| Identification |
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| Name: | Excinuclease cho |
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| Synonyms: | Not Available |
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| Gene Name: | cho |
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| Enzyme Class: | Not Available |
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| Biological Properties |
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| General Function: | SOS response |
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| Specific Function: | Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. In vitro, the incision activity of Cho is UvrA and UvrB dependent. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair. |
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| Cellular Location: | Not Available |
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| SMPDB Pathways: | Not Available |
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| KEGG Pathways: | Not Available |
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| Metabolites: | |
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| GO Classification: | | Function |
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| cellular response to DNA damage stimulus | | DNA repair | | nuclease activity | | SOS response |
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| Gene Properties |
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| Blattner: | Not Available |
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| Gene Orientation | Not Available |
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| Centisome Percentage: | Not Available |
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| Left Sequence End | Not Available |
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| Right Sequence End | Not Available |
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| Gene Sequence: | >888
gtggtacggcgtttaacttctccgcggctcgaatttgaagctgcggcaatttatgaatat
cccgaacatttacgttcattccttaatgacttacccacccgaccaggggtgtatctgttt
catggtgaaagtgacaccatgccgctctatatcggcaaaagcgttaacatccgcagccgc
gtcctttctcatttacgtaccccggatgaagccgccatgctacggcaatcccgacggatc
agctggatatgtaccgccggtgaaatcggcgctctgctccttgaagcgcgattaatcaaa
gaacaacagccgctgtttaataaacggttgcgccgcaatcgccagctctgtgccctgcaa
ttaaatgaaaagcgcgtcgatgtggtgtatgccaaagaggtggatttttcacgagccccc
aacctgtttggcctgtttgccaataggcgcgcagctttgcaagcattgcagaccatcgct
gatgaacaaaaactttgttatggcctgctgggactggaaccgttaagtcgcggtcgtgca
tgttttcgttcagcgctaaaacgttgcgccggagcatgctgcggtaaagagagccatgag
gaacatgcgctacgcttgcgccagtctctggagcgtttgcgggtggtgtgttggccttgg
caaggggcggtggcgctgaaagaacagcacccggaaatgactcaatatcatattattcaa
aactggctgtggctgggggcggttaattcgctggaagaagcgacaacgttaattcggaca
cccgccgggtttgatcacgacggttataaaattctttgtaagccgctgctttccggtaac
tatgaaattactgaacttgatccggcgaatgaccagcgagccagttga |
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| Protein Properties |
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| Pfam Domain Function: | Not Available |
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| Protein Residues: | 295 |
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| Protein Molecular Weight: | 33738 |
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| Protein Theoretical pI: | Not Available |
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| Signaling Regions: | Not Available |
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| Transmembrane Regions: | Not Available |
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| Protein Sequence: | >Excinuclease cho
MVRRLTSPRLEFEAAAIYEYPEHLRSFLNDLPTRPGVYLFHGESDTMPLYIGKSVNIRSR
VLSHLRTPDEAAMLRQSRRISWICTAGEIGALLLEARLIKEQQPLFNKRLRRNRQLCALQ
LNEKRVDVVYAKEVDFSRAPNLFGLFANRRAALQALQTIADEQKLCYGLLGLEPLSRGRA
CFRSALKRCAGACCGKESHEEHALRLRQSLERLRVVCWPWQGAVALKEQHPEMTQYHIIQ
NWLWLGAVNSLEEATTLIRTPAGFDHDGYKILCKPLLSGNYEITELDPANDQRAS |
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| References |
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| External Links: | |
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| General Reference: | Not Available |
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