ECMDB: Toxin GhoT (P64646)

Identification

Name:

Toxin GhoT

Synonyms:

Not Available

Gene Name:

ghoT

Enzyme Class:

Not Available

Biological Properties

General Function:

cell death

Specific Function:

Toxic component of a type V toxin-antitoxin (TA) module. Causes membrane damage when induced by MqsR, slowing cell growth and increasing the formation of dormant persister cells; involved with GhoS, its antitoxin, in reducing cell growth during antibacterial stress (PubMed:24373067). Overexpression causes cell lysis, forming ghost cells; both effects are neutralized by expression of GhoS. Overexpression in the presence of ampicillin increases persister cell formation (persister cells exhibit antibiotic tolerance without genetic change) (PubMed:22941047). Overexpression causes about 90-fold reduction in cellular ATP levels and dissipates the membrane potential (PubMed:24373067).

Cellular Location:

Not Available

SMPDB Pathways:

Not Available

KEGG Pathways:

Not Available

Metabolites:

ECMDB ID	Name	View

GO Classification:

Function
cell death
cell pole
integral component of membrane
membrane
plasma membrane

Gene Properties

Blattner:

Not Available

Gene Orientation

Not Available

Centisome Percentage:

Not Available

Left Sequence End

Not Available

Right Sequence End

Not Available

Gene Sequence:

>174
atggcactattctctaaaatattaattttttatgtgattggtgtgaacatatcctttgtc
attatctggtttatctcacatgagaaaacacatattcgtttacttagtgcattcctggtc
ggaataacctggccaatgagtctgcctgtggcattacttttttctctcttttag

Protein Properties

Pfam Domain Function:

Not Available

Protein Residues:

Protein Molecular Weight:

6554

Protein Theoretical pI:

Not Available

Signaling Regions:

Not Available

Transmembrane Regions:

7-27
37-57

Protein Sequence:

>Toxin GhoT
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

References

External Links:

Resource	Link
Uniprot ID:	P64646
Uniprot Name:	GHOT_ECOLI
CCDB:	GHOT_ECOLI

General Reference:

Not Available