Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE (Q47377)

Identification
Name:Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE
Synonyms:
  • L-Ara4N-phosphoundecaprenol flippase subunit ArnE
  • Undecaprenyl phosphate-aminoarabinose flippase subunit ArnE
Gene Name:arnE
Enzyme Class:Not Available
Biological Properties
General Function:Carbohydrate transport and metabolism
Specific Function:Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane
Cellular Location:Cell inner membrane; Multi-pass membrane protein
SMPDB Pathways:Not Available
KEGG Pathways:
  • Cationic antimicrobial peptide (CAMP) resistance eco01503
Transports:
Transport References:
  • Orth, J. D., Conrad, T. M., Na, J., Lerman, J. A., Nam, H., Feist, A. M., Palsson, B. O. (2011). "A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011." Mol Syst Biol 7:535. Pubmed: 21988831
Metabolites:
ECMDB IDNameView
ECMDB21364undecaprenyl phosphate-4-amino-4-deoxy-L-arabinoseMetaboCard
GO Classification:
Component
cell part
membrane
Gene Properties
Blattner:b4544
Gene OrientationClockwise
Centisome Percentage:51.09
Left Sequence End2370579
Right Sequence End2370914
Gene Sequence:
>336 bp
ATGATCTGGCTAACATTAGTCTTTGCCAGCTTGCTTAGCGTTGCCGGGCAGTTGTGTCAG
AAACAGGCAACCTGCTTTGTGGCGATAAACAAACGGCGCAAACATATCGTGCTGTGGCTG
GGACTGGCGCTGGCTTGTCTTGGTCTTGCCATGGTGCTCTGGCTGCTGGTCTTGCAGAAC
GTACCGGTAGGCATTGCTTACCCGATGTTAAGTCTGAATTTTGTCTGGGTGACGCTGGCT
GCAGTAAAACTGTGGCACGAACCGGTATCGCCGCGTCACTGGTGTGGGGTGGCGTTCATT
ATTGGCGGCATTGTGATCCTCGGGAGTACGGTGTAA
Protein Properties
Pfam Domain Function:
Protein Residues:111
Protein Molecular Weight:12192
Protein Theoretical pI:10
Signaling Regions:
  • None
Transmembrane Regions:
  • 36-56
  • 62-82
  • 88-108
Protein Sequence:
>Probable 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE
MIWLTLVFASLLSVAGQLCQKQATCFVAINKRRKHIVLWLGLALACLGLAMVLWLLVLQN
VPVGIAYPMLSLNFVWVTLAAVKLWHEPVSPRHWCGVAFIIGGIVILGSTV
References
External Links:
ResourceLink
Uniprot ID:Q47377
Uniprot Name:ARNE_ECOLI
GenBank Gene ID:AP009048
Genebank Protein ID:85675327
Ecogene ID:EG14344
Ecocyc:EG14344
ColiBase:b4544
Kegg Gene:b4544
EchoBASE ID:EB4090
CCDB:ARNE_ECOLI
BacMap:94541119
General Reference:
  • Blattner, F. R., Plunkett, G. 3rd, Bloch, C. A., Perna, N. T., Burland, V., Riley, M., Collado-Vides, J., Glasner, J. D., Rode, C. K., Mayhew, G. F., Gregor, J., Davis, N. W., Kirkpatrick, H. A., Goeden, M. A., Rose, D. J., Mau, B., Shao, Y. (1997). "The complete genome sequence of Escherichia coli K-12." Science 277:1453-1462. Pubmed: 9278503
  • Daley, D. O., Rapp, M., Granseth, E., Melen, K., Drew, D., von Heijne, G. (2005). "Global topology analysis of the Escherichia coli inner membrane proteome." Science 308:1321-1323. Pubmed: 15919996
  • Hayashi, K., Morooka, N., Yamamoto, Y., Fujita, K., Isono, K., Choi, S., Ohtsubo, E., Baba, T., Wanner, B. L., Mori, H., Horiuchi, T. (2006). "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Mol Syst Biol 2:2006.0007. Pubmed: 16738553
  • Sharma, V., Hudspeth, M. E., Meganathan, R. (1996). "Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menE gene from Escherichia coli." Gene 168:43-48. Pubmed: 8626063
  • Yan, A., Guan, Z., Raetz, C. R. (2007). "An undecaprenyl phosphate-aminoarabinose flippase required for polymyxin resistance in Escherichia coli." J Biol Chem 282:36077-36089. Pubmed: 17928292