaaaactatgcgtctgttgcgtaataaagtgaccgacgccgaaattgctgaagtgctg
gcgcgttggacggggattccggtttctcgcatgatggaaagcgagcgcgaaaaactgctg
cgtatggagcaagaactgcaccatcgcgtaattggtcagaacgaagcggttgatgcggta
tctaacgctattcgtcgtagccgtgcggggctggcggatccaaatcgcccgattggttca
ttcctgttcctcggcccaactggtgtggggaaaacagagctttgtaaggcgctggcgaac
tttatgtttgatagcgacgaggcgatggtccgtatcgatatgtccgagtttatggagaaa
cactcggtgtctcgtttggttggtgcgcctccgggatatgtcggttatgaagaaggtggc
tacctgaccgaagcggtgcgtcgtcgtccgtattccgtcatcctgctggatgaagtggaa
aaagcgcatccggatgtcttcaacattctgttgcaggtactggatgatgggcgtctgact
gacgggcaagggagaacggtcgacttccgtaatacggtcgtcattatgacctctaacctc
ggttccgatctgattcaggaacgcttcggtgaactggattatgcgcacatgaaagagctg
gtgctcggtgtggtaagccataacttccgtccggaattcattaaccgtatcgatgaagtg
gtggtcttccatccgctgggtgaacagcacattgcctcgattgcgcagattcagttgaaa
cgtctgtacaaacgtctggaagaacgtggttatgaaatccacatttctgacgaggcgctg
aaactgctgagcgagaacggttacgatccggtctatggtgcacgtcctctgaaacgtgca
attcagcagcagatcgaaaacccgctggcacagcaaatactgtctggtgaattggttccg
ggtaaagtgattcgcctggaagttaatgaagaccggattgtcgccgtccagtaa |
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Protein Properties |
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Pfam Domain Function: | Not Available |
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Protein Residues: | 857 |
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Protein Molecular Weight: | 95584 |
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Protein Theoretical pI: | Not Available |
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PDB File: | 1JBK |
Signaling Regions: | Not Available |
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Transmembrane Regions: | Not Available |
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Protein Sequence: | >Chaperone protein ClpB
MRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLNQEGGSVSPLLTSAGINAGQL
RTDINQALNRLPQVEGTGGDVQPSQDLVRVLNLCDKLAQKRGDNFISSELFVLAALESRG
TLADILKAAGATTANITQAIEQMRGGESVNDQGAEDQRQALKKYTIDLTERAEQGKLDPV
IGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKGRRVLAL
DMGALVAGAKYRGEFEERLKGVLNDLAKQEGNVILFIDELHTMVGAGKADGAMDAGNMLK
PALARGELHCVGATTLDEYRQYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKERYELH
HHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEAASSIRMQIDSKPEELDRLDRRII
QLKLEQQALMKESDEASKKRLDMLNEELSDKERQYSELEEEWKAEKASLSGTQTIKAELE
QAKIAIEQARRVGDLARMSELQYGKIPELEKQLEAATQLEGKTMRLLRNKVTDAEIAEVL
ARWTGIPVSRMMESEREKLLRMEQELHHRVIGQNEAVDAVSNAIRRSRAGLADPNRPIGS
FLFLGPTGVGKTELCKALANFMFDSDEAMVRIDMSEFMEKHSVSRLVGAPPGYVGYEEGG
YLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
GSDLIQERFGELDYAHMKELVLGVVSHNFRPEFINRIDEVVVFHPLGEQHIASIAQIQLK
RLYKRLEERGYEIHISDEALKLLSENGYDPVYGARPLKRAIQQQIENPLAQQILSGELVP
GKVIRLEVNEDRIVAVQ |
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References |
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External Links: | |
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General Reference: | Not Available |
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