ECMDB: Probable mRNA interferase HicA (P76106)

Identification

Name:

Probable mRNA interferase HicA

Synonyms:

Not Available

Gene Name:

hicA

Enzyme Class:

Not Available

Biological Properties

General Function:

RNA phosphodiester bond hydrolysis, endonucleolytic

Specific Function:

Toxic component of a toxin-antitoxin (TA) module. A probable translation-independent mRNA interferase. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation; this blockage is overcome (after 90 minutes) by subsequent expression of antitoxin HicB. Overexpression causes cleavage of a number of mRNAs and tmRNA, in a translation-independent fashion, suggesting this is an mRNA interferase.

Cellular Location:

Not Available

SMPDB Pathways:

Not Available

KEGG Pathways:

Not Available

Metabolites:

ECMDB ID	Name	View

GO Classification:

Function
endoribonuclease activity
mRNA binding
mRNA catabolic process
RNA phosphodiester bond hydrolysis, endonucleolytic

Gene Properties

Blattner:

Not Available

Gene Orientation

Not Available

Centisome Percentage:

Not Available

Left Sequence End

Not Available

Right Sequence End

Not Available

Gene Sequence:

>177
gtgaaacaaagcgagttcagacgttggctcgaatctcagggcgtcgatgtagcgaatggc
agcaaccatttgaaactcaggtttcatgggaggcgcagtgtcatgccgcgtcacccctgc
gatgagattaaagaaccattgcgtaaagcaatcctgaaacaactcggtttgagttaa

Protein Properties

Pfam Domain Function:

Not Available

Protein Residues:

Protein Molecular Weight:

6781

Protein Theoretical pI:

Not Available

Signaling Regions:

Not Available

Transmembrane Regions:

Not Available

Protein Sequence:

>Probable mRNA interferase HicA
MKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

References

External Links:

Resource	Link
Uniprot ID:	P76106
Uniprot Name:	HICA_ECOLI
CCDB:	HICA_ECOLI

General Reference:

Not Available