Identification
Name:Toxin YhaV
Synonyms:Not Available
Gene Name:yhaV
Enzyme Class:Not Available
Biological Properties
General Function:transcription, DNA-templated
Specific Function:Toxic component of a toxin-antitoxin (TA) module. Has RNase activity in vitro. Overexpression leads to growth arrest after 30 minutes; these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV/PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression.
Cellular Location:Not Available
SMPDB Pathways:Not Available
KEGG Pathways:Not Available
Metabolites:
ECMDB IDNameView
GO Classification:
Function
endoribonuclease activity
negative regulation of cell growth
negative regulation of transcription, DNA-templated
RNA phosphodiester bond hydrolysis, endonucleolytic
transcription, DNA-templated
Gene Properties
Blattner:Not Available
Gene OrientationNot Available
Centisome Percentage:Not Available
Left Sequence EndNot Available
Right Sequence EndNot Available
Gene Sequence:
>465
atggattttccacaaagggttaatggttgggcgctatatgctcatccctgttttcaggaa
acctacgacgctttagttgccgaagtcgagacattaaagggaaaagatcctgaaaattat
cagagaaaagccgccacaaagttattggcggtagtccataaagtgattgaggagcatatc
acggtcaatccatcatcaccggcattccgtcatggcaagtcgttaggctctgggaaaaat
aaagactggtcacgggtaaaatttggtgctggtcgttatcgtctcttctttcgttatagt
gaaaaagagaaagtcatcattctgggatggatgaacgatgaaaacactctgcgcacctac
ggtaaaaaaacagatgcctataccgtattcagcaaaatgttaaaaagaggacatcctcct
gccgactgggaaaccctcacccgagaaacagaagaaacccattga
Protein Properties
Pfam Domain Function:Not Available
Protein Residues:154
Protein Molecular Weight:17836
Protein Theoretical pI:Not Available
Signaling Regions:Not Available
Transmembrane Regions:Not Available
Protein Sequence:
>Toxin YhaV
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHI
TVNPSSPAFRHGKSLGSGKNKDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTY
GKKTDAYTVFSKMLKRGHPPADWETLTRETEETH
References
External Links:
ResourceLink
Uniprot ID:P64594
Uniprot Name:YHAV_ECOLI
CCDB:YHAV_ECOLI
General Reference:Not Available