ECMDB: mRNA interferase HigB (P64578)

Identification

Name:

mRNA interferase HigB

Synonyms:

Not Available

Gene Name:

higB

Enzyme Class:

Not Available

Biological Properties

General Function:

RNA phosphodiester bond hydrolysis, endonucleolytic

Specific Function:

Toxic component of a toxin-antitoxin (TA) module. A probable translation-dependent mRNA interferase. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation; this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase.

Cellular Location:

Not Available

SMPDB Pathways:

Not Available

KEGG Pathways:

Not Available

Metabolites:

ECMDB ID	Name	View

GO Classification:

Function
endoribonuclease activity
negative regulation of translation
regulation of mRNA stability
RNA binding
RNA phosphodiester bond hydrolysis, endonucleolytic

Gene Properties

Blattner:

Not Available

Gene Orientation

Not Available

Centisome Percentage:

Not Available

Left Sequence End

Not Available

Right Sequence End

Not Available

Gene Sequence:

>315
atgcacctgataactcaaaaagcattgaaagatgctgcggaaaaatacccgcaacataaa
acggagttggtggctctggggaacacgattgctaagggatatttcaaaaaacctgagtca
ttaaaagcagtattcccatctctggataacttcaaatatctggataagcattatgttttc
aatgttgggggcaatgaattacgtgttgtagcaatggtcttttttgaatcgcaaaagtgc
tacatacgtgaagttatgacgcataaagaatacgatttctttaccgctgttcatcgtact
aaggggaaaaaatga

Protein Properties

Pfam Domain Function:

Not Available

Protein Residues:

104

Protein Molecular Weight:

12103

Protein Theoretical pI:

Not Available

Signaling Regions:

Not Available

Transmembrane Regions:

Not Available

Protein Sequence:

>mRNA interferase HigB
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVF
NVGGNELRVVAMVFFESQKCYIREVMTHKEYDFFTAVHRTKGKK

References

External Links:

Resource	Link
Uniprot ID:	P64578
Uniprot Name:	HIGB_ECOLI
CCDB:	HIGB_ECOLI

General Reference:

Not Available