Identification
Name:Chaperone protein ClpB
Synonyms:Not Available
Gene Name:clpB
Enzyme Class:Not Available
Biological Properties
General Function:response to unfolded protein
Specific Function:Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
ATP binding
cytosol
identical protein binding
membrane
protein processing
response to heat
response to unfolded protein
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>2574
atgcgtctggatcgtcttactaataaattccagcttgctcttgccgatgcccaatcactt
gcactcgggcacgacaaccaatttatcgaaccacttcatttaatgagcgccctgctgaat
caggaagggggttcggttagtcctttattaacatccgctggcataaatgctggccagttg
cgcacagatatcaatcaggcattaaatcgtttaccgcaggttgaaggtactggtggtgat
gtccagccatcacaggatctggtgcgcgttcttaatctttgcgacaagctggcgcaaaaa
cgtggtgataactttatctcgtcagaactgttcgttctggcggcacttgagtctcgcggc
acgctggccgacatcctgaaagcagcaggggcgaccaccgccaacattactcaagcgatt
gaacaaatgcgtggaggtgaaagcgtgaacgatcaaggtgctgaagaccaacgtcaggct
ttgaaaaaatataccatcgaccttaccgaacgagccgaacagggcaaactcgatccggtg
attggtcgtgatgaagaaattcgccgtaccattcaggtgctgcaacgtcgtactaaaaat
aacccggtactgattggtgaacccggcgtcggtaaaactgccatcgttgaaggtctggcg
cagcgtattatcaacggcgaagtgccggaagggttgaaaggccgccgggtactggcgctg
gatatgggcgcgctggtggctggggcgaaatatcgcggtgagtttgaagaacgtttaaaa
ggcgtgcttaacgatcttgccaaacaggaaggcaacgtcatcctatttatcgacgaatta
cataccatggtcggcgcgggtaaagccgatggcgcaatggacgccggaaacatgctgaaa
ccggcgctggcgcgtggtgaattgcactgcgtaggtgccacgacgcttgacgaatatcgc
cagtacattgaaaaagatgctgcgctggaacgtcgtttccagaaagtgtttgttgccgag
ccttctgttgaagataccattgcgattctgcgtggcctgaaagaacgttacgaattgcac
caccatgtgcaaattactgacccggcaattgttgcagcggcgacgttgtctcatcgctac
attgctgaccgtcagctgccggataaagccatcgacctgatcgatgaagcagcatccagc
attcgtatgcagattgactcaaaaccagaagaactcgaccgactcgatcgtcgtatcatc
cagctcaaactggaacaacaggcgttaatgaaagagtctgatgaagccagtaaaaaacgt
ctggatatgctcaacgaagaactgagcgacaaagaacgtcagtactccgagttagaagaa
gagtggaaagcagagaaggcatcgctttctggtacgcagaccattaaagcggaactggaa
caggcgaaaatcgctattgaacaggctcgccgtgtgggggacctggcgcggatgtctgaa
ctgcaatacggcaaaatcccggaactggaaaagcaactggaagccgcaacgcagctcgaa
ggcaaaactatgcgtctgttgcgtaataaagtgaccgacgccgaaattgctgaagtgctg
gcgcgttggacggggattccggtttctcgcatgatggaaagcgagcgcgaaaaactgctg
cgtatggagcaagaactgcaccatcgcgtaattggtcagaacgaagcggttgatgcggta
tctaacgctattcgtcgtagccgtgcggggctggcggatccaaatcgcccgattggttca
ttcctgttcctcggcccaactggtgtggggaaaacagagctttgtaaggcgctggcgaac
tttatgtttgatagcgacgaggcgatggtccgtatcgatatgtccgagtttatggagaaa
cactcggtgtctcgtttggttggtgcgcctccgggatatgtcggttatgaagaaggtggc
tacctgaccgaagcggtgcgtcgtcgtccgtattccgtcatcctgctggatgaagtggaa
aaagcgcatccggatgtcttcaacattctgttgcaggtactggatgatgggcgtctgact
gacgggcaagggagaacggtcgacttccgtaatacggtcgtcattatgacctctaacctc
ggttccgatctgattcaggaacgcttcggtgaactggattatgcgcacatgaaagagctg
gtgctcggtgtggtaagccataacttccgtccggaattcattaaccgtatcgatgaagtg
gtggtcttccatccgctgggtgaacagcacattgcctcgattgcgcagattcagttgaaa
cgtctgtacaaacgtctggaagaacgtggttatgaaatccacatttctgacgaggcgctg
aaactgctgagcgagaacggttacgatccggtctatggtgcacgtcctctgaaacgtgca
attcagcagcagatcgaaaacccgctggcacagcaaatactgtctggtgaattggttccg
ggtaaagtgattcgcctggaagttaatgaagaccggattgtcgccgtccagtaa
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:857
Protein Molecular Weight:95584
Protein Theoretical pI:Not Available
PDB File:1JBK
Signaling Regions:Not Available
Transmembrane Regions:Not Available
Protein Sequence:
>Chaperone protein ClpB
MRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLNQEGGSVSPLLTSAGINAGQL
RTDINQALNRLPQVEGTGGDVQPSQDLVRVLNLCDKLAQKRGDNFISSELFVLAALESRG
TLADILKAAGATTANITQAIEQMRGGESVNDQGAEDQRQALKKYTIDLTERAEQGKLDPV
IGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKGRRVLAL
DMGALVAGAKYRGEFEERLKGVLNDLAKQEGNVILFIDELHTMVGAGKADGAMDAGNMLK
PALARGELHCVGATTLDEYRQYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKERYELH
HHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEAASSIRMQIDSKPEELDRLDRRII
QLKLEQQALMKESDEASKKRLDMLNEELSDKERQYSELEEEWKAEKASLSGTQTIKAELE
QAKIAIEQARRVGDLARMSELQYGKIPELEKQLEAATQLEGKTMRLLRNKVTDAEIAEVL
ARWTGIPVSRMMESEREKLLRMEQELHHRVIGQNEAVDAVSNAIRRSRAGLADPNRPIGS
FLFLGPTGVGKTELCKALANFMFDSDEAMVRIDMSEFMEKHSVSRLVGAPPGYVGYEEGG
YLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
GSDLIQERFGELDYAHMKELVLGVVSHNFRPEFINRIDEVVVFHPLGEQHIASIAQIQLK
RLYKRLEERGYEIHISDEALKLLSENGYDPVYGARPLKRAIQQQIENPLAQQILSGELVP
GKVIRLEVNEDRIVAVQ
References
External Links:
ResourceLink
Uniprot ID:P63284
Uniprot Name:CLPB_ECOLI
PDB ID:1JBK
CCDB:CLPB_ECOLI
General Reference:Not Available