ECMDB

Identification

Name:

Formyl-coenzyme A transferase

Synonyms:

Formyl-CoA transferase

Gene Name:

frc

Enzyme Class:

2.8.3.16

Biological Properties

General Function:

Involved in catalytic activity

Specific Function:

Catalyzes the transfer of the CoA moiety from formyl-CoA to oxalate

Cellular Location:

Not Available

SMPDB Pathways:

Not Available

KEGG Pathways:

Not Available

EcoCyc Reactions:

1.0

↔

1.0

1.0Formyl-CoA + 1.0Oxalic acid ↔ 1.0Formic acid + 1.0Oxalyl-CoA
ReactionCard

Complex Reactions:

1.0

→

1.0

1.0Formyl-CoA + 1.0Oxalic acid → 1.0Formic acid + 1.0Oxalyl-CoA
ReactionCard

Metabolites:

ECMDB ID	Name	View
ECMDB00142	Formic acid	MetaboCard
ECMDB03419	Formyl-CoA	MetaboCard
ECMDB02329	Oxalic acid	MetaboCard
ECMDB20182	Oxalyl-CoA	MetaboCard

GO Classification:

Function
catalytic activity
CoA-transferase activity
formyl-CoA transferase activity
transferase activity
transferase activity, transferring sulfur-containing groups
Process
metabolic process

Gene Properties

Blattner:

b2374

Gene Orientation

Counterclockwise

Centisome Percentage:

53.67

Left Sequence End

2490026

Right Sequence End

2491276

Gene Sequence:

>1251 bp
ATGAATAAACAATCCTGGCTGCTTAACCTCAGCCTGTTGAAAACGCACCCGGCGTTTCGC
GCAGTATTCCTCGCTCGTTTCATCTCAATTGTGTCTCTGGGTTTGCTCGGCGTCGCGGTG
CCGGTGCAGATCCAGATGATGACACATTCCACCTGGCAGGTGGGGCTTTCGGTGACGCTG
ACCGGCGGCGCGATGTTTGTTGGCCTGATGGTCGGCGGTGTGCTGGCGGATCGCTATGAG
CGCAAAAAAGTGATTTTGCTGGCGCGCGGCACCTGTGGCATTGGCTTCATTGGACTGTGC
CTTAATGCACTGCTGCCGGAGCCGTCATTGCTGGCAATCTATTTACTTGGTTTATGGGAT
GGTTTTTTCGCATCGCTTGGCGTTACGGCGCTATTGGCGGCGACACCAGCACTGGTAGGG
CGTGAAAACTTAATGCAGGCCGGGGCGATCACCATGTTGACCGTGCGTCTGGGGTCGGTG
ATTTCGCCCATGATTGGCGGTTTATTGCTGGCGACCGGTGGCGTAGCCTGGAACTACGGG
CTGGCGGCGGCGGGCACGTTTATTACCTTGCTACCGTTGTTAAGCCTTCCGGCGTTGCCA
CCGCCACCGCAGCCGCGTGAGCATCCGTTGAAATCATTACTGGCAGGATTTCGTTTTCTG
CTTGCCAGCCCGCTGGTGGGCGGGATTGCGCTGCTGGGTGGTTTATTGACGATGGCGAGC
GCGGTGCGGGTACTGTATCCGGCGCTGGCTGACAACTGGCAGATGTCAGCGGCACAGATT
GGTTTTCTCTACGCGGCGATCCCGCTCGGCGCGGCTATTGGTGCGTTAACCAGCGGGAAG
CTGGCACATAGTGCGCGACCAGGGTTATTGATGCTGCTCTCCACGCTGGGATCGTTCCTC
GCCATTGGTCTGTTTGGCCTGATGCCGATGTGGATTTTAGGCGTGGTTTGTCTGGCGCTG
TTCGGCTGGTTGAGTGCGGTCAGCTCGTTGCTGCAATACACAATGCTGCAAACGCAAACC
CCGGAAGCGATGTTAGGGCGGATTAACGGTTTGTGGACGGCGCAGAACGTGACGGGCGAT
GCCATAGGCGCGGCGCTGCTGGGTGGTTTGGGCGCGATGATGACACCGGTTGCTTCCGCA
AGCGCGAGCGGTTTTGGTTTGTTGATTATCGGCGTGTTGTTATTGCTGGTGCTGGTGGAG
TTGCGACATTTTCGCCAGACGCCGCCGCAGGTGACAGCGTCCGACAGTTAA

Protein Properties

Pfam Domain Function:

CoA_transf_3 (PF02515 )

Protein Residues:

416

Protein Molecular Weight:

45828

Protein Theoretical pI:

PDB File:

1PT8

Signaling Regions:

None

Transmembrane Regions:

None

Protein Sequence:

>Formyl-coenzyme A transferase
MSTPLQGIKVLDFTGVQSGPSCTQMLAWFGADVIKIERPGVGDVTRHQLRDIPDIDALYF
TMLNSNKRSIELNTKTAEGKEVMEKLIREADILVENFHPGAIDHMGFTWEHIQEINPRLI
FGSIKGFDECSPYVNVKAYENVAQAAGGAASTTGFWDGPPLVSAAALGDSNTGMHLLIGL
LAALLHREKTGRGQRVTMSMQDAVLNLCRVKLRDQQRLDKLGYLEEYPQYPNGTFGDAVP
RGGNAGGGGQPGWILKCKGWETDPNAYIYFTIQEQNWENTCKAIGKPEWITDPAYSTAHA
RQPHIFDIFAEIEKYTVTIDKHEAVAYLTQFDIPCAPVLSMKEISLDPSLRQSGSVVEVE
QPLRGKYLTVGCPMKFSAFTPDIKAAPLLGEHTAAVLQELGYSDDEIAAMKQNHAI

References

External Links:

Resource	Link
Uniprot ID:	P69902
Uniprot Name:	FCTA_ECOLI
GenBank Gene ID:	AP009048
Genebank Protein ID:	85674712
PDB ID:	1PT8
Ecogene ID:	EG14145
Ecocyc:	EG14145
ColiBase:	b2374
Kegg Gene:	b2374
EchoBASE ID:	EB3897
CCDB:	FCTA_ECOLI
BacMap:	16130306

General Reference:

Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
Gruez, A., Roig-Zamboni, V., Valencia, C., Campanacci, V., Cambillau, C. (2003). "The crystal structure of the Escherichia coli YfdW gene product reveals a new fold of two interlaced rings identifying a wide family of CoA transferases." J Biol Chem 278:34582-34586. Pubmed: 12844490
Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
Yamamoto, Y., Aiba, H., Baba, T., Hayashi, K., Inada, T., Isono, K., Itoh, T., Kimura, S., Kitagawa, M., Makino, K., Miki, T., Mitsuhashi, N., Mizobuchi, K., Mori, H., Nakade, S., Nakamura, Y., Nashimoto, H., Oshima, T., Oyama, S., Saito, N., Sampei, G., Satoh, Y., Sivasundaram, S., Tagami, H., Horiuchi, T., et, a. l. .. (1997). "Construction of a contiguous 874-kb sequence of the Escherichia coli -K12 genome corresponding to 50.0-68.8 min on the linkage map and analysis of its sequence features." DNA Res 4:91-113. Pubmed: 9205837

Formyl-coenzyme A transferase (P69902)